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Full-Text Articles in Sports Sciences
Reactive Oxygen Species (Ros) And Antioxidants As Immunomodulators In Exercise: Implications For Heme Oxygenase And Bilirubin, David Travis Thomas, Nicholas R. Delcimmuto, Kyle D. Flack, David E. Stec, Terry D. Hinds Jr.
Reactive Oxygen Species (Ros) And Antioxidants As Immunomodulators In Exercise: Implications For Heme Oxygenase And Bilirubin, David Travis Thomas, Nicholas R. Delcimmuto, Kyle D. Flack, David E. Stec, Terry D. Hinds Jr.
Athletic Training and Clinical Nutrition Faculty Publications
Exercise is commonly prescribed as a lifestyle treatment for chronic metabolic diseases as it functions as an insulin sensitizer, cardio-protectant, and essential lifestyle tool for effective weight maintenance. Exercise boosts the production of reactive oxygen species (ROS) and subsequent transient oxidative damage, which also upregulates counterbalancing endogenous antioxidants to protect from ROS-induced damage and inflammation. Exercise elevates heme oxygenase-1 (HO-1) and biliverdin reductase A (BVRA) expression as built-in protective mechanisms, which produce the most potent antioxidant, bilirubin. Together, these mitigate inflammation and adiposity. Moderately raising plasma bilirubin protects in two ways: (1) via its antioxidant capacity to reduce ROS and …