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Antiviral Activity Of Favipiravir (T-705) Against Lethal Rift Valley Fever Virus Infection In Hamsters, Dionna Scharton
Antiviral Activity Of Favipiravir (T-705) Against Lethal Rift Valley Fever Virus Infection In Hamsters, Dionna Scharton
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Rift Valley fever (RVF) is a severe disease affecting both humans and a number of agriculturally important livestock species. The causative agent, RVF virus (RVFV), is primarily transmitted through mosquito bites, with transmission also occurring by exposure to infectious aerosols and direct contact with infected body fluids such as blood. Presently, there are no licensed vaccines or medicines to prevent or treat severe RVFV infection in humans. Favipiravir (T-705) is a novel compound licensed for the treatment of influenza in Japan and presently in Phase III clinical trials in the US, which has demonstrated favorable activity against an attenuated strain …