Veterinary Toxicology and Pharmacology Commons^™

Pharmacokinetics Of Orally Administered Prednisolone In Alpacas, Ricardo Videla, Carla Sommardahl, Joseph Smith, Deanna M.W. Schaeffer, Sherry Cox

Faculty Publications and Other Works -- Large Animal Clinical Sciences

This study aimed to determine the pharmacokinetics of prednisolone following intravenous and oral administration in healthy adult alpacas. Healthy adult alpacas were given prednisolone (IV, n = 4), as well as orally (PO, n = 6). Prednisolone was administered IV once (1 mg/kg). Oral administration was once daily for 5 days (2 mg/kg). Each treatment was separated by a minimum 4 month washout period. Samples were collected at 0 (pre-administration), 0.083, 0.167, 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, and 24 h after IV administration, and at 0 (pre-administration), 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, 24 after …

Pharmacokinetics Of Pantoprazole And Pantoprazole Sulfone In Goats After Intravenous Administration: A Preliminary Report, Joseph Smith, Jonathan P. Mochel, Windy M. Soto-Gonzalez, Rebecca R. Rahn, Bryanna M. Fayne, Olivia G. Escher, Anastasia M. Geletka, Lainey E. Harvill, Joan B. Bergman, Sherry Cox

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats.

Objective: The primary study objective was to estimate the plasma pharmacokinetic parameters for pantoprazole in adult goats after intravenous administration. A secondary objective was to describe the pharmacokinetic parameters for the metabolite, pantoprazole sulfone, in goats.

Methods: Pantoprazole was administered intravenously to six adult goats at a dose of 1 mg/kg. Plasma samples were collected over 36h and analyzed via reverse phase high performance liquid chromatography for determination of pantoprazole …

Pharmacokinetics Of Tulathromycin In Pregnant Ewes (Ovis Aries) Challenged With Campylobacter Jejuni, Michael Yaeger, Jonathan P. Mochel, Zuowei Wu, Paul Plummer, Orhan Sahin, Joseph Smith, Melda Ocal, Ashenafi Beyi, Changyun Xu, Qijing Zhang, Ronald W. Griffith

Faculty Publications and Other Works -- Large Animal Clinical Sciences

The purpose of this study was to evaluate the pharmacokinetics of tulathromycin in the plasma and maternal and fetal tissues of pregnant ewes when administered within 24 hours of a single, IV Campylobacter jejuni (C. jejuni) challenge. Twelve, pregnant ewes between 72–92 days of gestation were challenged IV with C. jejuni IA3902 and then treated with 1.1 ml/45.36 kg of tulathromycin subcutaneously 18 hours post-challenge. Ewes were bled at predetermined time points and euthanized either at a predetermined time point or following the observation of vaginal bleeding or abortion. Following euthanasia, tissues were collected for bacterial …