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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Color-Connected Graphs And Information-Transfer Paths, Stephen Devereaux
Color-Connected Graphs And Information-Transfer Paths, Stephen Devereaux
Dissertations
The Department of Homeland Security in the United States was created in 2003 in response to weaknesses discovered in the transfer of classied information after the September 11, 2001 terrorist attacks. While information related to national security needs to be protected, there must be procedures in place that permit access between appropriate parties. This two-fold issue can be addressed by assigning information-transfer paths between agencies which may have other agencies as intermediaries while requiring a large enough number of passwords and rewalls that is prohibitive to intruders, yet small enough to manage. Situations such as this can be represented by …
Quantifying The Structure Of Misfolded Proteins Using Graph Theory, Walter G. Witt
Quantifying The Structure Of Misfolded Proteins Using Graph Theory, Walter G. Witt
Electronic Theses and Dissertations
The structure of a protein molecule is highly correlated to its function. Some diseases such as cystic fibrosis are the result of a change in the structure of a protein so that this change interferes or inhibits its function. Often these changes in structure are caused by a misfolding of the protein molecule. To assist computational biologists, there is a database of proteins together with their misfolded versions, called decoys, that can be used to test the accuracy of protein structure prediction algorithms. In our work we use a nested graph model to quantify a selected set of proteins that …
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Theses and Dissertations
miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif …