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Component Trees For The Exploration Of Macromolecular Structures In Biology, Lucas Oliveira Oct 2014

Component Trees For The Exploration Of Macromolecular Structures In Biology, Lucas Oliveira

Dissertations, Theses, and Capstone Projects

Understanding the three-dimensional structure of a macromolecular complex is essential for understanding its function. A component tree is a topological and geometric image descriptor that captures information regarding the structure of an image based on the connected components determined by different grayness thresholds. This dissertation presents a novel interactive framework for visual exploration of component trees of the density maps of macromolecular complexes, with the purpose of improved understanding of their structure. The interactive exploration of component trees together with a robust simplification methodology provide new insights in the study of macromolecular structures. An underlying mathematical theory is introduced and …


Generalized Least-Squares Regressions Iv: Theory And Classification Using Generalized Means, Nataniel Greene Sep 2014

Generalized Least-Squares Regressions Iv: Theory And Classification Using Generalized Means, Nataniel Greene

Publications and Research

The theory of generalized least-squares is reformulated here using the notion of generalized means. The generalized least-squares problem seeks a line which minimizes the average generalized mean of the square deviations in x and y. The notion of a generalized mean is equivalent to the generating function concept of the previous papers but allows for a more robust understanding and has an already existing literature. Generalized means are applied to the task of constructing more examples, simplifying the theory, and further classifying generalized least-squares regressions.


Generalized Least-Squares Regressions Iii: Further Theory And Classification, Nataniel Greene Jan 2014

Generalized Least-Squares Regressions Iii: Further Theory And Classification, Nataniel Greene

Publications and Research

This paper continues the work of this series with two results. The first is an exponential equivalence theorem which states that every generalized least-squares regression line can be generated by an equivalent exponential regression. It follows that every generalized least-squares line has an effective normalized exponential parameter between 0 and 1 which classifies the line on the spectrum between ordinary least-squares and the extremal line for a given set of data. The second result is the presentation of fundamental formulas for the generalized least-squares slope and y-intercept.