Physical Sciences and Mathematics Commons^™

K-Mer Analysis On Developmental And Housekeeping Enhancer Peaks, Yunsi Yang, Anurag Sethi, Mark Gerstein

Yale Day of Data

The regulation of gene expression involves interaction between transcriptional enhancers and core promoters. However, the separation between developmental and housekeeping gene regulation remains unknown. Here, we present a method to detect if different core promoters exhibit specificity to certain enhancers within massively parallel assays for enhancer detection. We use k-mers of various length (3-8bp) as sequence features and compare k-mer frequencies between developmental and housekeeping enhancers. This method shows promoter specificity of enhancers in D. melanogaster.

Stratified Meta-Analysis To Examine Data Biases In Lung Cancer Studies Of Refinery Workers, Sherman Selix

Yale Day of Data

Petroleum refineries employ a variety of workers who historically experienced different potentials for asbestos exposure depending on job tasks. Associations between petroleum refinery work and lung cancer related to occupational asbestos exposure have been quantified among various locations, corporations, and time periods. To combine the data from several individual refinery studies and examine an overall effect, a systematic review and stratified meta-analysis was employed. Using set search terms among four databases, 112 potential publications were identified, of which 29 qualified for meta-analysis. Risk estimates and confidence intervals were extracted from these publications to construct four separate datasets. Inverse variance weighting …

Data Analysis Using Regression Modeling: Visual Display And Setup Of Simple And Complex Statistical Models, Emil N. Coman, Maria A. Coman, Eugen Iordache, Russell Barbour, Lisa Dierker

Yale Day of Data

We present visual modeling solutions for testing simple and more advanced statistical hypotheses in any research field. All models can be directly specified in analytical software like Mplus or R.

Data analysis in any substantive field can be easily accomplished by translating statistical tests in the intuitive language of regression-based path diagrams with observed and unobserved variables. All models we presented can be directly specified and estimated in analytical software.

Students can particularly benefit from being taught the simple regression modeling setup of the path analytical method, as it empowers them to apply the techniques to any data to test …