Physical Sciences and Mathematics Commons^™

Four Period Crossover Designs, James F. Reed Iii

Journal of Modern Applied Statistical Methods

In higher-order four period crossover designs with two treatments, sixteen possible treatment sequences can result: AAAA, AAAB, AABA, AABB, ABAA, ABAB, ABBA, ABBB and their duals. Higher-order crossover designs are useful for several reasons: they allow estimation of a treatment effect even in the presence of a carry-over effect, they provide estimates of intra-subject variability and they draw inference on the carry-over effect. The real question related to a two-treatment four-period crossover design is the real world application of these designs. This article considers four designs: Design I: ABBA and its dual; Design II: ABBA, AABB and their duals, Design …