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Full-Text Articles in Veterinary Medicine
Development Of Mouse Models For The Study Of Zika Virus Pathogenesis And Antibody Response, Anna Beatriz Kawiecki
Development Of Mouse Models For The Study Of Zika Virus Pathogenesis And Antibody Response, Anna Beatriz Kawiecki
LSU Master's Theses
After the emergence of Zika virus (ZIKV) in the Americas in 2015, ZIKV infection was associated for the first time since its discovery with severe symptoms in both adults and congenital cases, including neurological, ocular, and developmental manifestations. Previous ZIKV circulation in Africa and Southeast Asia has been characterized by mild symptoms and small-scale case-counts. It is unclear whether the unprecedented size and severity of the ZIKV outbreak in the Americas are the consequence of a change in the virus, different background flaviviral immunity in the population, or a reporting issue. In addition, ZIKV has been shown to be transmitted …
Arbovirus Phenotype Alters Transmission Potential, Rebecca C. Christofferson
Arbovirus Phenotype Alters Transmission Potential, Rebecca C. Christofferson
LSU Doctoral Dissertations
Extrinsic and environmental factors are known to affect the transmission of arthropod-borne viruses (arboviruses), including variations in the arthropod vector populations. Differences among these factors have been associated with differential transmission and are sometimes used to control the spread of an arbovirus through a vertebrate population in an effort to prevent or disrupt an outbreak. However, diversity in intrinsic viral populations, such as genetic and phenotypic variability, is not often accounted for when considering alterations in transmission. Presented in this dissertation are four experimental studies that explore the contribution of viral intrinsic factors, especially phenotypic variability, to the transmission potential …