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Full-Text Articles in Veterinary Toxicology and Pharmacology
Phenylbutazone In The Horse: A Review, Thomas Tobin, S. Chay, S. Kamerling, W. E. Woods, T. J. Weckman, J. W. Blake, P. Lees
Phenylbutazone In The Horse: A Review, Thomas Tobin, S. Chay, S. Kamerling, W. E. Woods, T. J. Weckman, J. W. Blake, P. Lees
Maxwell H. Gluck Equine Research Center Faculty Publications
Phenylbutazone is an acidic, lipophilic, nonsteroidal anti-inflammatory drug (NSAID). It is extensively metabolized in the horse. The metabolites so far identified, oxyphenbutazone, y-hydroxyphenylbutazone and y-hydroxyoxyphenbutazone. account for some 25-30% of administered dose over 24 h. The plasma half-life of phenylbutazone and termination of its pharmacological action are determined primarily by its rate of hepatic metabolism. Phenylbutazone acts by inhibiting the cyclooxygenase enzyme system, which is responsible for synthesis of prostanoids such as PGE?. It appears to act on prostaglalidin-H synthase and prostacyclin synthase, after conversion by prostaglandin-H synthase to reactive intermediates. It markedly reduces prostanoid-dependent swelling, edema, erythema, and hypersensitivity …
Drugs And The Performance Horse, Thomas Tobin
Drugs And The Performance Horse, Thomas Tobin
Veterinary Science Books
This book presents an unprecedented account of the actions, effects and consequences of drug use in performance horses. Written for horsemen by a veterinarian and world authority on equine drugs, it deals with all classes, types, and uses of drugs. Professor Tobin describes how the drugs act, how they influence performance, and the problems they may cause. He explains the drug testing process and presents the best information available on the clearance times for drugs in horses. The text is written in plain language and with a touch of humor.