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Articles 1 - 8 of 8
Full-Text Articles in Veterinary Medicine
Influence Of Aedes Aegypti Saliva On The Vertebrate Host Response To Dengue Virus, Michael Kevin Mccracken
Influence Of Aedes Aegypti Saliva On The Vertebrate Host Response To Dengue Virus, Michael Kevin Mccracken
LSU Doctoral Dissertations
Dengue virus (DENV) is maintained in a primarily anthroponotic cycle between humans and the mosquito, Aedes aegypti. Investigations into DENV infection of the vertebrate host generally do not account for the contribution of vector saliva, an inherent part of the mosquito-borne viral inoculum. Feeding by mosquitoes on vertebrate hosts is initiated by probing, which results in physical damage to the skin and vasculature, and the simultaneous introduction of DENV and saliva into the skin. Saliva contains many individual proteins with the potential to modulate host hemostasis and immune responses, thereby facilitating blood feeding and virus transmission. As exogenous antigens, both …
The Role Of Viral Glycoproteins And Tegument Proteins In Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment, Dmitry Vladimirovich Chouljenko
The Role Of Viral Glycoproteins And Tegument Proteins In Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment, Dmitry Vladimirovich Chouljenko
LSU Doctoral Dissertations
Herpes simplex virus type 1 (HSV-1) is a ubiquitous neurotropic alphaherpesvirus transmitted by contact with mucocutaneous surfaces of infected individuals. HSV-1 enters the host by fusion of the viral envelope with the host cell plasma membrane, followed by translocation of the viral capsids to the nucleus where viral DNA is injected into the host cell nucleus to initiate viral replication. To generate infectious virions, newly assembled capsids travel to the cytoplasm and undergo a process called secondary envelopment by budding into cytoplasmic vesicles derived from the trans-Golgi network. Cytoplasmic envelopment is a complex process involving interactions between a multitude of …
Comparison Of Immune Responses During Gastrointestinal Helminth Self-Cure Expulsion Between Resistant Gulf Coast Native And Susceptible Suffolk Sheep, Javier Jesus Garza
Comparison Of Immune Responses During Gastrointestinal Helminth Self-Cure Expulsion Between Resistant Gulf Coast Native And Susceptible Suffolk Sheep, Javier Jesus Garza
LSU Doctoral Dissertations
The immune response to the self-cure phenomenon seen during gastrointestinal nematode (GIN) parasitism of small ruminants was compared between sheep breeds that are resistant or susceptible to Haemonchus contortus infection. Fifty-four Gulf Coast Native (resistant) and Suffolk (susceptible) lambs were allowed to acquire a natural GIN infection on pasture and were then randomly allocated into 4 groups. After being moved to parasite free housing for 2 months, lambs were given a challenge infection of 20,000 H. contortus L3. Fecal egg counts (FEC) were monitored throughout the study and animals were necropsied at 0, 1, 3, and 7 days post infection …
Autologous Adipose Derived Adult Multipotent Stromal Cells Alter The Porcine Systemic Immune And Bone Biomarkers Response To Cancellous Bone Xenografts, Jonathan Francis Bova
Autologous Adipose Derived Adult Multipotent Stromal Cells Alter The Porcine Systemic Immune And Bone Biomarkers Response To Cancellous Bone Xenografts, Jonathan Francis Bova
LSU Master's Theses
The use of a porcine model in assessing bone grafts in vivo is common when a large animal model is necessary. In this thesis we aimed to improve the porcine model of facial reconstruction through the use of a local anesthesia and novel methods of assessing the immune response to and bone forming ability of adult adipose derived mesenchymal stromal cells (ASC). The goals of the research were: 1) evaluate the effect of a bupivacaine mandibular nerve block on blood pressure (BP) and heart rate (HR) in response to surgical stimulation and the need for systemic analgesics postoperatively, 2) quantify …
Outer Surface Lipoprotein Layer Homeostasis And Gene Regulation In Borrelia Burgdorferi, Poonam Dadhwal
Outer Surface Lipoprotein Layer Homeostasis And Gene Regulation In Borrelia Burgdorferi, Poonam Dadhwal
LSU Doctoral Dissertations
The outer surface lipoprotein (osp) layer forms an interface between the internal and the external environment of the Lyme disease spirochete, Borrelia burgdorferi. The homeostatic maintenance of the osp layer effectuates adaptation of B. burgdorferi as it gets transmitted from the tick vector to a mammalian host and vice-versa. However, the regulation of the outer surface lipoproteins (osps) is still a conundrum for borrelia scientists. Part of this dissertation inquires about the homeostatic maintenance of the osp layer. We found that the deletion of the dominantly expressed tick phase osp, OspA, induces expression of two other osps. OspD, and BBJ41. …
Genetics And Functions Of Herpes Simplex Virus Type-1 Membrane Proteins Ul20/Gk In Virion Envelopment And Entry, Anu Susan Charles
Genetics And Functions Of Herpes Simplex Virus Type-1 Membrane Proteins Ul20/Gk In Virion Envelopment And Entry, Anu Susan Charles
LSU Doctoral Dissertations
The envelopment and egress of the Herpes Simplex Virus is an important event in the life cycle of the virus. The important membrane proteins required for the envelopment and egress of the virus are glycoproteins gM, gK, gE and non-glycosylated membrane proteins UL20p and UL11. Among them one of the most critical protein is the UL20 protein which has four transmembrane domains with amino and carboxyl termini are predicted to lie within the cytoplasmic side of cellular membranes. Studies done in our laboratory have shown that deletion of UL20 or other lethal mutations have an adverse effect on envelopment and …
North American Lyme Borreliae: New Distributions And An Insight Into Borrelia Bissettii Infection, Immune Response And Transmission In A Murine Model, Brian Francis Leydet Jr
North American Lyme Borreliae: New Distributions And An Insight Into Borrelia Bissettii Infection, Immune Response And Transmission In A Murine Model, Brian Francis Leydet Jr
LSU Doctoral Dissertations
Lyme borreliosis is an emergent threat to human health. It is estimated that 300,000 cases of Lyme disease are diagnosed annually in the United States. In recent years, non-traditional areas are starting to report more and more cases. While much research has gone into the tick and bacteria responsible for the disease, frequently new Borrelia species are being described and implicated in human illness. These species often go unstudied, and their threat to human health is not known. In the hopes of closing knowledge gaps on Lyme borreliosis in the US, we surveyed a non-endemic state, Louisiana, for Lyme Borrelia …
Mechanisms Of Innate Immunity In Polymicrobial Sepsis, Liliang Jin
Mechanisms Of Innate Immunity In Polymicrobial Sepsis, Liliang Jin
LSU Doctoral Dissertations
Severe bacterial sepsis leads to a pro-inflammatory condition that can manifest as septic shock, multiple organ failure, and death. Neutrophils are critical for the rapid elimination of bacteria, however, the role of neutrophil chemoattractant CXCL1, pattern recognition receptors (PRRs)- NLR protein 3 (NLRP3) and alcohol in bacterial clearance during sepsis remains elusive. We demonstrate that CXCL1 plays a pivotal role in mediating host defense to polymicrobial sepsis following cecal ligation and puncture (CLP) in gene-deficient mice. CXCL1 appears to be essential for restricting bacterial outgrowth and preventing multiple organ failure and death in mice. Moreover, CXCL1 is essential for neutrophil …