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Full-Text Articles in Veterinary Medicine
Cytokine Profiles Following Mycoplasma Hyopneumoniae And Prrsv Co-Infection In Pigs, Roongroje Thanawongnuwech, Eileen L. Thacker
Cytokine Profiles Following Mycoplasma Hyopneumoniae And Prrsv Co-Infection In Pigs, Roongroje Thanawongnuwech, Eileen L. Thacker
The Thai Journal of Veterinary Medicine
Bronchoalveolar cells collected by lung lavage 28 days post infection (DPI) of negative controls, Mycoplasma hyopneumoniae (M. hyo)-infected, Porcine Respiratory and Reproductive Syndrome virus (PRRSV)-infected and dual-infected pigs, were evaluated for various cytokine mRNA (IL1α, IL1β, IL6, IL8, IL10, IL12, and TNFα). Semiquantitative RT-PCR revealed that IL1β, IL6, IL10 and the IL12 mRNA expression was significantly increased in dual-infected pigs, compared with the negative controls. PRRSV-infected pigs had significantly increased levels of IL10 and IL12 mRNA. The increased IL10 gene expression that was observed in the dual infected pigs may play a role in the potentiation of PRRSV-induced pneumonia by …
The Role Of Cytokines In Bovine Mastitis, Kittisak Ajariyakhajorn
The Role Of Cytokines In Bovine Mastitis, Kittisak Ajariyakhajorn
The Thai Journal of Veterinary Medicine
Cytokines are protein mediators produced by the immune and nonimmune cells that are involved in the regulation of inflammation and immune responses. The availability of several recombinant bovine cytokines have led to the investigation of the potential of cytokines as prophylactic or therapeutic strategies in the control of bovine mastitis, the most expensive disease affecting the dairy industry. The main goals of cytokine therapy are to enhance the immune response in the mammary gland against pathogenic bacteria, to increase the efficacy of antibiotic treatment, and to enhance the specific immunity of mastitis vaccines. Important cytokines used in mastitis studies are …