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Full-Text Articles in Veterinary Medicine
The Role Of Bone Marrow In Siv Pathogenesis Using The Rhesus Macaque Model, Amy F. Gill
The Role Of Bone Marrow In Siv Pathogenesis Using The Rhesus Macaque Model, Amy F. Gill
LSU Doctoral Dissertations
CD4+ memory T cells are depleted in mucosal tissues post human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection without restoration to pre-infection levels during progressive course of disease. Bone marrow (BM) as a hematopoietic organ has been investigated for hematologic and morphologic changes during HIV infection. However, BM as a primary lymphoid tissue during HIV infection has been poorly characterized. We proposed BM was also a site of CD4+ T cell depletion driven by increased apoptosis during progressive HIV disease. We chose to investigate bone marrow changes using the premier non-human primate Rhesus macaque SIV model for the …