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Full-Text Articles in Sports Sciences
Hindlimb Suspension In Wistar Rats: Sex-Based Differences In Muscle Response, Marie Mortreux, Megan E. Rosa-Caldwell, Ian D. Stiehl, Dong-Min Sung, Nicholas T. Thomas, Christopher S. Fry, Seward B. Rutkove
Hindlimb Suspension In Wistar Rats: Sex-Based Differences In Muscle Response, Marie Mortreux, Megan E. Rosa-Caldwell, Ian D. Stiehl, Dong-Min Sung, Nicholas T. Thomas, Christopher S. Fry, Seward B. Rutkove
Athletic Training and Clinical Nutrition Faculty Publications
Ground-based animal models have been used extensively to understand the effects of microgravity on various physiological systems. Among them, hindlimb suspension (HLS), developed in 1979 in rats, remains the gold-standard and allows researchers to study the consequences of total unloading of the hind limbs while inducing a cephalic fluid shift. While this model has already brought valuable insights to space biology, few studies have directly compared functional decrements in the muscles of males and females during HLS. We exposed 28 adult Wistar rats (14 males and 14 females) to 14 days of HLS or normal loading (NL) to better assess …