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Full-Text Articles in Veterinary Medicine
Brucella Melitensis: The Evaluation Of A Putative Hemagglutinin Gene's Effect On Virulence In The Caprine Model, Quinesha Laticia Perry
Brucella Melitensis: The Evaluation Of A Putative Hemagglutinin Gene's Effect On Virulence In The Caprine Model, Quinesha Laticia Perry
LSU Doctoral Dissertations
Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortions in goats and sheep and Malta fever in humans. The zoonotic disease brucellosis causes severe economic losses in the Mediterranean region and parts of Africa, Asia, and Latin America. With the completion of the genomic sequences of B. abortus 2308 and B. melitensis 16M, no classical virulence factors were found; and the chromosomes were virtually identical. However, in B. melitensis, a putative hemagglutinin gene was identified which is absent in B. abortus. The possibility of the hemagglutinin gene being a potential virulence factor was evaluated via gene replacement/deletion in …
Pathogenic Mechanisms Of Photobacterium Damselae Subspecies Piscicida In Hybrid Striped Bass, Ahmad A. Elkamel
Pathogenic Mechanisms Of Photobacterium Damselae Subspecies Piscicida In Hybrid Striped Bass, Ahmad A. Elkamel
LSU Doctoral Dissertations
Photobacterium damselae subspecies piscicida, previously known as Pasteurella piscicida, is an important pathogen of hybrid striped bass and many fish species cultured in brackish water in the United States, Japan, Europe, and the Mediterranean. The purpose of this study is to investigate virulence mechanisms that contribute to the pathogenesis of this organism. The ability of P. damselae to survive/replicate within hybrid striped bass macrophages was evaluated with an in vitro killing assay. Results indicated that the numbers of bacteria recovered from macrophages at 3, 6, 12, and 18 hours of incubation increased significantly over time. In contrast, the numbers of …