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Full-Text Articles in Physical Sciences and Mathematics
Differential Methylation Methods In Multi-Context Organisms, Douglas Baumann, Yuqing Su, Iranga Mendis, Gayla R. Olbricht
Differential Methylation Methods In Multi-Context Organisms, Douglas Baumann, Yuqing Su, Iranga Mendis, Gayla R. Olbricht
Conference on Applied Statistics in Agriculture
DNA methylation is an epigenetic modification that has the ability to alter gene expression without any change in the DNA sequence. DNA methylation occurs when a methyl chemical group attaches to cytosine bases on the DNA sequence. In mammals, DNA methylation primarily occurs at CG sites, when a cytosine is followed by a guanine in the DNA sequence. In plants, DNA methylation can also occur in other cytosine sequences, such as when a cytosine is not followed directly by a guanine. Many of the statistical methods that have been developed to estimate methylation levels and test differential methylation in whole-genome …
A Two-Stage Approach For Estimating The Effect Of Dna Methylation On Differential Expression Using Tiling Array Technology, Suk-Young Yoo, R. W. Doerge
A Two-Stage Approach For Estimating The Effect Of Dna Methylation On Differential Expression Using Tiling Array Technology, Suk-Young Yoo, R. W. Doerge
Conference on Applied Statistics in Agriculture
Epigenetics is the study of heritable alterations in gene function without changing the DNA sequence itself. It is known that epigenetic modifications such as DNA methylation and histone modifications are highly correlated with the regulation of gene expression. A twostage analysis is proposed that employs a hidden Markov model and a linear model to evaluate differential expression as related to DNA methylation for the purpose of examining the effects of DNA methylation on gene regulation using tiling array technology. In the first stage, a hidden Markov model (HMM) is employed to estimate the methylation status per tile by utilizing information …