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All-Trans Retinoic Acid Regulates Intracellular Redox Status In Marc-145 Cells Infected With Porcine Reproductive And Respiratory Syndrome Virus, Yan Lin, De Wu
All-Trans Retinoic Acid Regulates Intracellular Redox Status In Marc-145 Cells Infected With Porcine Reproductive And Respiratory Syndrome Virus, Yan Lin, De Wu
Turkish Journal of Veterinary & Animal Sciences
A relationship between oxidative stress, and apoptosis and/or death has been suggested for many years. The objective of this study was to determine the influence of all-trans retinoic acid (ATRA) on the cell survival rate and the antioxidant defense system. MARC-145 cells were treated with ATRA after infection with porcine reproductive and respiratory syndrome virus (PRRSV). The cell survival rate, total antioxidant capability (T-AOC), glutathione peroxidase (GSH-P_X) activity, superoxide dismutase (SOD) activity, lactate dehydrogenase (LDH) activity, and glutathione (GSH) content were determined in samples collected from cells incubated with ATRA for 24 or 48 h. The results show that PRRSV …