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Full-Text Articles in Sports Sciences

Examination Of Physiological And Perceptual Responses During Sustained, Isometric, Fatiguing, Handgrip Exercise Anchored To Ratings Of Perceived Exertion, Minyoung Kwak Jan 2023

Examination Of Physiological And Perceptual Responses During Sustained, Isometric, Fatiguing, Handgrip Exercise Anchored To Ratings Of Perceived Exertion, Minyoung Kwak

Theses and Dissertations--Kinesiology and Health Promotion

The purposes of this study were to: 1) Examine the patterns of force responses relative to critical force (CF) during submaximal, fatiguing, isometric handgrip exercise anchored to different rating of perceived exertion (RPE) levels (RPE=3, 5, and 7); 2) assess the loss of force during the task and the level of performance fatigability after each RPE hold; 3) examine the time course of changes and patterns of neuromuscular [electromyography (EMG) amplitude (AMP), mean power frequency (MPF), mechanomyography (MMG) AMP and MPF, and neuromuscular efficiency (NME) (i.e. force/EMG AMP)] and muscle oxygen saturation (% SmO2) responses during each RPE …


Neurophysiological And Psychological Characteristics Of Individuals With History Of Lateral Ankle Sprain, Katherine Bain Jan 2022

Neurophysiological And Psychological Characteristics Of Individuals With History Of Lateral Ankle Sprain, Katherine Bain

Theses and Dissertations--Rehabilitation Sciences

Lateral ankle sprain (LAS) is among the most common lower limb musculoskeletal injuries impacting both the general and sport populations. Even more problematic is that approximately 70% of individuals who sustain an LAS develop residual deficits. Of that subgroup, roughly 40% develop chronic ankle instability (CAI). Chronic ankle instability is a clinical diagnosis defined by the presence of ongoing impairments following the initial LAS which may include perceived instability, pain, mechanical instability, and episodes of giving way during physical activity. Not all who sustain multiple ankle sprains or experience residual deficits fit the clinical diagnosis criteria for CAI; yet may …


The Utilization Of Physical Literacy To Understand Physical Activity In Individuals With A History Of Anterior Cruciate Ligament Reconstruction, Rachel Renee Kleis Jan 2022

The Utilization Of Physical Literacy To Understand Physical Activity In Individuals With A History Of Anterior Cruciate Ligament Reconstruction, Rachel Renee Kleis

Theses and Dissertations--Rehabilitation Sciences

Injury to the anterior cruciate ligament (ACL) is common in physically active populations. Anterior cruciate ligament reconstruction (ACLR) is commonly performed after injury in order to restore joint stability and knee function and return patients to desired levels of physical activity. However, not everyone will return to their pre-injury levels of sport after surgery and recent evidence reveals that individuals with a history of ACLR are less likely to meet the recommended physical activity guidelines. Specifically, previous literature has reported that individuals with a history of ACLR take fewer daily steps and participate in less moderate-to-vigorous physical activity compared to …


The Correlation Between Acl Injury & Concussion, Brandon Michael Phillips Jan 2022

The Correlation Between Acl Injury & Concussion, Brandon Michael Phillips

Theses and Dissertations--Kinesiology and Health Promotion

Concussion (also known as mild traumatic brain injury) is a neurological injury that occurs after a blow to the head or neck area and can have affects to movement based on the severity of the injury. Mild traumatic brain injury has possible linkage to an increased risk of anterior cruciate ligament (ACL) injury. The purpose of this thesis was to assess the impact of prior concussion on lower extremity mechanics that are associated with risk of ACL injury. A total of 11 individuals with prior history of concussion and 11 healthy individuals without prior history of concussion (56.5 months since …


Mechanical Deviations And Verbal-Cue Altered Gait In The Femoroacetabular Impingement Syndrome Population, Walter Menke Jan 2021

Mechanical Deviations And Verbal-Cue Altered Gait In The Femoroacetabular Impingement Syndrome Population, Walter Menke

Theses and Dissertations--Kinesiology and Health Promotion

Femoroacetabular impingement syndrome (FAIS) is an abnormal physical hip morphology that causes functional changes and pain during gait. Mechanical gait differences in this population require further biomechanical investigation to elucidate characteristics unique to this group. Fixed speed gait trials were performed on force plates and analyzed in addition to isokinetic strength testing to find a multitude of biomechanical variables including joint moment, joint power, joint work, and peak joint angle. This work has discovered evidence of muscular deficits at the hip, specifically hip extension, as well as knee joint power contributions to gait when compared to controls. These findings suggest …


Examination Of Sex- And Limb-Specific Fatigue During Unilateral, Isometric Forearm Exercise, Caleb Christian Voskuil Jan 2021

Examination Of Sex- And Limb-Specific Fatigue During Unilateral, Isometric Forearm Exercise, Caleb Christian Voskuil

Theses and Dissertations--Kinesiology and Health Promotion

The purpose of this study was to examine the effects of unilateral, isometric handgrip holds to failure for the dominant (Dm) and non-dominant (NDm) limb on ipsilateral ([IPS] exercised side) and contralateral ([CON] non-exercised side) performance fatigability. Twenty individuals participated in this study (Men [n =10]; Women [n = 10; Composite Demographics: Age: 22.2 years; Height: 174.4 cm; Body Mass: 75.0 kg) and completed three visits. Two, 6 s maximal voluntary isometric contractions (MVICs) for the Dm and NDm limb were performed during visit 1, followed by a familiarization of the fatigue test. Visits 2 and 3 included an isometric, …


Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin Jan 2021

Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin

Theses and Dissertations--Toxicology and Cancer Biology

Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological activity rather than arbitrary limits of detection. This dissertation looks to address this by suggesting a system of calculated Effective Plasma Concentrations by which a …


Effect Of Blood Flow Restriction Training On Functional And Self-Reported Outcomes In Female Runners With Patellofemoral Pain, Lauren Nicole Erickson Jan 2021

Effect Of Blood Flow Restriction Training On Functional And Self-Reported Outcomes In Female Runners With Patellofemoral Pain, Lauren Nicole Erickson

Theses and Dissertations--Rehabilitation Sciences

Background: Patellofemoral pain (PFP) is the leading cause of lower extremity injury in female runners, significantly limiting running ability and becoming chronic in nearly 50% of the cases. This condition, which presents as pain around (peripatellar) or behind (retropatellar) the patella, is associated with significant weakness of the quadriceps and gluteal musculature, as well as altered movements mechanics. The challenge for clinicians is designing an effective treatment program to reduce pain and improve function without causing symptoms to flare. Blood flow restriction training (BFRT) is a relatively new training method within rehabilitation that involves placing a pressurized cuff to the …


Epidemiology Of Upper Extremity Injuries In High School Sports, Autumn Ruthe Whitson Jan 2021

Epidemiology Of Upper Extremity Injuries In High School Sports, Autumn Ruthe Whitson

Theses and Dissertations--Rehabilitation Sciences

Participation in high school sports has seen a steady increase over the past four decades. With nearly eight million student-athletes participating, careful monitoring of injuries related to their participation is imperative. Injury surveillance efforts through national databases have produced a multitude of studies detailing injuries that occur in specific sports, specific body parts, or particular diagnoses. The lower extremity tends to be injured more frequently than the upper extremity resulting in various comprehensive analyses on that particular body area. Currently, there are no comprehensive reports on the epidemiology of injury to the upper extremity in student-athletes participating in high school …


Development Of A Field Expedient Screening Tool For The Coach To Identify Musculoskeletal Risk Factors In Baseball Players, Kyle Andrew Matsel Jan 2021

Development Of A Field Expedient Screening Tool For The Coach To Identify Musculoskeletal Risk Factors In Baseball Players, Kyle Andrew Matsel

Theses and Dissertations--Rehabilitation Sciences

Identification of musculoskeletal (MSK) injury risk factors in baseball players can be challenging particularly for youth and high school coaches. Many baseball coaches lack a sports medicine and/or strength and conditioning staff to assist with injury prevention initiatives. Given the extensive responsibilities in managing the team and preparing the players for athletic competition, little time remains to focus on injury prevention and arm care programs. Furthermore, assessment, diagnosis, and management of MSK impairments is outside the scope of practice and expertise of baseball coaches. However, educating and empowering the coach to efficiently screen their players for potentially injury producing MSK …


High Performance: Exploratory Study Into The High Performance Model And Qualitative Secondary Analysis Of Elite Sport Management In The United States, Jon Gregory Hill Jan 2021

High Performance: Exploratory Study Into The High Performance Model And Qualitative Secondary Analysis Of Elite Sport Management In The United States, Jon Gregory Hill

Theses and Dissertations--Education Sciences

This dissertation examines the area of high performance in elite sport through high performance professionals’ perspectives in the United States Olympic and Paralympic National Governing Bodies. The study’s purpose was to establish a shared meaning of the high performance sport management model by its elements in the athletic arena. Interviews with 16 high performance directors and managers were conducted to establish definitions, backgrounds, and anatomy of high performance in sport: high performance, high performance sport, high performance management, high performance model.

A qualitative secondary analysis was conducted to examine the high performance model in the U.S. and explore the job …


Comparison Of The Times To Exhaustion, Physiological, Perceptual, And Neuromusuclar Responses During Constant Heart Rate, Constant Vo2, And Constant Power Exercise, Pasquale Jiovanni Succi Jan 2021

Comparison Of The Times To Exhaustion, Physiological, Perceptual, And Neuromusuclar Responses During Constant Heart Rate, Constant Vo2, And Constant Power Exercise, Pasquale Jiovanni Succi

Theses and Dissertations--Kinesiology and Health Promotion

The purposes of this study were to: 1) Determine if there are differences in the sustainability of exercise when anchored at critical heart rate (CHR), the VO2 associated with CHR (VO2CHR), or the power output associated with CHR (PCHR); 2) examine the patterns of responses in power output, metabolic (heart rate [HR], VO2, respiration rate [RR]), neuromuscular (electromyographic [EMG] amplitude [AMP], mean power frequency [MPF], mechanomyographic [MMG] AMP and MPF, perceptual (rating of perceived exertion [RPE]), and muscle oxygenation responses (%SmO2) during exercise anchored by HR, VO2, and power output; and …


Examination Of Sex- And Intensity-Specific Fatigue During Bilateral Leg Extension Exercise, Taylor Kayln Dinyer Jan 2021

Examination Of Sex- And Intensity-Specific Fatigue During Bilateral Leg Extension Exercise, Taylor Kayln Dinyer

Theses and Dissertations--Kinesiology and Health Promotion

The purposes of this study were to: 1) examine sex-related differences in the performance of repetitions to failure below (CL-10%, CL-20%) and above (50%, 60%, 70%, and 80% 1RM) the critical load (CL) to make inferences regarding the mechanisms responsible for variability in the performance of repetitions to failure at varying loads; 2) examine the time course of neuromuscular and muscle oxygen saturation responses during the performance of repetitions to failure below and above the CL; 3) to make inferences regarding motor unit activation strategies used to maintain force during the completion of repetitions below and …


Methodological Considerations For The Determination Of The Critical Resistance For The Deadlift, Alexander C. Moss Jan 2020

Methodological Considerations For The Determination Of The Critical Resistance For The Deadlift, Alexander C. Moss

Theses and Dissertations--Kinesiology and Health Promotion

This study determined if plate movement during conventional deadlifting affects critical resistance (CR) estimates derived from the linear work limit (Wlim) versus repetitions relationship. Eleven subjects completed 1-repetition maximum (1RM) deadlift testing followed by 8 visits, to determine the number of repetitions to failure at 50%, 60%, 70%, and 80% 1RM for both reset (RS) and touch-and-go (TG) methods, respectively. The CR was calculated as slope of the line of total work completed (repetitions × load [in kilograms]) versus total repetitions for each of four intensities (50-80% 1RM). The number of repetitions to failure were determined at CR …


Effects Of Relative Inertial Load On Performance Measures And Quadriceps Electromyography During Flywheel Resistance Training Squats, Jason Todd Brantley Jr. Jan 2020

Effects Of Relative Inertial Load On Performance Measures And Quadriceps Electromyography During Flywheel Resistance Training Squats, Jason Todd Brantley Jr.

Theses and Dissertations--Kinesiology and Health Promotion

Flywheel resistance training (FRT) has become an increasingly popular modality for exercising due to its unique application of providing external resistance. Little is known about how changes in relative inertial loads affects performance and electromyography (EMG) activity. The purpose of this study was to examine how performance metrics and quadriceps EMG activity are affected by relative inertial load during FRT-based squats. Fifteen resistance trained individuals completed five sets of five repetitions of squats with varying relative inertial loads in random order. Peak Eccentric Power (PEP), Peak Concentric Power (PCP), average force, total work, and repetition time were measured. Surface level …


Application Of High Performance Training Strategies To Enhance Occupational Readiness In Law Enforcement Cadets, Gabriel Jose Martinez Jan 2020

Application Of High Performance Training Strategies To Enhance Occupational Readiness In Law Enforcement Cadets, Gabriel Jose Martinez

Theses and Dissertations--Kinesiology and Health Promotion

Law enforcement requires cadets to achieve a requisite level of physical fitness to prepare for occupational demands. However, there is limited research on the effectiveness of academy exercise programs to optimize physical fitness and occupational physical ability through high performance training strategies more typically utilized in elite athletic populations. Furthermore, there is a paucity of research identifying physical fitness correlates of occupational performance. Collectively, this information will provide academies and practitioners with critical information to develop evidence-based training programs. Therefore, the purposes of this study were to: Aim 1) Examine the effectiveness of integrating autoregulatory progressive resistance exercise (APRE) and …


Effects Of Load Carriage On Shoulder Neuromuscular Functions And Recovery, Muataz R. Almaddah Jan 2020

Effects Of Load Carriage On Shoulder Neuromuscular Functions And Recovery, Muataz R. Almaddah

Theses and Dissertations--Rehabilitation Sciences

Load carriage is a primary source for injury occurrence among military personnel and recreational hikers affecting all body areas. The shoulder ranks as the second or third most common site of injuries among military personnel. Many studies report that elevations in self-reported fatigue, soreness, and discomfort in the shoulders accompany the load carriage. Almost 50% of military personnel experienced a load carriage injury during the first episode of training, and 75% of those injured suffered a second injury during their career. The goal of this research project is to investigate the components associated with load carriage shoulder symptoms to determine …


Influences Of Functional And Psychological Factors On Biomechanics Following An Anterior Cruciate Ligament (Acl) Reconstruction, Chelsey Roe Jan 2020

Influences Of Functional And Psychological Factors On Biomechanics Following An Anterior Cruciate Ligament (Acl) Reconstruction, Chelsey Roe

Theses and Dissertations--Rehabilitation Sciences

Objective: The aims of this research were to identify gaps in the literature related to return to sport (RTS) test batteries following primary anterior cruciate ligament reconstruction (ACLR) (Aim 1) and define recovery in athletes from 4-9 months after ACLR across three domains: 1) psychological recovery and biomechanics (Aim 2), 2) rehabilitation quantity and biomechanics (Aim 3), and 3) functional performance and biomechanics (Aim 4). Ultimately, the results of this research would quantify recovery following ACLR in athletes with a desire to RTS and identify objective criteria throughout rehabilitation prior to RTS.

Participants: Twenty-two post-ACLR athletes 17 females, 8 males, …


Effects Of Curcumin And Fenugreek Soluble Fiber Supplements On Submaximal And Maximal Aerobic Performance Indices In Untrained College-Aged Subjects, Jensen Goh Zhong Sheng Jan 2019

Effects Of Curcumin And Fenugreek Soluble Fiber Supplements On Submaximal And Maximal Aerobic Performance Indices In Untrained College-Aged Subjects, Jensen Goh Zhong Sheng

Theses and Dissertations--Kinesiology and Health Promotion

Submaximal exercise performance is, in part, limited by the accumulation of metabolic byproducts and energy system capacities. Curcumin and the combination of curcumin and fenugreek soluble fiber (CurQfen®) have been shown to increase endogenous antioxidants and metabolic byproduct clearance as well as reduce inflammation and lipid peroxidation, and therefore, may enhance submaximal aerobic thresholds. In addition, there is evidence that the galactomannan component of fenugreek, used to enhance bioavailability of curcumin, may also have potential physiological effects related to the up regulation of free fatty acid oxidation Therefore, the purpose of this study was to examine the effects …


Susceptibility To Ankle Sprain Injury Between Dominant And Non-Dominant Leg During Jump Landings, Riley Pashak Jan 2019

Susceptibility To Ankle Sprain Injury Between Dominant And Non-Dominant Leg During Jump Landings, Riley Pashak

Theses and Dissertations--Kinesiology and Health Promotion

Ankle sprains are one of the most common injuries within athletics in the United States with approximately one-million student athletes experiencing ankle sprains each year. Studies argue excessive or rapid ankle inversion occurring from jump landings may cause ankle sprains. Also, the effect of limb dominance on risk of ankle sprain is not well documented.

The aim of this study was to determine if there is an affect of leg dominance on landing mechanism of the ankle joint that predisposes either ankle joint to greater risk of ankle sprain.

Twelve recreationally active subjects were recruited and completed four maximal vertical …


Longitudinal Descriptive Profile Of Collegiate Pitchers Participating In A Summer Baseball League, Isabelle Leslie Gillis Jan 2019

Longitudinal Descriptive Profile Of Collegiate Pitchers Participating In A Summer Baseball League, Isabelle Leslie Gillis

Theses and Dissertations--Kinesiology and Health Promotion

The purpose of this study was to provide a longitudinal profile of pitching performance in a cohort of pitchers over two collegiate seasons and a summer league. Thus, this study utilized a longitudinal design to evaluate the impact of summer league participation on subsequent collegiate regular season pitching performance. Specifically, the performance of a cohort of Division 1 collegiate baseball pitchers during the 2018 Spring collegiate season, 2018 Summer League season, and the 2019 Spring collegiate season was evaluated and stratified by pitcher designation, arm dominance, and academic status. Analyses of variance were used to identify main and interaction effects …


Injury-Related Fear In Patients After Anterior Cruciate Ligament Reconstruction, Shelby Elyse Baez Jan 2019

Injury-Related Fear In Patients After Anterior Cruciate Ligament Reconstruction, Shelby Elyse Baez

Theses and Dissertations--Rehabilitation Sciences

Approximately 200,000 anterior cruciate ligament (ACL) injuries occur each year with about 100,000 of these injuries undergoing reconstruction (ACLR). The impetus of ACLR is to allow previously high functioning, physically active individuals to return to desired levels of sports participation and to engage in recommended levels of physical activity. However, 1 out of 3 patients after ACLR fail to return to competitive levels of sport and meet recommended levels of physical activity. Injury-related fear has been cited as the primary barrier for failure to return to sport. However, the research has been primarily qualitative in nature and limited research has …


Connecting The Pieces: How Low Back Pain Alters Lower Extremity Biomechanics And Shock Attenuation In Active Individuals, Alexa Johnson Jan 2019

Connecting The Pieces: How Low Back Pain Alters Lower Extremity Biomechanics And Shock Attenuation In Active Individuals, Alexa Johnson

Theses and Dissertations--Rehabilitation Sciences

Low back pain in collegiate athletes has been reported at a rate of 37% from a wide array of sports including soccer, volleyball, football, swimming, and baseball. Whereas, in a military population the prevalence of low back pain is 70% higher than the general population. Compensatory movement strategies are often used as an attempt to reduce pain. Though compensatory movement strategies may effectively reduce pain, they are often associated with altered lower extremity loading patterns. Those who suffer from chronic low back pain tend to walk and run slower and with less trunk and pelvis coordination and variability. Individuals with …


The Effect Of Personal Protective Equipment On Firefighter Occupational Performance, Ashley Y. Lesniak Jan 2017

The Effect Of Personal Protective Equipment On Firefighter Occupational Performance, Ashley Y. Lesniak

Theses and Dissertations--Kinesiology and Health Promotion

Firefighting is a strenuous occupation that requires high-intensity work, resulting in prolonged periods of stress and physical exertion. The physical demand of performing firefighting tasks is augmented by the weight of personal protective equipment (PPE) worn (i.e., load carriage: LC) and the use of a self-contained breathing apparatus (SCBA). These factors have been shown to increase metabolic demand at submaximal workloads and decrease maximal aerobic capacity in laboratory settings. However, there is limited research evaluating the effects of these factors on occupational performance. Therefore, the primary purpose of this study was to quantify the detrimental effect of LC only and …


Examination Of Volume And Intensities Of Weekday Practices And Competitive Games In Collegiate Football Players, Tyler Lindon Jan 2017

Examination Of Volume And Intensities Of Weekday Practices And Competitive Games In Collegiate Football Players, Tyler Lindon

Theses and Dissertations--Kinesiology and Health Promotion

The aims of the present study were to characterize the typical volume (total distance) and intensities (high-speed distance > 75% of maximum speed for weekday practices, Monday through Friday and competitive games on Saturday; compare the daily practice volume and intensities to competitive games to determine if the targeted volume and intensities are achieved as part of the periodized strategies using GPS software; and examine the relationship among total distance, high-speed distance in the prediction of player-load . Thirty NCAA Division I Football players (187.9 ± 5.5 cm; 107.4 ± 24.6 kg) were monitored using GPS receivers with integrated accelerometers during …


The Effects Of Golf Stance On The Peak Knee Adduction Moment During The Golf Swing, Quenten L. Hooker Jan 2017

The Effects Of Golf Stance On The Peak Knee Adduction Moment During The Golf Swing, Quenten L. Hooker

Theses and Dissertations--Kinesiology and Health Promotion

INTRODUCTION: The knee joint is one of the most frequently injured structures in the game of golf. The loads experienced by the knee during the golf swing are typically greater than those experienced during walking. In particular, a heightened lead limb peak external knee adduction moment has been linked to the progression of medial compartment knee osteoarthritis (OA). Altering movement patterns is a common strategy that can be used to reduce loading on the knee joint but has received little attention during the golf swing. Also, while such manipulations may be beneficial from an injury prevention perspective, they may have …


Prediction Of Acute And Recurrent Ankle Sprains In Athletes, Ryan S. Mccann Jan 2017

Prediction Of Acute And Recurrent Ankle Sprains In Athletes, Ryan S. Mccann

Theses and Dissertations--Rehabilitation Sciences

Ankle sprains are not only among the most common sport-related injuries, but also associated with a high rate of recurrence. While prevention is a favorable approach to reducing the incidence of index and recurrent ankle sprains, identifying individuals at greater risk may improve allocation of preventative resources. This dissertation aimed to accomplish the following through three aims: 1) determine the ability of baseline clinical tests to predict acute lateral ankle sprain (LAS) in an understudied athletic population, 2) describe the degree of residual impairments and activity limitations in athletes returning to play from a LAS, and 3) determine the ability …


Chronic Ankle Instability And Aging, Kyle B. Kosik Jan 2017

Chronic Ankle Instability And Aging, Kyle B. Kosik

Theses and Dissertations--Rehabilitation Sciences

Lateral ankle sprains are the most common musculoskeletal injury among the general population and U.S. military personnel. Despite the common perception of being a minor injury, at least 1 out of 3 individuals with a previous ankle sprain will develop chronic ankle instability (CAI). This clinical phenomenon creates a significant barrier for patients to return to their prior level of physical function. Specifically, CAI is associated with reductions in physical activity level, leading to decreases in lower health-related quality of life and increase risk of developing of post-traumatic ankle osteoarthritis. Current evidence has largely focused on characterizing the mechanical and …


Methods For Determining Time To Return To Play After Recreational Injury In Field And Court Sport Athletes, Sarah N. Morris Jan 2017

Methods For Determining Time To Return To Play After Recreational Injury In Field And Court Sport Athletes, Sarah N. Morris

Theses and Dissertations--Epidemiology and Biostatistics

An observational study was used to illustrate the application of time to event analysis methods to return to play; a secondary data analysis of athlete injury data from the High School RIOTM Injury Surveillance System (ISS) database was conducted. National Athletic Trainers’ Association (NATA)-certified athletic trainers from approximately 100 high schools in the US enroll their school in the system and complete the online “Exposure Report Form” for reportable injuries each week. New lateral ankle sprains and single-ligament knee injuries experienced by high school athletes during regularly scheduled participation in school-sanctioned sports for seven academic years (2005-2006 through 2011-2012) …


Role Of Skeletal Paracrine Signals In The Proliferation And Chondrogenic Differentiation Of Interzone Cells, Parvathy Thampi Jan 2017

Role Of Skeletal Paracrine Signals In The Proliferation And Chondrogenic Differentiation Of Interzone Cells, Parvathy Thampi

Theses and Dissertations--Veterinary Science

Articular cartilage in mammals has a limited intrinsic capacity to repair structural injuries and defects, a fact that contributes to the chronic and progressive nature of osteoarthritis. Current treatment modalities do not enable articular cartilage to achieve a complete and permanent restoration of normal structure and function with large or partial thickness lesions. In contrast to mammals, Mexican axolotl salamanders (Ambystoma mexicanum) have demonstrated the remarkable ability to spontaneously and completely repair even large joint cartilage lesions, an intrinsic healing process that involves interzone cells in the intraarticular space. Further, when interzone tissue is transplanted into critical sized …