Physical Sciences and Mathematics Commons^™

Microcapsule Biosensors Based On Competitive Binding And Fluorescence Resonance Energy Transfer Assays, Swetha Chinnayelka

Doctoral Dissertations

Fluorescent sensing systems offer the potential for minimally invasive monitoring with implantable devices, but they require carrier technologies that provide suitable immobilization, accessibility, and biocompatibility while maintaining adequate response characteristics. Towards the development of this goal, a general design of a biosensor with the capability of detecting different metabolites was investigated. The approach is based on the encapsulation of a competitive binding assay in microcapsules and monitoring the changes in fluorescence resonance energy transfer (FRET) in the presence of analyte. To experimentally demonstrate this type of sensing system, glucose was chosen as the model target analyte. The design, fabrication, and …

Elucidation Of The Mass Spectral Fragmentation Pathways Of Cyclic Hepatopeptides Microcystins, Paloma Muniz Ortea

Theses

The most frequently found cyanobacterial toxins in blooms from fresh and brackish waters are the cyclic peptide microcystins (MCs) and nodularin family. These toxins cause fatal poisonings of agricultural livestock, wild animals, birds and fish on a worldwide basis. The involvement of these toxins in human health problems has also been inferred in several countries and their presence in drinking water sources is of interest to the drinking water industry.

One of the biggest problems in the analysis of MCs is the lack of commercially available standards to be used for the identification and characterisation of these cyanobacterial toxins. One …

Exploring Marine Biotoxins Using Analytical Techniques Based On Mass Spectrometry, Mónica Fernández Amandi

Theses

The impact of phycotoxins on human and animal health is of important concern for worldwide authorities and the scientific community. Domoic acid (DA) is a neurotoxin produced by phytoplankton {Pseudonitzchia spp.). It enters the food chain through the consumption of shellfish that feed on toxic diatoms. DA has been responsible for several outbreaks affecting humans and animals all around the world. Yessotoxin (YTX) is produced by dinoflagellate species {Protoceratiuni reticulatum) which are globally distributed. Its toxicity is low when ingested orally. However, the co-extraction of YTX with diarrhetic shellfish poisoning (DSP) toxins, derives false positives when the mouse bioassay is …

Characterization Of Ionic, Dipolar And Molecular Mobility In Polymer Systems, Zhenrong Guo

Dissertations, Theses, and Masters Projects

Changes in the ionic and dipolar molecular mobility in a polymer system are the basis for the changes in the dielectric mechanical properties of polymer materials. Frequency Dependent Dielectric Measurements (FDEMS) and Ion Time-of-Flight (ITOF) are two important techniques to investigate ionic and dipolar molecular mobility in polymer systems. The results can be related to the macro- and molecular dielectric, electrical and dynamic properties of polymeric materials. The combination of these two methods provides a full view of electric, dielectric and dynamic behavior for the systems as they undergo chemical and/or physical changes during polymerization crystallization, vitrification, and/or phase separation.;The …

High Performance Liquid Chromatography Diastereomeric Separation For Chiral Analysis And Kinetic Analysis, Li Li

Seton Hall University Dissertations and Theses (ETDs)

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Heavy Metal Complexes Of Mixed S,N Donor Ligands: X-Ray Crystallography And Solution-State 1h Nmr, Wei Lai

Dissertations, Theses, and Masters Projects

No abstract provided.

Mechanism Of Ion-Pair Chromatography And Chromatographic Behavior Of Liophilic Ions, Irina Leonidovna Kazakevich

Seton Hall University Dissertations and Theses (ETDs)

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Characterization And Design Of A Molecular Imprinted Polymer For Cinchona Alkaloids, William P. Fish

Seton Hall University Dissertations and Theses (ETDs)

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