Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Rehabilitation and Therapy
Combined Unilateral Blockade Of Cholinergic, Peptidergic, And Serotonergic Receptors In The Ventral Respiratory Column Does Not Affect Breathing In Awake Or Sleeping Goats, Clarissa Muere, Suzanne Neumueller, Samantha Olesiak, Justin Robert Miller, Thomas Langer, Matthew Hodges, Lawrence Pan, Hubert Forster
Combined Unilateral Blockade Of Cholinergic, Peptidergic, And Serotonergic Receptors In The Ventral Respiratory Column Does Not Affect Breathing In Awake Or Sleeping Goats, Clarissa Muere, Suzanne Neumueller, Samantha Olesiak, Justin Robert Miller, Thomas Langer, Matthew Hodges, Lawrence Pan, Hubert Forster
Physical Therapy Faculty Research and Publications
Previous work in intact awake and sleeping goats has found that unilateral blockade of excitatory inputs in the ventral respiratory column (VRC) elicits changes in the concentrations of multiple neurochemicals, including serotonin (5-HT), substance P, glycine, and GABA, while increasing or having no effect on breathing. These findings are consistent with the concept of interdependence between neuromodulators, whereby attenuation of one modulator elicits compensatory changes in other modulators to maintain breathing. Because there is a large degree of redundancy and multiplicity of excitatory inputs to the VRC, we herein tested the hypothesis that combined unilateral blockade of muscarinic acetylcholine (mACh), …
Blockade Of Neurokinin-1 Receptors In The Ventral Respiratory Column Does Not Affect Breathing But Alters Neurochemical Release, Clarissa Muere, Suzanne Neumueller, Samantha Olesiak, Justin Miller, Matthew Hodges, Lawrence Pan, Hubert Forster
Blockade Of Neurokinin-1 Receptors In The Ventral Respiratory Column Does Not Affect Breathing But Alters Neurochemical Release, Clarissa Muere, Suzanne Neumueller, Samantha Olesiak, Justin Miller, Matthew Hodges, Lawrence Pan, Hubert Forster
Physical Therapy Faculty Research and Publications
Substance P (SP) and its receptor, neurokinin-1 (NK1R), have been shown to be excitatory modulators of respiratory frequency and to stabilize breathing regularity. Studies in anesthetized mice suggest that tonic activation of NK1Rs is particularly important when other excitatory inputs to the pre-Bötzinger complex in the ventral respiratory column (VRC) are attenuated. Consistent with these findings, muscarinic receptor blockade in the VRC of intact goats elicits an increase in breathing frequency associated with increases in SP and serotonin concentrations, suggesting an involvement of these substances in neuromodulator compensation. To gain insight on the contribution to breathing of endogenous SP and …