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Full-Text Articles in Veterinary Medicine
Genetics Of Herpes Simplex Virus Type-1 Tegument Proteins Involved In Virion Morphogenesis And Egress, Preston A. Fulmer
Genetics Of Herpes Simplex Virus Type-1 Tegument Proteins Involved In Virion Morphogenesis And Egress, Preston A. Fulmer
LSU Doctoral Dissertations
Herpes simplex virus type-1 (HSV-1) morphogenesis occurs in multiple stages within infected cells. Initially, the virion capsid assembles within the nucleus and buds through the nuclear membrane into the cytoplasm. Within the cytoplasm, additional tegument proteins attach to the capsid and the fully tegumented capsids bud into trans-Golgi network (TGN) derived vesicles. Enveloped virions are ultimately secreted to extracellular spaces. The process by which the cytoplasmic capsids bud into TGN-derived vesicles is not well understood. The prevalent model calls for specific interactions among viral tegument proteins and membrane proteins and glycoproteins embedded within TGN membranes. To further investigate the roles …