Physical Sciences and Mathematics Commons^™

A Framework Of Multi-Dimensional And Multi-Scale Modeling With Applications, Zilong Li

Doctoral Dissertations

In this dissertation, a framework for multi-dimensional and multi-scale modeling is proposed. The essential idea is based on oriented space curves, which can be represented as a 3D slender object or 1D step parameters. SMILES and Masks provide functionalities that extend slender objects into branched and other objects. We treat the conversion between 1D, 2D, 3D, and 4D representations as data unification. A mathematical analysis of different methods applied to helices (a special type of space curves) is also provided. Computational implementation utilizes Model-ViewController design principles to integrate data unification with graphical visualizations to create a dashboard. Applications of multi-dimensional …

Adaptive Feature Engineering Modeling For Ultrasound Image Classification For Decision Support, Hatwib Mugasa

Doctoral Dissertations

Ultrasonography is considered a relatively safe option for the diagnosis of benign and malignant cancer lesions due to the low-energy sound waves used. However, the visual interpretation of the ultrasound images is time-consuming and usually has high false alerts due to speckle noise. Improved methods of collection image-based data have been proposed to reduce noise in the images; however, this has proved not to solve the problem due to the complex nature of images and the exponential growth of biomedical datasets. Secondly, the target class in real-world biomedical datasets, that is the focus of interest of a biopsy, is usually …

Spatiotemporal Subspace Feature Tracking By Mining Discriminatory Characteristics, Richard D. Appiah

Doctoral Dissertations

Recent advancements in data collection technologies have made it possible to collect heterogeneous data at complex levels of abstraction, and at an alarming pace and volume. Data mining, and most recently data science seek to discover hidden patterns and insights from these data by employing a variety of knowledge discovery techniques. At the core of these techniques is the selection and use of features, variables or properties upon which the data were acquired to facilitate effective data modeling. Selecting relevant features in data modeling is critical to ensure an overall model accuracy and optimal predictive performance of future effects. The …

Generalized Partial Directed Coherence And Centrality Measures In Brain Networks For Epileptogenic Focus Localization, Joshua Aaron Adkinson

Doctoral Dissertations

Accurate epileptogenic focus localization is required prior to surgical resection of brain tissue for treatment of patients with intractable temporal lobe epilepsy, a clinical need that is partially fulfilled to date through a subjective, and at times inconclusive, evaluation of the recorded electroencephalogram (EEG). Using brain connectivity analysis, patterns of causal interactions between brain regions were derived from multichannel EEG of 127 seizures in nine patients with focal, temporal lobe epilepsy (TLE). The statistically significant directed interactions in the reconstructed brain networks were estimated from three second intracranial multi-electrode EEG segments using the Generalized Partial Directed Coherence (GPDC) and validated …

Thermal Analysis In A Triple-Layered Skin Structure With Embedded Vasculature, Tumor, And Gold Nanoshells, Casey O. Orndorff

Doctoral Dissertations

In hyperthermia skin cancer treatment, the objective is to control laser heating of the tumor (target temperatures of 42-46 °C) so that the temperatures of the normal tissue surrounding the tumor remains low enough not to damage the normal tissue. However, obtaining accurate temperature distributions in living tissue related to hyperthermia skin cancer treatment without using an intruding sensor is a challenge. The objective of this dissertation research is to develop a mathematical model that can accurately predict the temperature distribution in the tumor region and surrounding normal tissue induced by laser irradiation. The model is based on a modified …

Computational Micro-Flow With Spectral Element Method And High Reynolds Number Flow With Discontinuous Galerkin Finite Element Method, Haibo Zhang

Doctoral Dissertations

In this dissertation, two numerical methods with high order accuracy, Spectral Element Method (SEM) and Discontinuous Galerkin Finite Element Method (DG-FEM), are chosen to solve problems in Computational Fluid Dynamics (CFD). The merits of these two methods will be discussed and utilized in different kinds of CFD problems. The simulations of the micro-flow systems with complex geometries and physical applications will be presented by SEM. Moreover, the numerical solutions for the Hyperbolic Flow will be obtained by DG-FEM. By solving problems with these two methods, the differences between them will be discussed as well.

Compressible Navier-Stokes equations with Electro-osmosis body …

Sensitivity Of Mixed Models To Computational Algorithms Of Time Series Data, Gunaime Nevine

Doctoral Dissertations

Statistical analysis is influenced by implementation of the algorithms used to execute the computations associated with various statistical techniques. Over many years; very important criteria for model comparison has been studied and examined, and two algorithms on a single dataset have been performed numerous times. The goal of this research is not comparing two or more models on one dataset, but comparing models with numerical algorithms that have been used to solve them on the same dataset.

In this research, different models have been broadly applied in modeling and their contrasting which are affected by the numerical algorithms in different …

Analysis Of A Mathematical Model For The Heave Motion Of A Micro Aerial Vehicle With Flexible Wings Having Non-Local Damping Effects, Jonathan B. Walters

Doctoral Dissertations

In this work we analyze a one dimensional model for a flexible wing micro aerial vehicle which can undergo heaving motion. The vehicle is modeled with a non-local type of internal damping known as spatial hysteresis as well as viscous external damping. We present a rigorous theoretical analysis of the model proving that the linearly approximated system is well-posed and the first order feedback system operators generate exponentially stable C0–semigroups.

Furthermore, we present numerical simulations of control designs used on the linearly approximated model to control the associated nonlinear model in two different strategies. The first strategy used to …

Numerical Solutions For Problems With Complex Physics In Complex Geometry, Yifan Wang

Doctoral Dissertations

In this dissertation, two high order accurate numerical methods, Spectral Element Method (SEM) and Discontinuous Galerkin method (DG), are discussed and investigated. The advantages of both methods and their applicable areas are studied. Particular problems in complex geometry with complex physics are investigated and their high order accurate numerical solutions obtained by using either SEM or DG are presented. Furthermore, the Smoothed Particle Hydrodynamics (SPH) (a mesh-free weighted interpolation method) is implemented on graphics processing unit (GPU). Some numerical simulations of the complex flow with a free surface are presented and discussed to show the advantages of SPH method in …

Modeling And Control Of Nanoparticle Bloodstream Concentration For Cancer Therapies, Scarlett S. Bracey

Doctoral Dissertations

Currently, the most commonly used treatments for cancerous tumors (chemotherapy, radiation, etc.) have almost no method of monitoring the administration of the treatment for adverse effects in real time. Without any real time feedback or control, treatment becomes a "guess and check" method with no way of predicting the effects of the drugs based on the actual bioavailability to the patient's body. One particular drug may be effective for one patient, yet provide no benefit to another. Doctors and scientists do not routinely attempt to quantifiably explain this discrepancy. In this work, mathematical modeling and analysis techniques are joined together …

A Mathematical Model And Numerical Method For Thermoelectric Dna Sequencing, Liwei Shi

Doctoral Dissertations

DNA sequencing is the process of determining the precise order of nucleotide bases, adenine, guanine, cytosine, and thymine within a DNA molecule. It includes any method or technology that is used to determine the order of the four bases in a strand of DNA. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Thermoelectric DNA sequencing is a novel method to sequence DNA by measuring the heat that is released when DNA polymerase inserts a deoxyribonucleoside triphosphate into a growing DNA strand. The thermoelectric device for this project is composed of four parts: …

Generalized Finite-Difference Time-Domain Schemes For Solving Nonlinear Schrödinger Equations, Frederick Ira Moxley Iii

Doctoral Dissertations

The nonlinear Schrödinger equation (NLSE) is one of the most widely applicable equations in physical science, and characterizes nonlinear dispersive waves, optics, water waves, and the dynamics of molecules. The NLSE satisfies many mathematical conservation laws. Moreover, due to the nonlinearity, the NLSE often requires a numerical solution, which also satisfies the conservation laws. Some of the more popular numerical methods for solving the NLSE include the finite difference, finite element, and spectral methods such as the pseudospectral, split-step with Fourier transform, and integrating factor coupled with a Fourier transform. With regard to the finite difference and finite element methods, …

Exploration Of Aqueous Interfaces And Their Effect On Ion Behavior, Oneka T. Cummings

Doctoral Dissertations

An in-depth understanding of a wide range of physical, chemical, atmospheric and biological processes can only be achieved after the structure and dynamics of interfaces and the interfacial behavior of aqueous species, such as ions, are thoroughly studied and understood. This dissertation describes computational studies conducted to gain a more comprehensive understanding of such interfaces and the behavior of ions in the bulk and interfacial regions of the (1) air/water interface, and (2) alkane/water interfaces.

At the air/water interface the effect of counterion (sodium cations) charge and the influence of ion pairing on anion (chloride) propensity for the air/water interface …

New Microarray Image Segmentation Using Segmentation Based Contours Method, Yuan Cheng

Doctoral Dissertations

The goal of the research developed in this dissertation is to develop a more accurate segmentation method for Affymetrix microarray images. The Affymetrix microarray biotechnologies have become increasingly important in the biomedical research field. Affymetrix microarray images are widely used in disease diagnostics and disease control. They are capable of monitoring the expression levels of thousands of genes simultaneously. Hence, scientists can get a deep understanding on genomic regulation, interaction and expression by using such tools.

We also introduce a novel Affymetrix microarray image simulation model and how the Affymetrix microarray image is simulated by using this model. This simulation …

The Search For An Optimal Means Of Determining The Minmax Control Parameter Using Sensitivity Analysis, John Teye Brown

Doctoral Dissertations

The use of computational methods for design and simulation of control systems allows for a cost-effective trial and error approach. In this work, we are concerned with the robust, real-time control of physical systems whose state space is infinite-dimensional. Such systems are known as Distributed Parameter Systems (DPS). A body whose state is heterogeneous is a distributed parameter. In particular, this work focuses on DPS systems that are governed by linear Partial Differential Equations, such as the heat equation. We specifically focus on the MinMax controller, which is regarded as being a very robust controller. The mathematical formulation of the …

Mathematical Modeling Of Pipeline Features For Robotic Inspection, Yang Gao

Doctoral Dissertations

Underground pipeline systems play an indispensable role in transporting liquids in both developed and developing countries. The associated social and economic cost to repair a pipe upon abrupt failure is often unacceptable. Regular inspection is a preventative action that aims to monitor pipe conditions, catch abnormalities and reduce the chance of undesirable surprises. Robots with CCTV video cameras have been used for decades to inspect pipelines, yielding only qualitative information. It is becoming necessary and preferable for municipalities, project managers and engineers to also quantify the 3-D geometry of underground pipe networks. Existing robots equipped specialized hardware and software algorithms …

Near-Optimal Scheduling And Decision-Making Models For Reactive And Proactive Fault Tolerance Mechanisms, Nichamon Naksinehaboon

Doctoral Dissertations

As High Performance Computing (HPC) systems increase in size to fulfill computational power demand, the chance of failure occurrences dramatically increases, resulting in potentially large amounts of lost computing time. Fault Tolerance (FT) mechanisms aim to mitigate the impact of failure occurrences to the running applications. However, the overhead of FT mechanisms increases proportionally to the HPC systems' size. Therefore, challenges arise in handling the expensive overhead of FT mechanisms while minimizing the large amount of lost computing time due to failure occurrences.

In this dissertation, a near-optimal scheduling model is built to determine when to invoke a hybrid checkpoint …

Modeling And Control For Heave Dynamics Of A Flexible Wing Micro Aerial Vehicle Distributed Parameter System, Lisa M. Kuhn

Doctoral Dissertations

In recent years, much research has been motivated by the idea of biologically-inspired flight. It is a conjecture of the United States Air Force that incorporating characteristics of biological flight into air vehicles will significantly improve the maneuverability and performance of modern aircraft. Although there are studies which involve the aerodynamics, structural dynamics, modeling, and control of flexible wing micro aerial vehicles (MAVs), issues of control and vehicular modeling as a whole are largely unexplored. Modeling with such dynamics lends itself to systems of partial differential equations (PDEs) with nonlinearities, and limited control theory is available for such systems.

In …

A Numerical Method For Studying Thermal Deformation In 3d Double-Layered Thin Films With Imperfect Interfacial Thermal Contact Exposed To Ultrashort-Pulsed Lasers, Runzhou Liu

Doctoral Dissertations

Micro heat transfer induced by Ultrashort-pulsed lasers is an important research topic in mechanical engineering and material science. In order to apply ultrashort-pulsed lasers successfully, studying the thermal deformation in double-layered thin films with imperfect thermal interfacial contact induced by ultrashort-pulsed lasers is important for preventing thermal damage. For the ultrashort-pulsed laser, the thermal damage is different from that caused by the long-pulsed lasers, and ultrafast cracks occur after heating.

This dissertation presents a new finite difference method for investigating the thermal deformation in a 3D gold-chromium thin film with imperfect interfacial thermal contact exposed to ultrashort-pulsed lasers. The method …

Improving The Accuracy Of The Generalized Fdtd-Q Scheme For Solving The Linear Time-Dependent Schrödinger Equation, James John Elliot Iii

Doctoral Dissertations

This dissertation improves the accuracy of the Generalized Finite Difference Time Domain (FDTD) scheme by determining a differential operator that is capable of achieving reasonable accuracy when used to obtain even-order derivatives up to order fourteen. The Generalized FDTD scheme is an explicit, scheme used to solve the time-dependent Schrödinger equation, and being an explicit scheme, it must utilize a carefully devised ratio of the temporal step to the spatial step to maintain numerical stability. This ratio is called the mesh ratio, and the Generalized FDTD scheme allows this ratio to be significantly relaxed. As the mesh ratio increases, the …

Shape Reconstruction And Classification Using The Response Matrix, Wei Wang

Doctoral Dissertations

This dissertation presents a novel method for the inverse scattering problem for extended target. The acoustic or electromagnetic wave is scattered by the target and received by all the transducers around the target. The scattered field on all the transducers forms the response matrix which contains the information of the geometry of the target. The objective of the inverse scattering problem is to reconstruct the shape of the scatter using the Response Matrix.

There are two types of numerical methods for solving the inverse problem: the direct imaging method and the iterative method. Two direct imaging methods, MUSIC method and …

A Numerical Method For Solving The Elliptic And Elasticity Interface Problems, Liqun Wang

Doctoral Dissertations

Interface problems arise when dealing with physical problems composed of different materials or of the same material at different states. Because of the irregularity along interfaces, many common numerical methods do not work, or work poorly, for interface problems. Matrix-coefficient elliptic and elasticity equations with oscillatory solutions and sharp-edged interfaces are especially complicated and challenging for most existing methods. An accurate and efficient method is desired.

In 1999, the boundary condition capturing method was proposed to deal with Poisson equations with interfaces whose variable coefficients and solutions may be discontinuous. In 2003, a weak formulation was derived. Built on previous …

Results In Lattices, Ortholattices, And Graphs, Jianning Su

Doctoral Dissertations

This dissertation contains two parts: lattice theory and graph theory. In the lattice theory part, we have two main subjects. First, the class of all distributive lattices is one of the most familiar classes of lattices. We introduce "π-versions" of five familiar equivalent conditions for distributivity by applying the various conditions to 3-element antichains only. We prove that they are inequivalent concepts, and characterize them via exclusion systems. A lattice L satisfies D0π, if a ✶ (b ✶ c) ≤ (a ✶ b) ✶ c for all 3-element antichains { a, b, c}. We consider …

Vascular Countercurrent Network For 3d Triple-Layered Skin Structure With Radiation Heating, Xiaoqi Zeng

Doctoral Dissertations

Heat transfer in living tissue has become more and more attention for researchers, because high thermal radiation produced by intense fire, such as wild fires, chemical fires, accidents, warfare, terrorism, etc, is often encountered in human's daily life. Living tissue is a heterogeneous organ consisting of cellular tissue and blood vessels, and heat transfer in cellular tissue and blood vessel is quite different, because the blood vessels provide channels for fast heat transfer. The metabolic heat generation, heat conduction and blood perfusion in soft tissue, convection and perfusion of the arterial-venous blood through the capillary, and interaction with the environment …

Accurate And Stable Numerical Methods For Solving Micro Heat Transfer Models In An N-Carrier System In Spherical Coordinates, Di Zhao

Doctoral Dissertations

Energy exchange between electrons and phonons in metal provides the best example in describing non-equilibrium heating during the ultrafast transient. In times comparable to the thermalization and relaxation time of electrons and phonons, which are in the range of a few to several tens of picoseconds, heat continuously flows from hot electrons to cold phonons through mutual collisions. Consequently, electron temperature continuously decreases whereas phonon temperature continuously increases until thermal equilibrium is reached. Tien developed the well-known parabolic two-step model for describing the non-equilibrium heating in the electron-phonon system in 1992, and Tzou developed the parabolic model for the non-equilibrium …

A Hyperbolic Two -Step Model Based Finite Difference Method For Studying Thermal Deformation In A Micro Thin Film Heated By Ultrashort -Pulsed Lasers, Tianchan Niu

Doctoral Dissertations

Heat transport through micro thin films plays a very important role in microtechnology applications. Many microelectronic devices have metal thin films as their key components. Microscale heat transfer is also important for the thermal processing of materials, including laser micromachining, laser patterning, laser synthesis and laser surface hardening. Hence, studying the thermal behavior of thin films is essential for predicting the performance of a microelectronic device or for obtaining the desired microstructure. Recently, it has become very popular to use ultrashort-pulsed lasers in thermal processing, which lasers have pulse durations of the order of subpicoseconds to femtoseconds, and these kinds …

A Numerical Method For Obtaining An Optimal Temperature Distribution In A Three-Dimensional Triple-Layered Skin Structure Embedded With Multi-Level Blood Vessels, Xingui Tang

Doctoral Dissertations

The research related to hyperthermia has stimulated a lot of interest in recent years because of its application in cancer treatment. When heating the tumor tissue, the crucial problem is keeping the temperature of the surrounding normal tissue below a certain threshold in order to avoid the damage to the normal tissue. Hence, it is important to obtain the temperature field of the entire region during the treatment. The objective of this dissertation is to develop a numerical method for obtaining an optimal temperature distribution in a 3D triple-layered skin structure embedded with multi-level blood vessels where the surface of …

Pattern Recognition For Electric Power System Protection, Yong Sheng

Doctoral Dissertations

The objective of this research is to demonstrate pattern recognition tools such as decision trees (DTs) and neural networks that will improve and automate the design of relay protection functions in electric power systems. Protection functions that will benefit from the research include relay algorithms for high voltage transformer protection (TP) and for high impedance fault (HIF) detection. A methodology, which uses DTs and wavelet analysis to distinguish transformer internal faults from other conditions that are easily mistaken for internal faults, has been developed. Also, a DT based solution is proposed to discriminate HIFs from normal operations that may confuse …