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Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen
Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen
Electronic Thesis and Dissertation Repository
Colloidal inorganic nanoparticles (NPs) have been attracting considerable interest in biomedicine, from drug and gene delivery to imaging, sensing and diagnostics. It is essential to modify the surface of nanoparticles to have enhanced biocompatibility and functionality for the in vitro and in vivo applications, especially in delivering locally and recognizing biomolecules. Herein, the goal of this research work is to develop advanced NPs with well-tailored surface functionalities and/or bio-functionality for the applications in cell tracking and analytes detection.
In the first project, quantum dots incorporating with gelatin nanoparticles (QDs-GNPs) have been developed for bioimaging applications. Two different approaches have been …
Electrochemiluminescence Of Thienyltriazoles, Iridium Complexes, Au25 Clusters And Pbs Nanoparticles, Kalen N. Swanick
Electrochemiluminescence Of Thienyltriazoles, Iridium Complexes, Au25 Clusters And Pbs Nanoparticles, Kalen N. Swanick
Electronic Thesis and Dissertation Repository
Electrogenerated chemiluminescence or electrochemiluminescence (ECL), produces light in the vicinity of a working electrode by the excited species of a luminophore formed via electron transfer between radical cations and anions, which are electrogenerated. In order for the ECL system to be efficient, the radicals must be stable in solution. This can be enhanced by adding co-reactants such as benzoyl peroxide (BPO) and tri-n-propylamine (TPrA) that produce strong oxidizing or reducing radicals upon redox reactions. ECL pairs electrochemical and spectroscopic methods and is a powerful analytical technique that is highly sensitive and selective.
A comprehensive, mechanistic study of ECL …