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Full-Text Articles in Translational Medical Research
West Nile Virus And Pattern Recognition Receptors, Jordan Boswell, Verma Saguna, Phd, Chih-Yun Lai
West Nile Virus And Pattern Recognition Receptors, Jordan Boswell, Verma Saguna, Phd, Chih-Yun Lai
Journal of Health Disparities Research and Practice
West Nile Virus (WNV), RNA virus is a member of the flaviviridae family that causes flu like symptoms in infected individuals, however in 1-2% cases, it causes severe neurological diseases such as encephalitis. There is no antiviral or vaccine approved so far to prevent WNV disease, therefore research to understand immune pathology is very important.
Pattern Recognition Receptors (PRR) are proteins that are expressed by cells to detect virus infection and play an important role in the innate immune system. When a PRR such as Toll-Like Receptors (TLR) and Nod-Like Receptors (NLR) detects a replicating virus, signals are sent out …