Physical Sciences and Mathematics Commons^™

Modelling Random Antibody Adsorption And Immunoassay Activity, Dana Mackey, Eilis Kelly, Robert Nooney

Articles

One of the primary considerations in immunoassay design is optimizing the concentration of capture antibody in order to achieve maximal antigen binding and, subsequently, improved sensitivity and limit of detection. Many immunoassay technologies involve immobilization of the antibody to solid surfaces. Antibodies are large molecules in which the position and accessibility of the antigen-binding site depend on their orientation and packing density. In this paper we propose a simple mathematical model, based on the theory known as random sequential adsorption (RSA), in order to calculate how the concentration of correctly oriented antibodies (active site exposed for subsequent reactions) evolves during …

Theoretical Modeling Of The Effect Of Polymer Chain Immobilization Rates On Holographic Recording In Photopolymers, Dana Mackey, Paul O'Reilly, Izabela Naydenova

Articles

This paper introduces an improved mathematical model for holographic grating formation in an acrylamide-based photopolymer, which consists of partial differential equations derived from physical laws. The model is based on the two-way diffusion theory of \cite{izabela}, which assumes short polymer chains are free to diffuse, and generalizes a similar model presented in \cite{josab} by introducing an immobilization rate governed by chain growth and cross-linking. Numerical simulations were carried out in order to investigate the behaviour of the photopolymer system for short and long exposures, with particular emphasis on the effect of recording parameters (such as illumination frequency and intensity), as …

Models Of Internal Waves In The Presence Of Currents, Alan Compelli, Rossen Ivanov

Conference papers

A fluid system consisting of two domains is examined. The system is considered as being bounded at the bottom and top by a flatbed and wave-free surface respectively. An internal wave propagating in one direction, driven by gravity, acts as a free common interface between the fluids. Various current profiles are considered. The Hamiltonian of the system is determined and expressed in terms of canonical wave-related variables. Limiting behaviour is examined and compared to that of other known models. The linearised equations as well as long-wave approximations are formulated. The presented models provide potential applications to modelling of internal geophysical …

Factorized Runge-Kutta-Chebyshev Methods, Stephen O'Sullivan

Conference papers

The second-order extended stability Factorized Runge-Kutta-Chebyshev (FRKC2) class of explicit schemes for the integration of large systems of PDEs with diffusive terms is presented. FRKC2 schemes are straightforward to implement through ordered sequences of forward Euler steps with complex stepsizes, and easily parallelised for large scale problems on distributed architectures.

Preserving 7 digits for accuracy at 16 digit precision, the schemes are theoretically capable of maintaining internal stability at acceleration factors in excess of 6000 with respect to standard explicit Runge-Kutta methods. The stability domains have approximately the same extents as those of RKC schemes, and are a third longer …

A Competitive Random Sequential Adsorption Model For Immunoassay Activity, Dana Mackey, Eilis Kelly, Robert Nooney

Conference papers

Immunoassays rely on highly specific reactions between antibodies and antigens and are used in biomedical diagnostics applications to detect biomarkers for a variety of diseases. Antibody immobilization to solid interfaces through random adsorption is a widely used technique but has the disadvantage of severely reducing the antigen binding activity and, consequently, the assay performance. This paper proposes a simple mathematical framework, based on the theory known as competitive random sequential adsorption (CRSA), for describing how the activity of immobilized antibodies depends on their orientation and packing density and generalizes a previous model by introducing the antibody aspect ratio as an …

The Neural Dynamics Of Somatosensory Processing And Adaptation Across Childhood: A High-Density Electrical Mapping Study, Neha Uppal, John J. Foxe, John Butler, Frantzy Acluche, Sophie Molholm

Articles

Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. Based on the idea that neurodevelopmental changes in somatosensory processing and/or changes in sensory adaptation might underlie developmental differences in somatosensory reactivity, high-density electroencephalography was used to examine how the nervous system responds and adapts to repeated vibrotactile stimulation over childhood. Participants aged 6–18 yr old were presented with 50-ms vibrotactile stimuli to the right wrist over the median nerve at 5 blocked interstimulus intervals (ranging …

On The N-Wave Equations With Pt-Symmetry, Vladimir Gerdjikov, Georgi Grahovski, Rossen Ivanov

Articles

We study extensions of N-wave systems with PT-symmetry. The types of (nonlocal) reductions leading to integrable equations invariant with respect to P- (spatial reflection) and T- (time reversal) symmetries is described. The corresponding constraints on the fundamental analytic solutions and the scattering data are derived. Based on examples of 3-wave (related to the algebra sl(3,C)) and 4-wave (related to the algebra so(5,C)) systems, the properties of different types of 1- and 2-soliton solutions are discussed. It is shown that the PT symmetric 3-wave equations may have regular multi-soliton solutions for some specific choices of their parameters.

The Dynamics Of Flat Surface Internal Geophysical Waves With Currents, Alan Compelli, Rossen Ivanov

Articles

A two-dimensional water wave system is examined consisting of two discrete incompressible fluid domains separated by a free common interface. In a geophysical context this is a model of an internal wave, formed at a pycnocline or thermocline in the ocean. The system is considered as being bounded at the bottom and top by a flatbed and wave-free surface respectively. A current profile with depth-dependent currents in each domain is considered. The Hamiltonian of the system is determined and expressed in terms of canonical wave-related variables. Limiting behavior is examined and compared to that of other known models. The linearised …

Hamiltonian Formulation For Wave-Current Interactions In Stratified Rotational Flows, Adrian Constantin, Rossen Ivanov, Calin-Iulian Martin

Articles

We show that the Hamiltonian framework permits an elegant formulation of the nonlinear governing equations for the coupling between internal and surface waves in stratified water flows with piecewise constant vorticity.