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Full-Text Articles in Physical Sciences and Mathematics
Associations Of Hemodynamics, Morphology, And Patient Characteristics With Aneurysm Rupture Stratified By Aneurysm Location, Felicitas J. Detmer, Bong Jae Chung, Carlos Jimenez, Farid Hamzei-Sichani, David Kallmes, Christopher Putman, Juan R. Cebral
Associations Of Hemodynamics, Morphology, And Patient Characteristics With Aneurysm Rupture Stratified By Aneurysm Location, Felicitas J. Detmer, Bong Jae Chung, Carlos Jimenez, Farid Hamzei-Sichani, David Kallmes, Christopher Putman, Juan R. Cebral
Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works
Purpose: The mechanisms of cerebral aneurysm rupture are not fully understood. We analyzed the associations of hemodynamics, morphology, and patient age and gender with aneurysm rupture stratifying by location. Methods: Using image-based models, 20 hemodynamic and 17 morphological parameters were compared in 1931 ruptured and unruptured aneurysms with univariate logistic regression. Rupture rates were compared between males and females as well as younger and older patients and bifurcation versus sidewall aneurysms for different aneurysm locations. Subsequently, associations between hemodynamics and morphology and patient as well as aneurysm characteristics were analyzed for aneurysms at five locations. Results: Compared to unruptured aneurysms, …
Cfd For Evaluation And Treatment Planning Of Aneurysms: Review Of Proposed Clinical Uses And Their Challenges, Bong Jae Chung, Juan Raul Cebral
Cfd For Evaluation And Treatment Planning Of Aneurysms: Review Of Proposed Clinical Uses And Their Challenges, Bong Jae Chung, Juan Raul Cebral
Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works
Computational fluid dynamics (CFD) has been used for several years to identify mechanical risk factors associated with aneurysmal evolution and rupture as well as to understand flow characteristics before and after surgical treatments in order to help the clinical decision making process. We used the keywords, “CFD” and “aneurysms” to search recent publications since about 2000, and categorized them into (i) studies of rupture risk factors and (ii) investigations of pre- and post-evaluations of surgical treatment with devices like coils and flow diverters (FD). This search enables us to examine the current status of CFD as a clinical tool and …