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Chondrocyte Death In Canine Osteochondral Explants Exposed To 0.5 Percent Bupivacaine, Geoffrey Stuart Hennig
Chondrocyte Death In Canine Osteochondral Explants Exposed To 0.5 Percent Bupivacaine, Geoffrey Stuart Hennig
LSU Master's Theses
Objective: Our in vitro study evaluated chondrocyte death in canine articular cartilage exposed to 0.5% bupivacaine without (B) and with methylparaben (BP) and compared the viability with intact (SI) and mechanically debrided surfaces (SR). We hypothesized that B or BP would cause chondrocyte death in vitro in a time dependent manner and that chondrocyte death would be increased in SI osteochondral cores compared to SR. Materials and Methods: Intact cartilage cores with underlying subchondral bone were collected aseptically from both humeral heads of 16 fresh canine cadavers. Joints from each dog were randomly assigned to SI or SR. Ten osteochondral …