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Full-Text Articles in Large or Food Animal and Equine Medicine
Differential Gene Expression In Equine Cartilaginous Tissues And Induced Chondrocytes, Emma N. Adam
Differential Gene Expression In Equine Cartilaginous Tissues And Induced Chondrocytes, Emma N. Adam
Theses and Dissertations--Veterinary Science
Degenerative joint disease, or osteoarthritis, is a major cause of lameness and morbidity in horses, humans, and dogs. There are no truly satisfactory cures for this widespread problem and current treatments all have limitations or unwanted side effects.
New cell-based strategies to repair joint surface lesions have generated a high level of interest, but have yet to achieve the full restoration of articular cartilage structure and function. Currently used therapy cells include autologous chondrocytes and adult mesenchymal cells such as bone marrow derived cells and adipose derived cells. Unfortunately, the resultant repair tissue is biomechanically inferior fibrocartilage. A critical gap …