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Full-Text Articles in Veterinary Medicine
The Effect Of Low-Level Laser Therapy On Rat Unicortical Femoral Defect, Latif Emrah Yanmaz, Ugur Ersoz, Sitkican Okur, Betul Apaydin Yildirim, Selim Comakli, Yavuz Selim Sağlam, Elif Dogan, Ozhan Karatas, Ferda Turgut, Zafer Okumuş
The Effect Of Low-Level Laser Therapy On Rat Unicortical Femoral Defect, Latif Emrah Yanmaz, Ugur Ersoz, Sitkican Okur, Betul Apaydin Yildirim, Selim Comakli, Yavuz Selim Sağlam, Elif Dogan, Ozhan Karatas, Ferda Turgut, Zafer Okumuş
The Thai Journal of Veterinary Medicine
The aim of this study was to determine the effectiveness of low-level laser therapy (LLLT) in the healing of experimentally created unicortical defect (UCD) of rat femurs. Twenty-four adult Wister rats were randomly divided into 2 groups: UCD and UCD+LLLT. The animals were subdivided into 3 groups (each group had 4 animals) and then they sacrificed at day 8, 15 and 22 for radiological, pathological and biochemical analysis. Bone healing was significantly different between the groups at day 15 and 22 (P < 0.05), while bone formation was significantly increased in the UCD+LLLT group at day 22 compared to the UCD group (P < 0.05). On histopathological examination, significant difference was found between the UCD and UCD+LLLT groups on the 22nd day (P < 0.05) while there was no difference on the 8th and 15th day. In the UCD group, the plasma Alkaline phosphatase activity decreased on the 15th and 22nd days, Calcium on the 15th day and Phosphorus on the 8th and 22nd days compared to the UCD+LLLT group. In addition, Glutathione levels, Plasma Catalase, Glutathione Peroxidase and Superoxide Dismutase activity significantly reduced in the UCD group compared with UCD+LLLT on the 8th, 15th and 22nd day (P < 0.05). In conclusion, LLLT applied at a dose of 904µm accelerates fracture healing in UCD of a rat’s femur. However, this effect shows an increase after the 22nd day of LLLT application.
Therapeutic Effect Of Tarantula Cubensis Extract On Indomethacin Induced Gastric Ulcers In Rats, Mustafa Makav, Volkan Gelen, Semin Gedi̇kli̇, Gözde Atila Uslu, Hamit Uslu, Hüseyin Avni Eroğlu
Therapeutic Effect Of Tarantula Cubensis Extract On Indomethacin Induced Gastric Ulcers In Rats, Mustafa Makav, Volkan Gelen, Semin Gedi̇kli̇, Gözde Atila Uslu, Hamit Uslu, Hüseyin Avni Eroğlu
The Thai Journal of Veterinary Medicine
Non-steroid anti-inflammatory drugs (NSAIDs) have widely been used in patients but side-effects associated with NSAID are also common. Tarantula cubensisextract (TCE) is an antiphlogistic, demarcative, homeopathic and necrotizing drug with wound healing effects in farm animals. However, the therapeutic effects ofTCEon gastric ulcers has not been investigated. The aim of this study was to investigate the gastroprotective effects of TCE against indomethacin-induced gastric injury in rats. A total of 28 female, Wistar albino rats were divided into four groups: (i) the control group, (ii) the indomethacin (Indo) group, (iii) the TCE + Indo group, and (iv) the ranitidine + Indo …
Effect Of Fermented Red Radish (Raphanus Sativus L) In Carbon Tetrachloride-Induced Liver Injury In Rats, Ayhan Atasever, Duygu Yaman Gram, Gorkem Ekebas, Nurhan Ertas Onmaz, Meryem Senturk, Meryem Eren, Lutfiye Ekici
Effect Of Fermented Red Radish (Raphanus Sativus L) In Carbon Tetrachloride-Induced Liver Injury In Rats, Ayhan Atasever, Duygu Yaman Gram, Gorkem Ekebas, Nurhan Ertas Onmaz, Meryem Senturk, Meryem Eren, Lutfiye Ekici
The Thai Journal of Veterinary Medicine
In this study, the possible protective effect of red radish containing total phenolic content and antioxidant components on histopathological and immuno histochemical active caspase-3, TNF-α and Iba-1, serum ALT activity, triglyceride, total cholesterol, LDL-cholesterol, liver malondialdehyde (MDA) and nitric oxide (NO) levels were evaluated in CCl4induced liver injury in Wistar rats. The rats were randomly divided into six groups (n= 12 to each group). The first group was used as a control which was given only intraperitoneal 0.9% NaCl (0.2 mL / kg / bw); while fermented red radish (FRR) at a dose of 250 mg/kg or 500 mg/kg was …
The Effects Of Pumpkin Seed Oil On Carbon Tetrachloride Induced Chronic Hepatic Damage In Rats, Ayhan Atasever, Meryem Senturk, Gorkem Ekebas, Duygu Yaman Gram, Meryem Eren
The Effects Of Pumpkin Seed Oil On Carbon Tetrachloride Induced Chronic Hepatic Damage In Rats, Ayhan Atasever, Meryem Senturk, Gorkem Ekebas, Duygu Yaman Gram, Meryem Eren
The Thai Journal of Veterinary Medicine
The present study determined the possible protective effect of pumpkin seed oil (PSO) on histopathological changes in liver tissue and serum alanine aminotransferase (ALT) activity, glucose, Non-Esterified Fatty Acids (NEFA) and triglyceride (TG) levels on chronic liver injury induced by carbon tetrachloride (CCl4) in rats. A total of 80 Wistar rats were divided into eight groups of ten rats each: the first group served as the control, group II was given intraperitoneal 0.2 mL/kg CCl4, twice a week for 8 weeks. Groups III-V were treated daily with PSO for 8 weeks (1, 2 and 3 mL/kg respectively). Groups (VI-VIII) were …
Seroprevalence And Phylogenetic Analysis Of Toxoplasma Gondii From Domestic Cats, Captive Wild Felids, Free-Range Wild Felids And Rats In Certain Regions Of Thailand, Ruangrat Buddhirongawatr, Kridsada Chaichoun, Siriporn Tungsudjai, Ruenruethai Udonsom, Andrew Thompson, Oangart Mahittikorn, Paron Dekumyoy, Yaowalark Sukthana
Seroprevalence And Phylogenetic Analysis Of Toxoplasma Gondii From Domestic Cats, Captive Wild Felids, Free-Range Wild Felids And Rats In Certain Regions Of Thailand, Ruangrat Buddhirongawatr, Kridsada Chaichoun, Siriporn Tungsudjai, Ruenruethai Udonsom, Andrew Thompson, Oangart Mahittikorn, Paron Dekumyoy, Yaowalark Sukthana
The Thai Journal of Veterinary Medicine
Toxoplasmosis is an important zoonotic disease caused by Toxoplasma gondii, an obligated zoonotic apicomplexan parasite. The infection varies according to geographical areas. This work aimed to study the seroprevalence and genotype of T. gondii infection in domestic, captive and free-range wild felids, and in their small mammal prey, rats (Rattus spp). Two hundred and ninety three sera, received from the 4 individual animal groups in Thailand, were tested using the indirect latex agglutination test (ILAT) for specific antibody detection. The nested-PCR for glycerol-3-phosphate (B1) and bradyzoite surface antigen (SAG4) gene detection was used to detect seropositive animals and PCR product …
Comparison Of Modified Warm Water Infusion And Air Insufflation For Colonoscopy In A Rat Colon Cancer Model, Mingjie Qian, Zhenyu Sui, Wen Tang, Shaofeng Wang
Comparison Of Modified Warm Water Infusion And Air Insufflation For Colonoscopy In A Rat Colon Cancer Model, Mingjie Qian, Zhenyu Sui, Wen Tang, Shaofeng Wang
The Thai Journal of Veterinary Medicine
Our aim is to compare the effect of warm water infusion and air infusion enteroscopy on the success rate of colonoscopy in a rat model of colorectal cancer. 60 rats with colorectal cancer were divided into 2 groups: the air infusion (AI) group taking air infusion enteroscopy and the warm water infusion (WWI) group taking warm water infusion enteroscopy. The success rate, testing time, pain score and diagnostic value of these two groups were evaluated. There are significant differences between two groups concerning the success rate and the average test time. In the WWI group, the success rate is 83.33% …
Response Of Gh, Acth, Tsh And Igf-I To Gonadotropin Releasing Hormone Stimulation In Ovariohysterectomized Rats, Jian-Liang Lin, Li-Shiue Shiu, Hsein-Chi Wang, Wei-Ming Lee
Response Of Gh, Acth, Tsh And Igf-I To Gonadotropin Releasing Hormone Stimulation In Ovariohysterectomized Rats, Jian-Liang Lin, Li-Shiue Shiu, Hsein-Chi Wang, Wei-Ming Lee
The Thai Journal of Veterinary Medicine
GnRH is not only a primary regulator of gonadal function but also a possible factor which affects other pituitary cells out of gonadotrophs. Recently, it has been reported that GnRH might induce the release of GH, but the effects on GH and other pituitary hormones of GnRH still remained controversial. In this study, OHE was performed in 30-week-old female Sprague Dawley rats as experimental groups. Intact female rats were taken as control group. GnRH stimulation at different weeks (20, 24, and 30) after OHE was examined in all rats. Evaluation of the circulating GH, IGF-I, ACTH, TSH concentrations at different …
Clastogenic And Anticlastogenic Potential Of Neem Flower Extract Evaluated By Rat Liver Micronucleus Assay, Piengchai Kupradinun, Yaninee Jarratwisarutporn, Rawiwan Wongpoomchai, Hathaitip Sritanaudomchai, Mati Rienkitjakarn
Clastogenic And Anticlastogenic Potential Of Neem Flower Extract Evaluated By Rat Liver Micronucleus Assay, Piengchai Kupradinun, Yaninee Jarratwisarutporn, Rawiwan Wongpoomchai, Hathaitip Sritanaudomchai, Mati Rienkitjakarn
The Thai Journal of Veterinary Medicine
Clastogenic and anticlastogenic effects of neem flower (Azadirachta indica A. Juss) extract were determined using a rat liver micronucleus assay. Methanol extracts of neem flowers (MENF) in 15% Tween 80 at 100 and 500 mg/kg body weight were orally given to male Sprague Dawley rats daily for 6 weeks (2 weeks prior to and 4 weeks during repeated administration of diethylnitrosamine (DEN). All rats were anesthetized and their livers were collected. Hepatocytes were isolated from the livers using a collagenase solution without performing liver perfusion, then stained with 4’, 6-diamidino-2-phenylindole dihydrochloride (DAPI). Incidence of the micronucleated hepatocytes was evaluated by …
Comparison Of Gentamicin Impregnated Polymethlymetacrylate Bead, Gentamicin Coated Native Calcium Sulfate Bead And Gentamicin Coated High Porous Calcium Sulfate Bead On Osteomyelitis Management In A Rat Model, Chaiyakorn Thitiyanaporn, Pareeya Udomkusonsri, Naris Thengchaisri
Comparison Of Gentamicin Impregnated Polymethlymetacrylate Bead, Gentamicin Coated Native Calcium Sulfate Bead And Gentamicin Coated High Porous Calcium Sulfate Bead On Osteomyelitis Management In A Rat Model, Chaiyakorn Thitiyanaporn, Pareeya Udomkusonsri, Naris Thengchaisri
The Thai Journal of Veterinary Medicine
Three types of gentamicin beads were compared in a rat osteomyelitis model. The gentamicin beads were prepared in cylinder shape (diameter 2 mm x height 4 mm). Gentamicin impregnated polymethylmethacrylate (GIPMMA) beads were fabricated according to manufacturer’s instructions. Gentamicin coated native calcium sulfate (GNCS) bead and gentamicin coated high porous calcium sulfate (G-HPCS) bead were prepared in laboratory. Osteomyelitis was induced in the rat’s tibias by using methicillin resistance Staphylococcus aureus (MRSA). After 3 weeks of infection, the infected tibias were implanted with GI-PMMA bead, G-NCS bead, G-HPCS bead or sham treatment (control). Radiographic change, white blood cell count and …
Acute To Subchronic Toxicity And Reproductive Effects Of Aqueous Ethanolic Extract Of Rhizomes Of Lasia Spinosa Thw. In Male Rats, Theerayuth Kaewamatawong, Wanwipa Suthikrai, Anong Bintvihok, Wijit Banlunara
Acute To Subchronic Toxicity And Reproductive Effects Of Aqueous Ethanolic Extract Of Rhizomes Of Lasia Spinosa Thw. In Male Rats, Theerayuth Kaewamatawong, Wanwipa Suthikrai, Anong Bintvihok, Wijit Banlunara
The Thai Journal of Veterinary Medicine
Acute and subchronic tests on the toxicity and reproductive effects of aqueous ethanolic extract of rhizomes of Lasia spinosa Thw. was studied in male rats. In the acute test, oral administration of 5, 10, 20, 40 g/kg of the extract showed no mortality or behavioral changes. In the subchronic test, administration of 5 or 20 g/kg of the extract for 28 days revealed no mortality of the animals. No differences in hematological parameters were observed in either control or treatment groups of both tests. For blood chemistry analysis in both tests, triglycerides in treatment rats were significantly decreased compared to …
Safety Evaluations Of Ethanolic Extract Of Moringa Oleifera Lam. Seed In Experimental Animals, Songpol Chivapat, Pornchai Sincharoenpokai, Praw Suppajariyawat, Anudep Rungsipipat, Suphan Phattarapornchaiwat, Vanida Chantarateptawan
Safety Evaluations Of Ethanolic Extract Of Moringa Oleifera Lam. Seed In Experimental Animals, Songpol Chivapat, Pornchai Sincharoenpokai, Praw Suppajariyawat, Anudep Rungsipipat, Suphan Phattarapornchaiwat, Vanida Chantarateptawan
The Thai Journal of Veterinary Medicine
The safety of ethanolic extract from the seeds of Moringa oleifera was evaluated for its oral toxicity by acute toxicity test and subchronic toxicity study in experimental animals. The acute toxicity test in mice showed that the extract at doses ranging from 5.1 to 10.0 g/kg caused toxic signs and dose dependent mortality. Oral administration of the extract in rats at doses of 100, 500 and 1000 mg/kg/day for 90 consecutive days revealed that male rats treated with the extract at 1000 mg/kg had a significant decrease in RBC but this alteration was within rats reference range. A significant decrease …
Anxiolytic-Like Effects Of Noni Juice (Morinda Citrifolia L.) On The Respective Changes Of Neurotransmitters In Rat Brain In The Elevated Plus-Maze Test, Sarinee Kalandakanond-Thongsong, Jantarima Charoenphandhu
Anxiolytic-Like Effects Of Noni Juice (Morinda Citrifolia L.) On The Respective Changes Of Neurotransmitters In Rat Brain In The Elevated Plus-Maze Test, Sarinee Kalandakanond-Thongsong, Jantarima Charoenphandhu
The Thai Journal of Veterinary Medicine
Noni (Morinda citrifolia L.) has long been used to treat various conditions in folklore medicine. Presently,most studies focus on antioxidant and anti-cancer activities while it is also claimed by noni juice-consumers toproduce happiness. Mood disorders, e.g. anxiety, are symptoms that reflected the disorder of neurotransmitters, oneof the most prominent is the monoaminergic system. Anxiety affects people throughout the world; people have beenseeking medicine for treatment while natural products may also alleviate this unfavorable symptom. The presentstudy examined whether noni contained anxiolytic-like effect when tested with elevated plus-maze (EPM), a standardtest for anxiety, and whether this effect was related to change …
Acute And Subchronic Toxicity Study Of Ardisia Ellipica Thunb. Fruit Extract, Nalinphat Saktiyasunthorn, Songpol Chivapat, Pornchai Sincharoenpokai, Anudep Rungsipipat, Nongnuth Maneechai, Boonyanee Suphaphon, Aussavashai Shuayprom
Acute And Subchronic Toxicity Study Of Ardisia Ellipica Thunb. Fruit Extract, Nalinphat Saktiyasunthorn, Songpol Chivapat, Pornchai Sincharoenpokai, Anudep Rungsipipat, Nongnuth Maneechai, Boonyanee Suphaphon, Aussavashai Shuayprom
The Thai Journal of Veterinary Medicine
Several plants species in the genus Ardisia contained various biologically active compounds. Ram Yai orPilangkasa (Ardisia elliptica Thunb.) has been used in traditional medicines. The objective of this study was to evaluatethe safety of ethanolic extract of A. elliptica fruit in animal models by oral administration. Acute toxicity test in miceby gavage the extract at each dose of 2.5 g/kg twice revealed no abnormal signs, mortality and gross lesion of vitalorgans. Subchronic toxicity study was investigated in one hundred Wistar rats separated into five groups, each oftwenty (ten males and ten females). Two control groups received distilled water and 0.5% …
Acute And Chronic Toxicity Of Moringa Oleifera Linn Leaves Extracts, Songpol Chivapat, Pornchai Sincharoenpokai, Nalinphat Saktiyasuthorn, Aussavachai Shuaprom, Pratom Thongsrirak, Apirak Sakpetch, Anudep Rungsipipat
Acute And Chronic Toxicity Of Moringa Oleifera Linn Leaves Extracts, Songpol Chivapat, Pornchai Sincharoenpokai, Nalinphat Saktiyasuthorn, Aussavachai Shuaprom, Pratom Thongsrirak, Apirak Sakpetch, Anudep Rungsipipat
The Thai Journal of Veterinary Medicine
Moringa oleifera leaves have been reported to possess potential hypotensive and hypocholesterolemic andhypoglycemic activities; nevertheless toxicological data of this herb in animal models have still been scanty. Theobjective of this study was to evaluate both acute and chronic toxicity of the water extract of M. oleifera leaves by oraladministration. Acute toxicity test in mice by gavage with the extract twice, each at the dose of 10 g/kg, revealed thatthe extract produced no acute toxic symptoms and gross lesions of vital organs. Chronic toxicity study wasinvestigated in eighty Wistar rats allocated into four groups, each of ten per sex. Group 1 …
Chronic Toxicity Study Of Garcinia Mangostana Linn. Pericarp Extract, Songpol Chivapat, Pranee Chavalittumrong, Prapai Wongsinkongman, Chada Phisalpong, Anudep Rungsipipat
Chronic Toxicity Study Of Garcinia Mangostana Linn. Pericarp Extract, Songpol Chivapat, Pranee Chavalittumrong, Prapai Wongsinkongman, Chada Phisalpong, Anudep Rungsipipat
The Thai Journal of Veterinary Medicine
Ethanolic extracts from fruit pericarp of mangosteen (Garcinia mangostana L.) possess many biological andpharmacological activities. However, chronic toxicity study of ethanolic extract has never been investigated. Theobjective of this study was to evaluate the safety of 95% ethanolic extract from mangosteen pericarp in animal model.The oral administration of the extract was performed in 180 Wistar rats randomly allocated to six groups, each of15/sex. Group 1 was control group receiving distilled water. Group 2 to 6 were treatment groups receiving the extractat the doses of 10, 100, 500, 1000 and 1000 mg/kg/day for six months respectively. The last group was assigned …
Chronic Toxicity Study Of Kaempferia Parviflora Wall Ex. Extract, Songpol Chivapat, Pranee Chavalittumrong, Aimmanas Attawish, Anudep Rungsipipat
Chronic Toxicity Study Of Kaempferia Parviflora Wall Ex. Extract, Songpol Chivapat, Pranee Chavalittumrong, Aimmanas Attawish, Anudep Rungsipipat
The Thai Journal of Veterinary Medicine
K. parviflora is a medicinal plant possessing high potential for development of various health products. The objective of this chronic toxicity study was to investigate the safety of ethanolic extract of chronic Kaempferia parviflora Wall ex Bak in Wistar rats. The animals were randomly divided into five groups, twenty four rats each (12 males and 12 females). Three treatment groups were orally administered with K. parviflora extract at doses of 5, 50 and 500 mg/kg/day for six months respectively, which were equivalent to 1, 10 and 100 times of human use, while two control groups were orally given with distilled …
The Efficacy Of Pure Natural Repellents On Rat Responses Using Circular Open Field, Sarinee Kalandakanond-Thongsong, Suwaporn Daendee, Boonrit Thongsong, Vivat Chavananikul
The Efficacy Of Pure Natural Repellents On Rat Responses Using Circular Open Field, Sarinee Kalandakanond-Thongsong, Suwaporn Daendee, Boonrit Thongsong, Vivat Chavananikul
The Thai Journal of Veterinary Medicine
Rodent infestation is considered as one of the major pest problems since it is not only acting as a health hazard, but also causes damages to household, agricultural fields and even transportation business. The use of rodenticides is a common approach to rodent control, however, most rodenticides are poisonous to man. Therefore, using natural extracts as a rat repellent may be a better alternative. In the current study, various natural extracts were experimented whether they could repel a rat when testing in the behavioral model, a circular open field. The tested substances were wintergreen oil, chilli, peppermint oil, bergamot oil …
Toxicity Testing Of Flowers Of Neem Tree (Azadirachta Indica A. Juss), Piengchai Kupradinun, Anong Tepsuwan, Nopsarun Tanthasri, Nuntana Meesiripan, Sirirat Tunsakul, Warayupa Tompat, Yaninee Jarratwisarutporn, Wannee R. Kusamran
Toxicity Testing Of Flowers Of Neem Tree (Azadirachta Indica A. Juss), Piengchai Kupradinun, Anong Tepsuwan, Nopsarun Tanthasri, Nuntana Meesiripan, Sirirat Tunsakul, Warayupa Tompat, Yaninee Jarratwisarutporn, Wannee R. Kusamran
The Thai Journal of Veterinary Medicine
Flowers of neem (Azadirachta indica A. Juss) possess a strong cancer chemopreventive potential in rats as well as antimicronucleus formation in mice. However, toxicity testing has never been evaluated. This study was aimed to determine its acute and subacute toxicities in Wistar rats. Acute toxicity was conducted by feeding methanol extract of neem flowers (MENF) suspending in 20% propylene glycol at 6, 9 and 12 g/kg bw. On the other hand, subacute toxicity testing was carried out by feeding MENF suspending in 0.5% tragacanth at 150, 750 and 1,500 mg/kg bw for 90 consecutive days. Hematology, blood chemistry and histopathology …
Effects Of A Beta Adrenergic Antagonist Combined With Vasodilators On Cardiac Arrhythmia In Ischemic-Induced Rat Hearts, Promporn Raksaseri, Wuthichai Klomkleaw, Suwanakiet Sawangkoon
Effects Of A Beta Adrenergic Antagonist Combined With Vasodilators On Cardiac Arrhythmia In Ischemic-Induced Rat Hearts, Promporn Raksaseri, Wuthichai Klomkleaw, Suwanakiet Sawangkoon
The Thai Journal of Veterinary Medicine
Sixty male Spraque-Dawley rats were used in this study. The hearts were isolated and placed on a constant-pressure Langendorff apparatus, and perfused with only Krebs-Henseleit buffer (control), atenolol, atenolol plus prazosin, and atenolol plus salbutamol. After that the left anterior descending artery was occluded for 8 minutes and reperfused for 30 minutes to induce cardiac arrhythmias. The left ventricular pressure and coronary flow rate were monitored, and ECGs were recorded to evaluate cardiac arrhythmias. The administration of atenolol (β1-adrenergic antagonist) combined with prazosin (α1-adrenergic antagonist) prolonged RR intervals whereas that of atenolol combined with salbutamol (β2-adrenergic antagonist) did not prolong …