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Striatal Dopamine Dynamics Upon Manganese Accumulation, Madiha Khalid
Striatal Dopamine Dynamics Upon Manganese Accumulation, Madiha Khalid
Wayne State University Dissertations
STRIATAL DOPAMINE DYNAMICS UPON MANGANESE ACCUMULATION
by MADIHA KHALID
August 2013
Advisor: Dr. Tiffany Mathews
Major: Chemistry (Analytical)
Degree: Doctor of Philosophy
Although manganese (Mn) is fundamental for many biological processes, exposure to excess amounts leads to a neurological disorder termed manganism. Due to its symptomatic similarity to Parkinson's disease, as well its preferential accumulation in dopamine rich brain regions, alterations in the dopamine system are implicated in the onset of manganism. In my research, Mn overexposure is mimicked via subcutaneous administration of manganese chloride to C57BL/6 mice over the course of seven days using a protocol that has been …
Investigation Of Dopamine Dynamics In Bdnf+/- Mice Using In Vivo Microdialysis And Electrochemical Analysis Of Purine And Monoamine Molecules Using A Boron-Doped Diamond Electrode, Johnna A. Birbeck
Wayne State University Dissertations
The goal of the first study was to determine if a reduction in brain-derived neurotrophic factor (BDNF) levels in female mice lead to a dysregulation in their dopaminergic system. Through a series of in vivo microdialysis and slice voltammetry experiments, we have discerned that female BDNF+/- mice are hyperdopaminergic similar to their male BDNF+/- counterparts. The in vivo microdialysis method zero-net flux highlighted that female BDNF+/- mice had increased extracellular dopamine (DA) levels, while stimulated regional release by high potassium potentiated DA release from vesicular mediated depolarization. Using the complementary technique of fast scan cyclic voltammetry, electrical …