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Full-Text Articles in Physical Sciences and Mathematics
Direct Immunoassays And Their Performance: Theoretical Modelling Of The Effects Of Antibody Orientation And Associated Kinetics, Dana Mackey, Eilis Kelly, Robert Nooney, Richard O'Kennedy
Direct Immunoassays And Their Performance: Theoretical Modelling Of The Effects Of Antibody Orientation And Associated Kinetics, Dana Mackey, Eilis Kelly, Robert Nooney, Richard O'Kennedy
Articles
The orientation and activity of antibodies immobilized on solid surfaces are of direct relevance to many immunosensing applications. We therefore investigate a mathematical model which estimates the fraction of antibodies which are available for reaction in a randomly adsorbed sample. Numerical simulations are presented which highlight the separate effects of antibody orientation, accessibility and loss of binding ability on the amount of captured antigen. The assay response can then be expressed as a function of total antibody density and used for optimizing the surface coverage strategy under various conditions.
Fluid-Dynamic Models Of Geophysical Waves, Alan Compelli
Fluid-Dynamic Models Of Geophysical Waves, Alan Compelli
Doctoral
Geophysical waves are waves that are found naturally in the Earth's atmosphere and oceans. Internal waves, that is waves that act as an interface between uids of dierent density, are examples of geophysical waves. A uid system with a at bottom, at surface and internal wave is initially considered. The system has a depth-dependent current which mimics a typical ocean set-up and, as it is based on the surface of the rotating Earth, incorporates Coriolis forces. Using well established uid dynamic techniques, the total energy is calculated and used to determine the dynamics of the system using a procedure called …