Other Public Health Commons^™

Virtual And In Vitro Screening Of Natural Products Identifies Indole And Benzene Derivatives As Inhibitors Of Sars-Cov-2 Main Protease (MPro), Dony Ang, Riley Kendall, Hagop S. Atamian

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The rapid spread of the coronavirus disease 2019 (COVID-19) resulted in serious health, social, and economic consequences. While the development of effective vaccines substantially reduced the severity of symptoms and the associated deaths, we still urgently need effective drugs to further reduce the number of casualties associated with SARS-CoV-2 infections. Machine learning methods both improved and sped up all the different stages of the drug discovery processes by performing complex analyses with enormous datasets. Natural products (NPs) have been used for treating diseases and infections for thousands of years and represent a valuable resource for drug discovery when combined with …

The Effectiveness Of Pay-It-Forward In Addressing Hpv Vaccine Delay And Increasing Uptake Among 15–18-Year-Old Adolescent Girls Compared To User-Paid Vaccination: A Study Protocol For A Two-Arm Randomized Controlled Trial In China, Yifan Li, Chuanyu Qin, Shengyue Qiu, Yu He, Linchuan Pang, Xiaolan Xu, Vivian Wan-Cheong Yim, Shenglan Tang, Heng Du, Wenfeng Gong, Fan Yang, Joseph D. Tucker, Weiming Tang, Yun Wang, Leesa Lin, Mark Jit, Wei Song, Chunrong Li, Jennifer Smith, Jing Li, Dan Wu

Pharmacy Faculty Articles and Research

Background

Human papillomavirus (HPV) vaccination could prevent cervical and other HPV-associated cancers attributable to vaccine-associated HPV types. However, HPV vaccination coverage among women aged 9–18 years old is low in China. Common barriers include poor financial affordability, minimal public engagement, and low confidence in domestically produced HPV vaccines. Pay-it-forward offers an individual a free or subsidized service then an opportunity to voluntarily donate and/or create a postcard message to support future people. This study aims to assess the effectiveness of pay-it-forward as compared to standard-of-care self-paid vaccination to improve HPV vaccine uptake among adolescent girls aged 15–18 years, who are …

Sheprep: Examining The Influence Of The Messaging And The Messenger Associated With Prep Uptake Among African American Women, Christian C. Spears

College of Graduate Studies: Theses & Dissertations

African American Women (AAW) make up less than 15% of the female population in the United States but account for over 50% of new HIV diagnoses among females. This largely preventable health disparity can be mitigated by advocating and prescribing Pre-exposure Prophylaxis (PrEP), a preventive HIV medication, to persons at risk. Despite advances in medication options, there are less than 13% of Black people who could benefit from having been prescribed PrEP, and limited research and promotion on the effectiveness of PrEP for AAW. The “ShePrEP Study” aimed to assess awareness, perceptions, and receptivity toward PrEP among AAW. This study …

Documenting The Presence Of Chagas Disease In Prehistoric North America: Applying The Stockholm Paradigm To Archaeoparasitology, Part Ii, Karl J. Reinhard, Daniel R. Brooks, Aida Romera Barbera, T. Michael Fink

Karl Reinhard Publications

The DAMA protocol (Document, Assess, Monitor, Act) is the applied aspect of the Stockholm Paradigm. Evidence from archaeology and history of medicine has a demonstrated value in documenting infection risk for specific study areas. Bioarchaeological remains and historical documents show vivid examples of pathology related to the Chagas disease life cycle. The science of archaeology defines the lifestyles that created risk of triatomine kissing bug infestations and trypanosome protozoa infections. Paleogenetics, in the form of molecular analyses of Trypanosoma cruzi, elucidate the temporal origins of genetic variants and adaptation to human environments. We illustrate how these fields reveal the risk …

Exploring The Evolution Of Trypanosoma Cruzi And The Emergence Of Chagas Disease In The Context Of Environmental Change: Applying The Stockholm Paradigm To Archaeoparasitology, Part I, Aida Romera Barbera, Daniel R. Brooks, T. Michael Fink, Karl J. Reinhard

Karl Reinhard Publications

The Stockholm Paradigm is an evolutionary synthesis that explains the emergence of novel pathogens in the context of environmental disturbances. Considering the urgent climate change situation, anticipation stands as key to prevent and mitigate the effects that climate change can have in the emergence of pathogens. However, the success of preventive measures is hindered by a limited knowledge of the interplaying dynamics between biology, environment, and culture leading to emerging infectious diseases. For many decades, bioarchaeologists have been gathering data on past human-environment interactions, therefore contributing to the conversation. Archaeoparasitology, at the intersection between pathology, bioarchaeology, and biology, is uniquely …

Analysis Of The Relationship Between Children's Characteristics, Family Characteristics, Food Intake, Eating Habits, And Disease History With Nutritional Status Of Under-Five Children Based On The Composite Index Of Anthropometric Failure In Karangkamulyan Village, Cihara District, Lebak Regency, Indonesia In 2020, Ayu Anisadiyah, Ratu Ayu Dewi Sartika

Indonesian Journal of Public Health Nutrition (IJPHN)

The Composite Index of Anthropometric Failure (CIAF) is an indicator of composite nutritional status assessment (BB/U, PB/U, and BB/PB) to describe all under-five children’s nutritional problems. In 2020, malnutrition, unemployment, and poverty in Banten Province were high, and the population's income tends to be low. Karangkamulyan Village is an underdeveloped village with mining areas. This study aims to determine the factors related to the nutritional status of under-five children based on CIAF in Karangkamulyan Village in 2020. The study used a cross-sectional study design and a systematic random sampling technique. The research sample was 141 under-five children aged 24-59 months. …

Sleep Quality And Affecting Factors Among Elderly Living In A Nursing Home In East Nusa Tenggara Indonesia, Asyifa Robiatul Adawiyah, Kusharisupeni Djokosujono, Jumiati Lelu Sanga

Indonesian Journal of Public Health Nutrition (IJPHN)

Sleep is one of the processes that greatly affects aging, It is essential for mental, physical, and maintenance of physical health. A research study was conducted in a public nursing home in Kupang East Nusa Tenggara Indonesia. This study aimed to analyze the sleep quality and the factors affecting sleep quality, among old age living in the nursing home. The research design was cross-sectional with primary data on 103 elderly living in nursing homes. There was a relationship between age, gender, marital status, spouse, educational background, have a chronic disease, living arrangement, anxiety, and depression with sleep quality (p

Availability Of Sugar-Sweetened Beverages At Home As The Dominant Factor Related To Its Consumption Among Students Of Sman (State High School) 47 Jakarta, Indonesia, In 2022, Nadhira Winindya Sari, Kusharisupeni Djokosujono, Diah Mulyawati Utari, Neni Rohayati

Indonesian Journal of Public Health Nutrition (IJPHN)

Sugar-sweetened beverages (SSBs) are drinks added with simple sugar, which can increase the energy because of calorie-dense and high in sugar, but low in other nutrients. Excessive consumption of SSBs can cause nutritional problems, such as increasing the risk of overweight and obesity. This study aims to determine the relationship between SSBs consumption and various factor and the dominant factor of SSBs consumption among students of SMAN (State High School) 47 Jakarta in 2022. The cross-sectional study was conducted from November 2021 to June 2022 with 120 respondents. Primary data was taken using questionnaires and analyzed by univariate, bivariate (chi-square …

Factors Associated With High Fat, Salt, And Sugar Food Selection On Online Food Delivery Service Among Students Of Sman (State High School) 47 Jakarta, Indonesia, In 2022, Arifiana Arifiana, Kusharisupeni Djokosujono, Wahyu Kurnia Yusrin Putra, Nina Muziana

Indonesian Journal of Public Health Nutrition (IJPHN)

In the use of Online Food Delivery Service (OFDS), an online service applying a smartphone to make it easier for users to get food quickly, it was found that the foods selected tend to be unhealthy and may increase the risk of being overweight. The aim of this study was to determine predominant and other factors that differ in food selection in OFDS among students at SMAN (State High School) 47 Jakarta in 2022. This study applied a cross-sectional study design with 112 subjects. Data were taken through a questionnaire and analyzed by using an X²- test and multiple logistic …

The Association Between Feeding Practices And History Of Diarrhea With Nutritional Status Of Toddlers, Lulu Indria Setyani, Khoirul Anwar

Indonesian Journal of Public Health Nutrition (IJPHN)

The age of 0-59 months is a phase of basic life formation that is vulnerable to nutritional problems—causes such as infectious diseases and parenting. This research aims to analyze the relationship between feeding practices and a history of diarrhea with the nutritional status of children under five. This study used a cross-sectional design. Samples were taken by purposive sampling of as many as 96 toddlers. Data were collected by direct measurement of weight scales, stature meters, and interviews using the main questionnaire and the modified CFQ questionnaire. The statistical tests used were the chi-square test and fisher's exact test. A …

Does Crime Trigger Genetic Risk For Type 2 Diabetes In Young Adults? A G X E Interaction Study Using National Data, Fangqi Guo, Kathleen Mullan Harris, Jason D. Boardman, Jennifer W. Robinette

Psychology Faculty Articles and Research

Background

Living in neighborhoods perceived as disordered exacerbates genetic risk for type 2 diabetes (T2D) among older adults. It is unknown whether this gene-neighborhood interaction extends to younger adults. The present study aims to investigate whether crime, an objectively measured indicator of neighborhood disorder, triggers genetic risk for T2D among younger adults, and whether this hypothesized triggering occurs through exposure to obesity.

Methods

Data were from the Wave I (2008) National Longitudinal Study of Adolescent to Adult Health. A standardized T2D polygenic score was created using 2014 GWAS meta-analysis results. Weighted mediation analyses using generalized structural equation models were conducted …

Men’S Stories: An Account Of Translating Vaccine Decision Narratives From Young Men In The U.S. Into A Targeted Public Health Intervention, Michelle Miller-Day, Erin S. Craw, Diana Harris, Michael L. Hecht

Communication Faculty Articles and Research

Effective interventions to promote human papillomavirus (HPV) vaccination are needed for all young adults across the globe. Yet, most public health efforts focus on HPV-related risks for females. Unfortunately, HPV-related cancers in men are also a concern, as is the potential for men to spread HPV to their partners. The HPV vaccine is highly effective in reducing risks related to these cancers. Yet, vaccination rates among young males are low and their vaccination concerns are not well understood. This project conducted 15 in-depth qualitative interviews with U.S. males aged 18–22 to hear their vaccine decision stories. Themes of HPV vaccination …

The Impact Of Hpv Vaccine Narratives On Social Media: Testing Narrative Engagement Theory With A Diverse Sample Of Young Adults, Amy E. Leader, Michelle Miller-Day, Rikishi T. Rey, Preethi Selvan, Anne E. Pezalla, Michael L. Hecht

Communication Faculty Articles and Research

Rates of human papillomavirus (HPV) infection are highest in young adults, who can be vaccinated against HPV if they were not vaccinated as adolescents. Since young adults increasingly access health information on social media, we tested the impact of a social media campaign with narrative-based health information on intentions related to HPV vaccination. We also aimed to understand which ads resonated most with young adults and led to higher survey completion rates. We created social media posts featuring videos promoting HPV vaccination. We launched a sponsored ad campaign on Facebook to reach young women, ages 18–26, across the country. Participants …

A Case Of Adult Multisystem Inflammatory Syndrome Following Covid-19 Vaccine, Meghan Brown, Nika Zorko Garbajs, Simon Zec, Hisham Mushtaq, Anwar Khedr, Abbas Bashir Jama, Ibtisam Rauf, Mikael Mir, Aishwarya Reddy Korsapati, Shikha Jain, Thoyaja Koritala, Ramesh Adhikari, Amos Lal, Ognjen Gajic, Juan Pablo Domecq, Sarah Goksoy, Brian Bartlett, Amit Sharma, Nitesh Kumar Jain, Syed Anjum Khan

Journal of Community Hospital Internal Medicine Perspectives

Multisystem inflammatory syndrome is a life-threatening condition associated with elevated inflammatory markers and multiple organ injury. A diagnosis of exclusion, it has been reported after severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2) in children and adults; recently it has been described in some post-COVID-19 vaccinated individuals. The prognosis with supportive care and immunomodulatory therapy is good, although some individuals may require treatment in the intensive care unit (ICU). Here we report a case of a 58-year-old man who developed multi-organ failure after receiving the second dose of the Moderna mRNA-1273 COVID-19 vaccine. He required critical organ support in the …

Total Prevention: A History Of Schistosomiasis In Japan, Alexander Bay

History Faculty Articles and Research

In Japan, schistosomiasis was endemic in Yamanashi Prefecture and a few other hotspot areas where the Miya’iri snail lived. The parasite’s lifecycle relied on the intermediary Miya’iri snail as well as the human host. Parasite eggs passed into the agrarian environment through untreated night soil used as fertiliser or through the culture of open defecation in rural Japan. Manmade rice fields and irrigation ditches, night soil covered paddies and highly refined growing seasons put people in flooded rice paddies to intensively work the land in the spring and summer. The disease was equally dependent on human intervention in the natural …

Implementation And Evaluation Of A Syphilis Screening Tool To Increase Patient Testing For Syphilis Among Adults 18 Years And Older In A Rural Primary Care Clinic, Valeria S. Wiggins

Doctor of Nursing Practice Projects

Background: Sexually transmitted infections (STIs) are an increasing epidemic in the United States (U.S.) that need immediate interventions to reverse the effects of syphilis on the sexual health of adults in rural populations. Many are unaware of the growing rate of syphilis and the overall impact it causes nationally. When syphilis is detected early, it can be easily treated and cured. Rural primary care providers are ideal candidates for implementing education, screening, testing, and treatment.

Purpose: The Doctor of Nursing Practice (DNP) project aims to increase the frequency of screening patients in rural primary care clinics for high-risk sexual behaviors. …

Meta-Analysis Of 175 Patients With Covid-19 And Seizures, Status Epilepticus, Or Cortical Myoclonus: An Individual Patient Data Analysis, Aditi Kappagantu Bs, Helena A. Brantz Ms, Amman Bhasin Ba, Cristina Jageka Bs, Rooqash Ali Md, Izzy Saef Md, Brittany M. Stopa Mph, Ayaz Khawaja Md

Medical Student Research Symposium

Objective

To characterize management and outcomes of seizures, status epilepticus, and cortical myoclonus in COVID-19, with individual patient data analysis of published literature.

Methods

Systematic literature review was conducted in accordance with PRISMA guidelines. Criteria included new-onset seizures, status epilepticus, and/or cortical myoclonus with concomitant COVID-19. COVID-19 severity was dichotomized into mild and severe cases. Good outcome was defined as discharge without severe deficits, and/or return to baseline.

Results

A total of 105 studies reporting 176 patients (male 56.3%;mean age 47.8,SD 25.6) were included. Status epilepticus occurred in 47 patients (26.7%) and myoclonus in 41 (23.3%). Severe COVID-19 occurred in …

Utility Of The Motivation To Change Lifestyle And Health Behaviors For Dementia Risk Reduction Scale (Mclhb-Drr) Based On A North American Sample, Angelina E. Witbeck

Dissertations

As the population ages, the prevalence rates of dementia continue to increase. Without a cure or promising treatment for dementia, the best course of lowering the prevalence rates of dementia is through preventative measures. Through an electronic survey, the study utilized the MCLHB-DRR scale to determine whether (1) gender, age, educational background, and socioeconomic status will impact the motivational factors to change lifestyle and health behaviors to reduce the risk of developing dementia and (2) direct experiences with individuals that have a dementia diagnosis are likely to impact one's motivational factors to change lifestyle and health behaviors to reduce the …

Covid-19 Vaccine Mandate, Mikhail Kun, Tatiana Ryzhakova

Publications and Research

The COVID-19 pandemic has wreaked havoc on the planet and killed millions of people. Health care workers and radiology technicians who come into direct contact with COVID-19 patients have indeed been the most affected by the virus. Since the pandemic began, the COVID-19 cases among health care workers have surged and quadrupled. COVID-19 vaccine mandate is the need of the time. Mandates have a history and are in effect for other diseases such as smallpox, measles, or mumps. But since the vaccines have come out for COVID-19, there is a public impetus to condemn these vaccines, based on the false …

Emotional Eating Among Final Year Undergraduate Female Students Of Faculty Of Public Health Universitas Indonesia During Covid-19 Pandemic In 2021, Adinda Safira Salsabiela, Wahyu Kurnia Yusrin Putra

Indonesian Journal of Public Health Nutrition (IJPHN)

Emotional eating is defined as the tendency to excessively consuming food which often high in sugar, salt, and fat levels in response to negative emotions. Uncontrolled emotional eating will increase the risk of eating disorders such as bulimia nervosa and binge-eating disorder, obesity, cardiovascular diseases, and type II diabetes. This study aims to find out about the relationship between perceived stress, anxiety, academic stressors, social media engagement, COVID-19 infection history in respondent and their family members, and mindfulness with emotional eating among 106 final year undergraduate female students of the Faculty of Public Health Universitas Indonesia during the COVID-19 pandemic …

Carbohydrate Intake Is Associated With Learning Concentration Among High School Students In Jember Regency, East Java Province, Indonesia, Nadya Parahita Handini, Triyanti Triyanti, Kusharisupeni Djokosujono

Indonesian Journal of Public Health Nutrition (IJPHN)

Low learning concentration will have impact on low academic performance. This study aims to determine the relationship between learning concentration and several factors and to find the most dominant factor in the students of SMAN 1 Jember. In this study, learning concentration was the dependent variable, while breakfast habits, nutrient intake (energy, carbohydrates, protein, fat, iron, zinc, vitamin B12, vitamin C), sleep quality, and physical activity were independent variables. This research is a quantitative study with cross-sectional design. This study conducted in June 2021 at SMAN 1 Jember with a total of 200 respondents who were selected using the quota …

Current Intake And Infection Status Were Not Good Predictive Factors Of Stunting Among Children Aged 6-59 Months In Babakan Madang Sub-District, Bogor District, West Java, Indonesia, Ruth Desinta Purnamasari, Ratu Ayu Dewi Sartika, Trini Sudarti

Indonesian Journal of Public Health Nutrition (IJPHN)

This study aims to discover the prevalence of stunting and determine the associations between the history of pulmonary tuberculosis disease with the prevalence of stunting among children under five years of age (6-59 months) in Babakan Madang Sub-District, Bogor District 2019. This study uses a cross-sectional design with a quantitative approach. The sample in this research was 194 children under five obtained by cluster sampling. Data collection was conducted through May 2019. The data collection process includes anthropometric measurements using calibrated microtoise and digital length board, dietary assessment using 1 x 24-h food recall, and a self-administered questionnaire. Data analyses …

Nutrition Analysis Of Wood Apple (Limonia Acidissima), Yuliana Noor Setiawati Ulvie, Hapsari Sulistya Kusuma, Erma Handarsari

Indonesian Journal of Public Health Nutrition (IJPHN)

Wood apple or Limonia acidissima contains fruit acid, vitamins, and minerals. The dry fiber of the fruit contains 15% citric acid, potassium, calcium, and iron salt. The seed and pulp contain fats and protein. The fats consist of palmitic acid, oleic acid, linoleic acid, and linolenic acid, despite palmitoleic and stearic acid traces. β-sitosterol, β-Amirin, lupeol, and stigmasterol are from the unsaponifiable matter of seed oil. It was descriptive research that employed a laboratory experiment approach to determine the composition of total carbohydrate, total protein, total fats, water, ash content, and the crude fiber of wood apple. The research found …

Effect Of Health And Nutrition Education On Blood Pressure, Knowledge And Compliance Among Hypertensive Patients In Bogor District, Indonesia: A Control Quasi-Experiment, Nurul Dina Rahmawati, Hasbullah Thabrany, Ratu Ayu Dewi Sartika

Indonesian Journal of Public Health Nutrition (IJPHN)

With a high prevalence of hypertension (25.8% in 2013 and 34.1% in 2018), Indonesia currently deals with a tremendous health economic burden with the implementation of National Health Insurance (JKN). Hypertension is known to lead to severe complications and productivity loss. This study aimed to evaluate the effect of health and nutrition education on blood pressure knowledge and compliance among hypertension patients. The study was conducted over a period of 6 months in Bogor District. A total of 179 patients (64%) completed the study (intervention n = 88, control n = 91). Compared to the control group, patients in the …

Obesogenic Environments And Cardiovascular Disease: A Path Analysis Using Us Nationally Representative Data, Fangqi Guo, Georgiana Bostean, Vincent Berardi, Alfredo J. Velasquez, Jennifer W. Robinette

Psychology Faculty Articles and Research

Introduction

People living in obesogenic environments, with limited access to healthful food outlets and exercise facilities, generally have poor health. Previous research suggests that behavioral risk factors and indicators of physiological functioning may mediate this link; however, no studies to date have had the requisite data to investigate multi-level behavioral and physiological risk factors simultaneously. The present study conducted serial and parallel mediation analyses to examine behavioral and physiological pathways explaining the association between environmental obesogenicity and cardiovascular disease (CVD).

Methods

This cross-sectional observational study used data from the 2012–2016 Health and Retirement Study, a representative survey of US older …

A Whole-Food Plant Based Diet And Its Effects On Cardiovascular Disease, Meredith A. Childress

MSN Capstone Projects

The purpose of this paper and benchmark study is to present evidenced-based data regarding the impact diet choices have on heart disease and how adherence to a whole food plant based (WFPB) diet compared to a Western diet affects cardiac disease. The PICOT question being asked for this change project is as follows: In adults with history of cardiac disease (P), how does adherence to a whole-food plant-based (WFPB) diet (I) compared to the Western diet (C) impact outcomes associated with coronary artery disease (CAD) (O) over three months (T)? A search of evidenced-based literature was conducted to determine the …

A Quantitative Analysis Of The Efficacy Of Various Essential Oils Against The Sars Cov-2 Virus, Elizabeth Wagstaff, Chandrelyn Kraczek, Jack Brandon Lopez

Annual Research Symposium

A poster presentation and abstract for the Roseman Symposium. The project focuses on testing 3 essential oil blends and two disinfectants containing an essential oil blend against SARS CoV-2 in response to the COVID-19 pandemic. The project procedure involves plaque assays, disinfection, and neutralization techniques.

The Role Of Actin Associated Sptbn1 Host Factor In Hiv-1 Infection In Microglial Cells, Hannah Matheney

Graduate Theses/Dissertations

Human immunodeficiency virus (HIV) is a chronic illness affecting more than 32.7 million individuals worldwide. The virus infects immune cells, weakening the immune system overtime eventually leading to acquired immunodeficiency syndrome (AIDS) if left untreated. Infection starts with a fusion step, followed by uncoating of the HIV capsid once in the cytoplasm of the cell. HIV uses host cell proteins to complete the infection process, like the actin associated factor, SPTBN1. The Hulme lab has previously shown that SPTBN1 knockdown by siRNA in microglial cells decreased HIV infection and delayed uncoating of HIV. Because fusion is prior to uncoating, it …

Covid-19 Vaccine Disparities And Attitudes, Deonne Cartwright, Meryem Saygili

Pursue: Undergraduate Research Journal

The past couple of years have caused so much uncertainty and grief amidst the global pandemic. The goal of this study is to explore the attitudes behind COVID-19 vaccination to address the cause for vaccine disparities and help minimize health disparities in the United States. The study considers two multivariable regressions in SPSS of the social factors on vaccination status and vaccine confidence. This model studies the relationship between one’s ethnicity, race, education level, education specialization, household income, political ideology, and media source on vaccine confidence and vaccination status on an East Texas college campus. A campus-wide survey was conducted …

Point Of Care Spirometry Assessment For Pediatric Asthma Prevalence In A Family Homeless Shelter In Omaha, Nebraska, Nathaniel Mattison, Dale Agner, Breanne Parets, Haley Mathews, Emily Saliga, Maria Vacha, Jamicah Harris, Ryan Saliga

Graduate Medical Education Research Journal

Abstract:

Introduction: The few studies on pediatric asthma in US homeless shelters describe a 27.9 – 39.8% prevalence, and historically Omaha has had a high incidence of fatal pediatric asthma. Thereby, Clarkson Family Medicine (CFM) residency began a pediatric asthma outreach to a local family-homeless shelter to assess the prevalence of pediatric asthma and follow-up appointment attendance.

Methods: We obtained a voluntary parent-child assessment of the child’s respiratory history and an Asthma Control Test (ACT) between ages 4-18 for children residing at the family-homeless shelter. We obtained a pre-albuterol and post-albuterol mobile spirometer assessment using the Global Initiative for …