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Full-Text Articles in Physical Sciences and Mathematics
Monomials And Basin Cylinders For Network Dynamics, Daniel Austin, Ian H. Dinwoodie
Monomials And Basin Cylinders For Network Dynamics, Daniel Austin, Ian H. Dinwoodie
Mathematics and Statistics Faculty Publications and Presentations
We describe methods to identify cylinder sets inside a basin of attraction for Boolean dynamics of biological networks. Such sets are used for designing regulatory interventions that make the system evolve towards a chosen attractor, for example initiating apoptosis in a cancer cell. We describe two algebraic methods for identifying cylinders inside a basin of attraction, one based on the Groebner fan that finds monomials that define cylinders and the other on primary decomposition. Both methods are applied to current examples of gene networks.