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Full-Text Articles in Physical Sciences and Mathematics
E-Hooks Provide Guidance And A Soft Landing For The Microtubule Binding Domain Of Dynein, Nayere Tajielyato, Lin Li, Yunhui Peng, Joshua Alper, Emil Alexov
E-Hooks Provide Guidance And A Soft Landing For The Microtubule Binding Domain Of Dynein, Nayere Tajielyato, Lin Li, Yunhui Peng, Joshua Alper, Emil Alexov
Publications
Macromolecular binding is a complex process that involves sensing and approaching the binding partner, adopting the proper orientation, and performing the physical binding. We computationally investigated the role of E-hooks, which are intrinsically disordered regions (IDRs) at the C-terminus of tubulin, on dynein microtubule binding domain (MTBD) binding to the microtubule as a function of the distance between the MTBD and its binding site on the microtubule. Our results demonstrated that the contacts between E-hooks and the MTBD are dynamical; multiple negatively charted patches of amino acids on the E-hooks grab and release the same positively charged patches on the …
Identifying Weak Interdomain Interactions That Stabilize The Supertertiary Structure Of The N-Terminal Tandem Pdz Domains Of Psd-95, Inna S. Yanez Orozco, Frank A. Mindlin, Junyan Ma, Bo Wang, Brie Levesque, Matheu Spencer, Soheila Rezaei Adariani, George Hamilton, Feng Ding, Mark E. Bowen, Hugo Sanabria
Identifying Weak Interdomain Interactions That Stabilize The Supertertiary Structure Of The N-Terminal Tandem Pdz Domains Of Psd-95, Inna S. Yanez Orozco, Frank A. Mindlin, Junyan Ma, Bo Wang, Brie Levesque, Matheu Spencer, Soheila Rezaei Adariani, George Hamilton, Feng Ding, Mark E. Bowen, Hugo Sanabria
Publications
Previous studies of the N-terminal PDZ tandem from PSD-95 produced divergent models and failed to identify interdomain contacts stabilizing the structure. We used ensemble and single-molecule FRET along with replica-exchange molecular dynamics to fully characterize the energy landscape. Simulations and experiments identified two conformations: an open-like conformation with a small contact interface stabilized by salt bridges, and a closed-like conformation with a larger contact interface stabilized by surface-exposed hydrophobic residues. Both interfaces were confirmed experimentally. Proximity of interdomain contacts to the binding pockets may explain the observed coupling between conformation and binding. The low-energy barrier between conformations allows submillisecond dynamics, …
A Versatile Carbon Nanotube-Based Scalable Approach For Improving Interfaces In Li-Ion Battery Electrodes, Lakshman K. Ventrapragada, Jingyi Zhu, Stephen E. Creager, Apparao M. Rao, Ramakrishna Podila
A Versatile Carbon Nanotube-Based Scalable Approach For Improving Interfaces In Li-Ion Battery Electrodes, Lakshman K. Ventrapragada, Jingyi Zhu, Stephen E. Creager, Apparao M. Rao, Ramakrishna Podila
Publications
Resistive interfaces within the electrodes limit the energy and power densities of a battery, for example, a Li-ion battery (LIB). Typically, active materials are mixed with conductive additives in organic solvents to form a slurry, which is then coated on current collectors (e.g., bare or carbon-coated Al foils) to reduce the inherent resistance of the active material. Although many approaches using nanomaterials to either replace Al foils or improve conductivity within the active materials have been previously demonstrated, the resistance at the current collector active material interface (CCAMI), a key factor for enhancing the energy and power densities, remains unaddressed. …
Metallic Mxenes: A New Family Of Materials For Flexible Triboelectric Nanogenerators, Yongchang Dong, Sai Sunil Kumar Mallineni, Kathleen Maleski, Herbert Behlow, Vadym N. Mochalin, Apparao M. Rao, Yury Gogosti, Ramakrishna Podila
Metallic Mxenes: A New Family Of Materials For Flexible Triboelectric Nanogenerators, Yongchang Dong, Sai Sunil Kumar Mallineni, Kathleen Maleski, Herbert Behlow, Vadym N. Mochalin, Apparao M. Rao, Yury Gogosti, Ramakrishna Podila
Publications
Wearable and flexible electronics warrant the development of self-powered devices to circumvent the limitations imposed by traditional energy storage devices. Triboelectric nanogenerators (TENGs) that convert waste mechanical energy from human motion into electric power offer a solution. Highly electronegative and conducting TENG materials that support the generation of both large potential differences and high currents are imperative for effectively harvesting electric power from human muscle movements. Here, we demonstrate that two-dimensional MXenes (e.g., titanium carbide Ti3C2Tx, where Tx stands for surface functional groups such as -O, -OH, and -F) are a family of electrically conducting materials that are triboelectrically more …
Gamma-Ray-Emitting Narrow-Line Seyfert 1 Galaxies In The Sloan Digital Sky Survey, Vaidehi S. Paliya, M. Ajello, A. Mandal, C. S. Stalin, A. Kaur, D. Hartmann
Gamma-Ray-Emitting Narrow-Line Seyfert 1 Galaxies In The Sloan Digital Sky Survey, Vaidehi S. Paliya, M. Ajello, A. Mandal, C. S. Stalin, A. Kaur, D. Hartmann
Publications
The detection of significant γ-ray emission from radio-loud narrow-line Seyfert 1 (NLSy1s) galaxies enables us to study jets in environments different than those in blazars. However, due to the small number of known γ-ray-emitting NLSy1 (γ-NLSy1) galaxies, a comprehensive study could not be performed. Here, we report the first detection of significant γ-ray emission from four active galactic nuclei (AGNs), recently classified as NLSy1 from their Sloan Digital Sky Survey (SDSS) optical spectrum. Three flat-spectrum radio quasars (FSRQs) present in the third Large Area Telescope AGN catalog (3LAC) are also found as γ-NLSy1 galaxies. …