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Optimal Age At Fostering For The Derivation Of Helicobacter Hepaticus-Free Mice, Kem Boullion Singletary

LSU Master's Theses

Helicobacter hepaticus is well established as an unwanted variable in laboratory rodent colonies. Historically, caesarean section and embryo transfer have been used to derive Helicobacter-free mouse colonies. Neonatal transfer of newborn mice onto Helicobacter-free foster dams was recently reported as an alternative method of deriving Helicobacter-free mice, but until now, the age by which pups must be fostered to remain Helicobacter-free was unknown. The purpose of this study was to determine the age by which mouse pups must be fostered to remain H. hepaticus-free. Beginning on the day of birth, 20 C57BL/6 mice were fostered from H. hepaticus-positive parents onto …