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Carprofen Compromises The Integrity And Barrier Function Of The Colonic Mucosa Of The Dog, Catherine Alix Briere
Carprofen Compromises The Integrity And Barrier Function Of The Colonic Mucosa Of The Dog, Catherine Alix Briere
LSU Master's Theses
Effects of carprofen on colon of dog have not been investigated. Objectives 1) Measure conductance and permeability to mannitol of transverse, proximal descending and distal descending colonic mucosa of dog. 2) Measure conductance and permeability to mannitol of colonic mucosa of dog in presence of carprofen. Design In vitro experimental - nested, randomized block design Animals Colonic mucosa from 6 (objective 1) and 7 (objective 2) mature mixed-breed dogs. Methods Objective 1) Control - Three sections of mucosa from each region of colon were mounted in Ussing chamber units. Conductance was calculated every 15 min for 240 min. Flux of …