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Translational Medical Research Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
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- Blood pressure control (1)
- CSAR (1)
- Cancer (1)
- Cancer Progression (1)
- Cardiac Sympathetic Afferent Reflex (1)
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- Extracellular Matrix (1)
- Extracellular nucleotides (1)
- Glucose homeostasis (1)
- Glucose tolerance (1)
- Inflammation (1)
- Inflammation-induced insulin resistance (1)
- Insulin resistance (1)
- Kidney Injury Molecule-1 (KIM-1) (1)
- Nucleotide signaling (1)
- Orthotopic (1)
- P2Y2 Receptor (1)
- PVN (1)
- Paraventricular Nucleus (1)
- RNA-seq (1)
- Renal Cell Carcinoma (RCC) (1)
- Sex hormones (1)
- Subcutaneous (1)
- Tumour Microenvironment (1)
Articles 1 - 3 of 3
Full-Text Articles in Translational Medical Research
Modulation Of Glucose Homeostasis By Nucleotide P2y2 Receptor And Biological Sex, Hailee Anne Marino
Modulation Of Glucose Homeostasis By Nucleotide P2y2 Receptor And Biological Sex, Hailee Anne Marino
MSU Graduate Theses
Recent insights into the pathological role of Nucleotide P2Y2 receptor suggest P2Y2R involvement in high fat diet-induced obesity and potentiates insulin resistance. However, these recent insights do not demonstrate how P2Y2R modulates glucose homeostasis under physiological conditions. Further, it remains unknown how sex biological factors influence P2Y2R receptor signaling in the regulation of glucose homeostasis. The research objective for the present study is to elucidate the novel roles of P2Y2 in fasting blood glucose and glucose tolerance (basal insulin sensitivity) under resting conditions in males and females. We expected that under physiological …
Differential Effects Of Kim-1 In Subcutaneous And Orthotopic Renca Models Of Kidney Cancer, Demitra M. Yotis Dy
Differential Effects Of Kim-1 In Subcutaneous And Orthotopic Renca Models Of Kidney Cancer, Demitra M. Yotis Dy
Electronic Thesis and Dissertation Repository
Renal Cell Carcinoma (RCC) is the most common and fatal type of kidney cancer. Over 30% of patients that are diagnosed with RCC exhibit metastases. Almost 88% of patients with distant metastases succumb to the disease within 5 years of diagnosis. Kidney Injury Molecule-1 (KIM-1) is a cell surface glycoprotein that is not expressed in a healthy kidney but becomes highly expressed on proximal tubular epithelial cells (PTECs) following injury. Data from the Cancer Genome Atlas (TCGA) reveals that >90% of RCC tumours express KIM-1 mRNA and that higher expression levels correlate with increased overall survival rates of patients. The …
Pvn Activity In Cardiac Sympathetic Afferent Reflex (Csar) Control And Cardiovascular Function, Shane H. Boomer
Pvn Activity In Cardiac Sympathetic Afferent Reflex (Csar) Control And Cardiovascular Function, Shane H. Boomer
Honors Thesis
Regulation of blood pressure is essential in bodily health. Hypertension and hypotension can be associated with varying diseases that could potentiate further disease. From this, understanding the mechanisms that regulate blood pressure is important within medicine. In my study, I will be focusing on a cardiovascular reflex that is less well understood, the cardiac sympathetic afferent reflex (CSAR). In particular, this work will examine sex differences in this reflex in overall function and in the involvement of an area of the brain called the paraventricular nucleus (PVN). We will test the hypothesis that there will be a significant difference between …