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Cannabinoid Receptor Type 2 Agonist Jwh-133 Deteriorates The Liver Toxicity Induced By Cypermethrin*, Hi̇dayet Tutun, Emi̇ne Baydan
Cannabinoid Receptor Type 2 Agonist Jwh-133 Deteriorates The Liver Toxicity Induced By Cypermethrin*, Hi̇dayet Tutun, Emi̇ne Baydan
Turkish Journal of Veterinary & Animal Sciences
Cannabinoid receptor 2 (CB2) has a role in the pathology of some liver diseases. Cypermethrin (CYP) is a synthetic pyrethroid insecticide used commonly for the control of pests and vectors, and for protection of foodstuffs. In this study, the involvement of CB2 in CYP-induced liver damage in rats was investigated. CYP was applied to rats orally at a dose of 125 mg/kg bw per day for 14 days. CB2 agonist JWH-133 was administered by intraperitoneal injection at a dose of 3 mg/kg bw per day for the last 4 days of CYP toxicity. JWH-133 deteriorated the liver damage induced by …