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Physical Sciences and Mathematics Commons

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Applied Mathematics

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William & Mary

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Full-Text Articles in Physical Sciences and Mathematics

Introducing R, Lawrence Leemis Jan 2022

Introducing R, Lawrence Leemis

Arts & Sciences Book Chapters

R is an open source programming language and interactive programming environment that has become the software tool of choice in data analytics. Learning Base R provides an introduction to the language for those with and without prior programming experience. It introduces the key topics that you will need to begin analyzing data and programming in R. The focus here is on the R language rather than a particular application. Within the text, there are 200 exercises to assess your R skills.


Regenerative Ionic Currents And Bistability, Gregory D. Conradi Smith Apr 2019

Regenerative Ionic Currents And Bistability, Gregory D. Conradi Smith

Arts & Sciences Book Chapters

What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem …


Lower Confidence Bounds For System Reliability From Binary Failure Data Using Bootstrapping, Lawrence Leemis Jan 2009

Lower Confidence Bounds For System Reliability From Binary Failure Data Using Bootstrapping, Lawrence Leemis

Arts & Sciences Book Chapters

We consider the problem of determining a (1 – A) 100% lower confidence bound on the system reliability for a coherent system of k components using the failure data (yi, ni), where yi is the number of components of type i that pass the test and ni is the number of components of type i on test, i1, 2, …, k. We assume throughout that the components fail independently, e.g. no common-cause failures. The outline of the article is as follows. We begin with the case of a single (k1) component system where n components are placed on a test …


A Population Density Model Of The Driven Lgn/Pgn, Marco A. Huertas, Gregory D. Smith Jan 2009

A Population Density Model Of The Driven Lgn/Pgn, Marco A. Huertas, Gregory D. Smith

Arts & Sciences Book Chapters

The interaction of two populations of integrate-and-fire-or-burst neurons representing thalamocortical cells from the dorsal lateral geniculate nucleus (dLGN) and thalamic reticular cells from the perigeniculate nucleus (PGN) is studied using a population density approach. A two-dimensional probability density function that evolves according to a time-dependent advection-reaction equation gives the distribution of cells in each population over the membrane potential and de-inactivation level of a low-threshold calcium current. In the absence of retinal drive, the population density network model exhibits rhythmic bursting. In the presence of constant retinal input, the aroused LGN/PGN population density model displays a wide range of responses …