Large or Food Animal and Equine Medicine Commons^™

Absence Of Detectable Pharmacological Effects After Oral Administration Of Isoxsuprine, J. Daniel Harkins, G. D. Mundy, S. Stanley, W. E. Woods, R. A. Sams, D. R. Richardson, S. C. Grambow, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To deflne the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCI (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin …