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Full-Text Articles in Physical Sciences and Mathematics
Comparing Performance Of Gene Set Test Methods Using Biologically Relevant Simulated Data, Richard M. Lambert
Comparing Performance Of Gene Set Test Methods Using Biologically Relevant Simulated Data, Richard M. Lambert
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Today we know that there are many genetically driven diseases and health conditions. These problems often manifest only when a set of genes are either active or inactive. Recent technology allows us to measure the activity level of genes in cells, which we call gene expression. It is of great interest to society to be able to statistically compare the gene expression of a large number of genes between two or more groups. For example, we may want to compare the gene expression of a group of cancer patients with a group of non-cancer patients to better understand the genetic …
The Prior Distribution In Bayesian Statistics, Kai-Tang Chen
The Prior Distribution In Bayesian Statistics, Kai-Tang Chen
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
A major problem associated with Bayesian estimation is selecting the prior distribution. The more recent literature on the selection of the prior is reviewed. Very little of a general nature on the selection of the prior is formed in the literature except for non-informative priors. This class of priors is seen to have limited usefulness. A method of selecting an informative prior is generalized in this thesis to include estimation of several parameters using a multivariate prior distribution. The concepts required for quantifying prior information is based on intuitive principles. In this way, it can be understood and controlled by …