Veterinary Medicine Commons^™

Revisión De Fisiopatología, Diagnóstico Y Terapéutica De Pénfigo Foliáceo En Caninos, Cindy Katherin Camelo Cifuentes

Medicina Veterinaria

El pénfigo foliáceo es una patología de carácter dermatológico autoinmune que pertenece al Complejo Pénfigo, es de baja presentación según los reportes de caso encontrados en revisión de literatura y es esta la forma más frecuente de presentación clínica en los animales domésticos dentro del complejo. Ha sido asociado a factores medicamentosos, dermatopatías crónicas, exposición a radiación UV, entre otros. Dentro de la fisiopatología se presenta un proceso de acantólisis que se define como la ruptura de aquellas conexiones de tipo desmosomal que unen a los queratinocitos, ligada a la producción de autoanticuerpos característica de algunas patologías autoinmunes. La presentación …

Absorption And Utilization Of Choline And Vitamin B12 In Lactating Dairy Cows Using Different Delivery Methods, Virginia Maria Artegoitia Etcheverry

Doctoral Dissertations

Choline and vitamin B12 are essential nutrients for growth and performances of production animals. However, both nutrients are extensively degraded during digestion in the rumen. This thesis comprised three experiments. First, four cows equipped with a rumen cannula and catheters in the portal vein and a mesenteric artery received a post-ruminal bolus of: 1) cyanocobalamin (CN-CBL) alone (0.1 g) [gram], 2) CN-CBL (0.1 g) + casein (10 g) or 3) CN-CBL (0.1 g) + whey proteins (10 g). After the bolus, blood samples were taken until 24 h [hour] post-bolus. The intestinal absorption of CN-CBL was greater when the vitamin …

Effect Of Small Interfering Rnas On In Vitro Replication And Gene Expression Of Feline Coronavirus, Eman Ahmed Mohamed Anis

Doctoral Dissertations

Feline corononavirus (FCoV) infection is ubiquitous in domestic cat populations worldwide and is usually associated with subclinical or mild enteritis. However, in some cats infection may result in the development of a fatal progressive disease called feline infectious peritonitis (FIP). FIP is considered to be the major cause of infectious-related death in pet cats. Currently, there is no protective vaccine or curative treatment to this highly fatal disease. In this study, we evaluated the ability of small interfering RNAs (siRNAs) to inhibit the in vitro viral replication and gene expression of FCoV as a potential treatment for FIP.

Five synthetic …

Evaluation Of Porcine Ipec-J2 Cell Line Growth Rate And Immune Response To E. Coli (0111:B4) Lps, Xiaofan Wang

Graduate Theses and Dissertations

The objective of this study was to evaluate the intestinal porcine epithelial cell-jejunum 2 (IPEC-J2) cell line as a model to study the innate immune function of live pigs. Growth rates of IPEC-J2 cells in T-75 flasks and 96-well plates were evaluated using a hemocytometer and spectrophotometer for cell quantity measurements to determine growth rate and doubling time. Growth rates of IPEC-J2 cells in T-75 flasks and 96-well plates were 0.4016 and 0.2851 times of doubling/day respectively with a doubling time of 1.73 d and 2.43 d, respectively. Confluent IPEC-J2 monolayers were tested at five time intervals (0, 1, 2, …

Effect Of A Core Conditioning Program On Lumbar Paraspinal Area, Asymmetry And Pain Score In Military Working Dogs With Lumbosacral Pain, Andrea Leigh Henderson

Masters Theses

Introduction: Lumbosacral pain and stenosis are common causes of retirement from duty for Military Working Dogs (MWDs). Working dogs that receive surgical management for this condition often have a poor prognosis for return to duty after recovery. Humans with chronic low back pain demonstrate paraspinal muscle asymmetry, pain and dysfunction that often improve in response to an exercise program. This study investigated whether dogs with mild lumbosacral pain have decreased lumbar paraspinal muscle area, symmetry, and density, as well as increased pain and dysfunction compared to control dogs. Additionally, response of pain and dysfunction to an exercise program was assessed. …

Differentiation Of Equine Mesenchymal Stromal Cells Into Cells Of Neural Lineage And Their Application Into A Novel Model For Acute Peripheral Nerve Injury In The Horse, Claudia Cruz

Masters Theses

Studies have shown that mesenchymal stromal cells (MSCs) are able to differentiate into extra-mesodermal lineages, including neurons. Positive outcomes were obtained after transplantation of neurally-induced MSCs in rats, rabbits and guinea pigs after nerve injury, but the effect of these cells is unknown in horses. Our objective was to test the ability of equine mesenchymal stromal cells to differentiate into cells of neuronal lineage, and to assess differences, if any, in morphology and protein expression. Additionally, we wanted to investigate if horse age and cell passage number contributed to the ability to achieve neural differentiation.

The first part of this …

Influencia De La Altura En La Producción Lagrimal Y Presión Intraocular En Caninos Canis Lupus Familiaris: Estudio Piloto, Estefania Bechara Arango

Medicina Veterinaria

El presente estudio se realizó para determinar la influencia de la altura (metros sobre el nivel del mar) sobre la producción de porción acuosa de la película lagrimal y la presión intraocular (PIO) en caninos. El estudio se realizó en Colombia en las ciudades de Cartagena de Indias (0m.s.n.m) y Bogotá (2.640m.s.n.m). Se tomaron mediciones de producción de la porción acuosa de la lagrima y PIO en 50 caninos machos enteros clínicamente sanos (100 ojos), distribuidos en dos grupos de 25 caninos (n=50) para cada ciudad. Los datos fueron analizados estadísticamente mediante la aplicación del test Tstudent con un nivel …

Review Of The Pathogenesis And Treatment Of Acute Spinal Cord Injury And Investigation Into The Use Of Urine 3-Hpma As A Novel Biomarker Of Secondary Injury After Acute Spinal Cord Injury In The Dog, Andrea Sangster

Open Access Theses

Acute spinal cord injury (ASCI) has two pathophysiological stages of injury: the primary injury and the secondary injury cascade. Primary injury includes the initial or mechanical insult to the spinal cord. Secondary injury is a cascade of biochemical events that propagates damage of adjacent, healthy tissue increasing the overall volume of spinal cord tissue that is affected. Acrolein is a toxic byproduct of lipid peroxidation produced during secondary injury. A metabolite of acrolein-glutathione adduct found in urine, 3-HPMA, has recently been shown to increase after spinal cord injury in a rat model. The aim of our study was to apply …

The Effects Of Heat Stress On Immunity In Laying Hens And Dairy Cattle, Rebecca Ann Strong

Open Access Theses

With the increase in global climate change and the population growth driving the high demand for additional food production, heat stress (HS) is a major concern in the livestock industry across all species. Animals experience HS when exposed to high environmental temperatures outside their thermal neutral zone. The level of the effects can vary due to the length and intensity of HS to which the animal is exposed to. In experiment one, laying hens with access to cooled perches during HS had a lower heterophil to lymphocyte ratio compared to the control hens after 4 h of acute heat stress, …

Prediction Of Parturition And Dystocia In Holstein-Friesian Cattle, And Cesarean Section In Dystocic Beef Cattle, Wen Han Mark Hiew

Open Access Dissertations

Dystocia is a major problem in the dairy industry as it causes livestock and economic loss. It is more frequently seen in primiparous cattle compared to their multiparous counterparts due to their smaller stature and the slow maturation of pelvic dimensions. In some instances, human intervention of the parturition process is imperative to avoid pain, injury, and mortality of the neonate and the dam. The ability to accurately predict dystocia and the time of parturition will ensure that timely assistance can be given to animals that are of high risk of dystocia.^ The present thesis contains four studies that explore …

A Study To Determine Student Perceptions Of The Cal Poly Veterinary Clinic, Fallon Bliss Sheridan

Master's Theses

The purpose of this study was to determine the important benefits of Cal Poly Veterinary Clinic (CPVC) and establish areas of interest for the students at the CPVC. The CPVC is a student run veterinary clinic that exposes students to teachable hands-on veterinary experiences by addressing the needs of animals on campus as well as animals in the San Luis Obispo.

This study thoroughly investigated the student who have taken or are currently taking any of the five courses taught at the CPVC. The research was accomplished through a survey questionnaire. The student questionnaire was conducted by the researcher at …

Cut-Off Values For Gait Variables To Detect Forelimb Lameness In Individual Dogs, Jennifer G. Carr

Open Access Theses

The objective of this study was to characterize kinetic and kinematic variables in dogs with forelimb lameness and determine lameness cutoff values of gait variables using ROC analysis with observational gait analysis (OGA) as reference. Twenty client-owned dogs with unilateral lameness were included. Dogs underwent orthopedic exam, including OGA, and instrumented gait analysis (IGA; kinetic and kinematic analysis). Kinetic variables with the highest accuracy were PVF and %WD with an area under the curve (AUC) of 0.73 and 0.92, respectively. Optimal cutoff value for PVF and %WD were ≤ 10.6 (sensitivity 70% and specificity 75%) and ≤ 29.7 (sensitivity 90% …

Pharmacokinetics And Toxicity Of The Novel Oral Demethylating Agent Zebularine In Laboratory And Tumor Bearing Dogs, Christopher Michael Fulkerson

Open Access Theses

The aim of this thesis is to investigate the pharmacokinetics and toxicity of the novel oral demethylating agent zebularine (zeb) in laboratory dogs and tumor bearing dogs. This thesis focuses on the application of this therapeutic strategy in dogs with naturally occurring invasive transitional cell carcinoma (InvTCC), which serve as a relevant model of the human disease.

DNA hypermethylation in the promoter region is a common epigenetic change in cancer that silences tumor suppressor genes. Zeb is an oral cytidine analog that acts as a demethylating agent. Zeb has been investigated extensively in vitro as well as in mice, rodents …

Clinical Investigation Of Plethysmographic Variability Index: A Derivative Index Of Pulse Oximetry In Anesthetized Dogs, Vaidehi V. Paranjape

Open Access Theses

Plethysmographic Variability Index (PVI) is a derivative index of pulse oximetry that allows evaluating an individual's intravascular volume status. Perfusion Index (PI) represents the strength of pulse signal at the anatomic site of measurement from which PVI is calculated using changes in PI over respiratory cycles. Plethysmographic Variability Index has been used to detect hypovolemia and predict fluid responsiveness in mechanically ventilated human patients however, fewer studies are available in spontaneously breathing patients. The use of PVI has not been explored extensively in dogs so far. The goals of this study were to establish a common range for PVI and …

Desarrollo De Un Modelo In Vitro Para Evaluar Insecticidas En La Pulga Ctenocephalides Felis, Natalia Del Pilar Cuervo Bonilla, Lina Maritza Tellez Cotamo

Medicina Veterinaria

La pulga Ctenocephalides felis es un ectoparásito vector de múltiples enfermedades que afecta a perros y gatos, tiene una distribución a escala mundial y se ha convertido en una plaga importante del ser humano y animales domésticos. Este ectoparásito, ha adaptado su ciclo biológico en ambientes domésticos y peri domésticos por su alta tasa de reproducción e infestación, lo cual la convierte en una plaga de importancia médica y veterinaria. Esta adaptación involucra su capacidad para generar resistencia a la amplia gama de insecticidas que ofrece el mercado. Ante la importancia de entender mejor la bioecología de la pulga C. …

Characterization Of Corynebacterium Pseudotuberculosis Biovar Equi Isolates Obtained From Cal Poly Horses And Review Of Application Of Transposons To Better Prevent Pigeon Fever In Horses, Irene Hasen

Animal Science

No abstract provided.

Identificación De Ectoparásitos Del Orden Phthiraptera En Aves Silvestres De La Especie Nycticorax Nycticorax, Sylvia Lorena Arévalo Barreto, Andrea Saavedra Orjuela

Medicina Veterinaria

Las aves silvestres ocupan una posición muy importante en la biodiversidad nacional, pues están representadas por una amplia riqueza de especies habitando en el territorio colombiano. En este trabajo se identificaron los ectoparásitos de aves Nycticorax nycticorax, colectados en una investigación anterior. Para ello, previamente se capturaron 7 aves Nycticorax nycticorax en la Guajira y se colectaron sus ectoparásitos; todo esto en el marco del proyecto "Implementación del Plan Nacional Sectorial Ambiental de Vigilancia y Prevención de Influenza Aviar en Especies Silvestres en Humedales Priorizados en las Regiones Caribe, Pacífico, Oriental y Sur” realizada por el Ministerio de Ambiente y …

Análisis De La Adopción De Las Buenas Prácticas Ganaderas Bpg En Fincas Certificadas A Partir Del Año 2010 En El Municipio De Guatavita, Luisa Fernanda Gómez Reyes

Medicina Veterinaria

Cuando se miran los parámetros mundiales de producción de alimentos hoy en día, no solamente se busca aumentar la ganancia económica, sino producir alimentos sanos y seguros aplicando el concepto “de la granja a la mesa”. La falta de información o conocimiento, de la aplicación de las Buenas Prácticas Ganaderas (BPG) en la Sabana de Bogotá, impacta directa e indirectamente la salud pública en el contexto de la producción ganadera y la salud humana. Este estudio tuvo como objetivo general, analizar la implementación y uso de las BPG en fincas seleccionadas del municipio de Guatavita. El instrumento de recolección de …

Effect Of A Leucine/Pyridoxine Nutraceutical On Energy Metabolism And Satiety In Lean And Obese Dogs, Maryanne Murphy

Doctoral Dissertations

Obesity is the most common nutritional disorder of pet dogs (prevalence of 23–59%). This 29-week study investigated a nutraceutical containing 1 g leucine and 13 mg pyridoxine designed to maintain lean muscle mass while decreasing adiposity when compared with positive and negative controls. After determining individual maintenance calorie requirements over 3 – 4 weeks, thirty-six healthy adult Beagles were divided into obesification, weight gain prevention, or maintain ideal body weight arms.

Obesity was induced and during a weight loss phase, excess calories were removed, and obesification dogs were given nutraceutical with CAD (ObN), placebo with CAD (ObP), or a therapeutic …

Isoflupredone Acetate As Ancillary Therapy For Bovine Respiratory Disease In High-Risk Stocker Calves, Claire E. Crews

Animal Science Undergraduate Honors Theses

Bovine respiratory disease (BRD) is the leading cause of illness and death in U.S. feedlot cattle. This study evaluated the use of isoflupredone acetate in the treatment of BRD. Crossbred male beef calves (n = 192; BW = 221 ± 3.9 kg) were acquired in two blocks from regional auction markets and transported to the University of Arkansas Stocker and Receiving Cattle Unit. Calves were observed daily for signs of respiratory illness. Antibiotic treatment was administered if calves displayed signs of respiratory illness and rectal temperature was ≥ 40 °C. Calves (n = 72) requiring antibiotic treatment were assigned randomly …

Antiviral Activity Of Favipiravir (T-705) Against Lethal Rift Valley Fever Virus Infection In Hamsters, Dionna Scharton

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Rift Valley fever (RVF) is a severe disease affecting both humans and a number of agriculturally important livestock species. The causative agent, RVF virus (RVFV), is primarily transmitted through mosquito bites, with transmission also occurring by exposure to infectious aerosols and direct contact with infected body fluids such as blood. Presently, there are no licensed vaccines or medicines to prevent or treat severe RVFV infection in humans. Favipiravir (T-705) is a novel compound licensed for the treatment of influenza in Japan and presently in Phase III clinical trials in the US, which has demonstrated favorable activity against an attenuated strain …

Chitosan Reduces Enteric Colonization Of Campylobacter In Young Chickens, But Not On Post-Harvest Chicken Skin Samples, Hanna Royce Arambel

Graduate Theses and Dissertations

Worldwide, Campylobacter is one of the leading causes of foodborne bacterial gastroenteritis causing an estimated 1.3 million infections in the United States alone. Consumption and/or cross-contamination of raw or undercooked poultry products have been linked as the most common source of Campylobacter infection, making the poultry industry a target for Campylobacter reduction strategies. Campylobacter is prevalent in most poultry flocks in the United States, with as many as 90% of flocks Campylobacter-positive at the time of slaughter. It is estimated that a reduction of Campylobacter in poultry would greatly reduce the risk of campylobacteriosis in humans. Unfortunately, there are …

The Spread And Potential Control Of Disease Across The Domestic Cattle-Wildlife Interface, Rachel Jackson

Chancellor’s Honors Program Projects

No abstract provided.

Biological Variation Of Thromboelastography Variables In Ten Healthy Female Horses, Jennifer Lee Scruggs

Masters Theses

Biological variability (BV) has important applications in laboratory medicine. It can be a source of variation in measured analyte values and provide guidance on reference interval use. BV has three components: between-individual variation (CVg), caused by differences in mean values of a particular analyte among members of a group, within-individual variation (CVi), caused by fluctuations around an individual’s inherent homeostatic set point, and analytical variation (CVa). Thromboelastography (TEG), a type of viscoelastic coagulation analysis, is becoming increasingly common in veterinary referral centers. Despite increased popularity, the optimal method of results interpretation is not clear. While population-based reference intervals (PRI) are …

Evaluación Del Conocimiento Y La Percepción Sobre Las Zoonosis Asociadas A Caninos En Propietarios De Mascotas En Las Localidades De Usaquén Y Usme, Diana Carolina Villarraga Herrera, Ivonne Melissa Vargas Rodríguez

Medicina Veterinaria

En los últimos años se ha observado la emergencia y reemergencia de algunas enfermedades zoonóticas, fenómeno estrechamente relacionado a cambios ecológicos, climáticos y socioculturales que han determinado que la población animal comparta su hábitat con el hombre con mayor frecuencia. Actualmente, se estima que el 43,6% de las zoonosis asociadas al canino, presentan distribución mundial; por lo que se necesita de la epidemiologia participativa para evaluar el conocimiento y percepción que tienen las personas acerca de las enfermedades transmitidas por sus mascotas, su implicación, y prevención por medio de prácticas básicas higiénico sanitarias. Se requiere crear conciencia, conocimiento y educación …

Medición De La Eficiencia Entre El Diagnóstico Del Chequeo Reproductivo Por Palpación Rectal, Ecografía Y Niveles Séricos De Progesterona, Andrés Trujillo Piedrahita, Sandra Liliana Peña Marentes

Medicina Veterinaria

El diagnóstico reproductivo de bovinos en campo se basa en la palpación rectal, los médicos veterinarios diagnostican estructuras ováricas como folículos y cuerpos lúteos, la problemática que se presenta cuando se realizan estos diagnósticos es que cada médico veterinario tiene una opinión subjetiva, las medidas de los cuerpos lúteos encontrados son diferentes para cada uno y no todos los cuerpos lúteos que se diagnostican como grandes son funcionales. En general del proyecto se basa en medir la eficiencia del chequeo reproductivo mediante palpación rectal en la evaluación clínica de los cuerpos lúteos hallados, evaluando vacas con ciclos normales con más …

Cd4 Silencing In Thymocytes Is Opposed By The Enforced Association Of P300 Hat, Hdac1 Or Suv39h1 With Runx Transcription Factors, Christyne Ayne Kane

Doctoral Dissertations

The transcription factors Runx1 and Runx3 are required for permanent silencing of CD4 in maturing CD8+ thymocytes. Runx binding to consensus sites within the CD4 silencer region is required for CD4 silencing post-positive selection. The Runx nuclear matrix targeting sequence (NMTS) is required for CD4 silencing and is implicated in binding to the histone acetyltransferase (HAT) p300, histone deacetylases (HDAC), and histone methyltransferase (HMT) SUV39H1 proteins. Epigenetic modifications of chromatin or post-translational modifications of Runx itself as a result of Runx association with these enzymes may be important for establishment of long-term CD4 silencing. In this study, we show that …

Evaluation Of Wing Fractures On Survival And Re-Release, Katherine O'Neill

Animal Science

No abstract provided.

Using Progesterone As An Indicator Of Ovarian Response To Stimulation In Cattle, Kayla Mariah Kauffman

Animal Science

No abstract provided.

Determinación De La Eficacia En El Mejoramiento Productivo A Partir Del Uso De Un Producto Inyectable A Base De Vitaminas, Aminoácidos, Electrolitos, Minerales Y Ácidos Grasos En Cerdos De Levante Y Ceba, En Silvania Cundinamarca, Natalia Bohórquez Amaya

Medicina Veterinaria

Este proyecto nace de la necesidad de establecer una prueba de eficacia para un producto inyectable a base de vitaminas, aminoácidos, electrolitos, minerales y ácidos grasos en porcinos de ceba y levante. Con el fin de establecer las bondades de estos elementos en la ganancia de peso diario y en la producción de carne porcina sin el empleo de anabólicos, es decir un sistema de producción limpia que garantice una inocuidad alimentaria. Estos estudios se han realizado en especies como los bovinos (FLOREZ, 2008), pero aún no hay un estudio completo del uso de estos aminoácidos, vitaminas, electrolitos, minerales y …