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Development Of The Neonatal Rat As A Model For Sudden Infant Death Syndrome: Cardiorespiratory Effects Of Ethanol, Rhett Whitman Stout
Development Of The Neonatal Rat As A Model For Sudden Infant Death Syndrome: Cardiorespiratory Effects Of Ethanol, Rhett Whitman Stout
LSU Doctoral Dissertations
The current pathogenesis of Sudden Infant Death Syndrome (SIDS) is unknown. Elevated endogenous ethanol production by gastrointestinal yeast has been proposed as a possible mechanism for SIDS. To investigate the role of ethanol in SIDS, three studies were undertaken. In the first study, transcutaneous blood gas technology was evaluated for repeated monitoring of arterial blood gases. The second study identified the cardiorespiratory responses to inhaled CO2 challenge in juvenile rats, to determine the age corresponding to the age range of peak incidence of SIDS in human infants. Finally, utilizing the optimized juvenile rat model, the cardiorespiratory responses to ethanol and …