Physical Sciences and Mathematics Commons^™

A Physiologically-Based Pharmacokinetic Model For Vancomycin, Rebekah White

Undergraduate Honors Theses

Vancomycin is an antibiotic used for the treatment of systemic infections. It is given

intravenously usually every twelve or twenty-four hours. This particular drug has a

medium level of boundedness, with approximately fty percent of the drug being free

and thus physiologically eective. A physiologically-based pharmacokinetic (PBPK)

model was used to better understand the absorption, distribution, and elimination of

the drug. Using optimal parameters, the model could be used in the future to test

how various factors, such as BMI or excretion levels, might aect the concentration

of the antibiotic.

Modeling Enrollment At A Regional University Using A Discrete-Time Markov Chain, Zachary T. Helbert

Undergraduate Honors Theses

A discrete time Markov Chain is used to model enrollment at a regional university. A preliminary analysis is conducted on the data set in order to determine the classes for the Markov chain model. The semester, yearly, and long term results of the model are examined thoroughly. A sensitivity analysis of the probability matrix entries is then conducted to determine the overall greatest influence on graduation rates.