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Advanced Analytical Techniques For The Analysis Of Therapeutics Of Toxic Inhalation Agents And Pharmacokinetic Investigation, Subrata Bhadra

Electronic Theses and Dissertations

Toxic inhalation agents (TIAs), (i.e., cyanide (CN) and reduced sulfur compounds (RSCs)), including hydrogen sulfide (H2S) and methanethiol (MT)) are extremely poisonous upon exposure. Many TIAs act by inhibiting mitochondrial cytochrome c oxidase, resulting in cellular hypoxia, cytotoxic anoxia, apnea, respiratory failure, cardiovascular collapse, seizure and potentially death. CN is generated in structural fires and cigarette smoke as well as in mining, electroplating and polymer processing, whereas H2S and MT are found in petroleum, oil and natural gas, waste treatment facilities and decaying organic matter. All are common occupational gas exposure hazards in chemical industries and for first responders, including …