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Physical Sciences and Mathematics Commons

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Applied Mathematics

William & Mary

Undergraduate Honors Theses

2024

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Full-Text Articles in Physical Sciences and Mathematics

Identifying Transitions In Plasma With Topological Data Analysis Of Noisy Turbulence, Julius Kiewel May 2024

Identifying Transitions In Plasma With Topological Data Analysis Of Noisy Turbulence, Julius Kiewel

Undergraduate Honors Theses

Cross-field transport and heat loss in a magnetically confined plasma is determined by turbulence driven by perpendicular (to the magnetic field) pressure gradients. The heat losses from turbulence can make it difficult to maintain the energy density required to reach and maintain the conditions necessary for fusion. Self-organization of turbulence into intermediate scale so-called zonal flows can reduce the radial heat losses, however identifying when the transition occurs and any precursors to the transition is still a challenge. Topological Data Analysis (TDA) is a mathematical method which is used to extract topological features from point cloud and digital data to …


Mathematical Modeling And Examination Into Existing And Emerging Parkinson’S Disease Treatments: Levodopa And Ketamine, Gabrielle Riddlemoser May 2024

Mathematical Modeling And Examination Into Existing And Emerging Parkinson’S Disease Treatments: Levodopa And Ketamine, Gabrielle Riddlemoser

Undergraduate Honors Theses

Parkinson’s disease (PD) is the second most common neurodegenerative disease across the world, affecting over 6 million people worldwide. This disorder is characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta (SNpc) due to the aggregation of α-synuclein within the brain. Patients with PD develop motor symptoms such as tremors, bradykinesia, and postural instability, as well as a host of non-motor symptoms such as behavioral changes, sleep difficulties, and fatigue. The reduction of dopamine within the brain is the primary cause of these symptoms. The main form of treatment for PD is levodopa, a precursor …