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Full-Text Articles in Health and Medical Physics
Epid-Based Dose Verification For Adaptive Radiotherapy, Joseph Gardner
Epid-Based Dose Verification For Adaptive Radiotherapy, Joseph Gardner
Theses and Dissertations
Dose verification is a critical component of adaptive radiotherapy, as it provides a measurement of treatment delivery success. Based on the measured outcome, the plan may be adapted to account for differences between the planned dose and the delivered dose. Although placement of an EPID behind the patient during treatment allows for exit dosimetry which may be used to reconstruct the delivered patient dose via backprojection of the fluence, there have not been any studies examining the basic assumption of backprojection-based dose verification: that deviations between the expected and delivered exit fluences are totally caused by errors in the delivered …
Fabrication And Characterization Of Thinner Solid-State Nanopores, Denis Forbi Tita
Fabrication And Characterization Of Thinner Solid-State Nanopores, Denis Forbi Tita
Graduate Theses and Dissertations
Solid State nanopores that are fabricated by the ion beam sculpting process and electron beam drilling have shown great promise as a sensing device for DNA and protein molecules. Even though biological pores such as the alpha-Haemolysin have been in use for quite some time, the use of solid state Nanopores in single biomolecule detection has been on the rise since the mid 1990s. Solid State nanopores have an advantage over biological pores in that they are more robust, stable, and can be sculpted to any desired size for use in translocation experiments. One of the major challenges in Nanopore …
Validation Of 3'-Deoxy-3'-[18f]-Fluorothymidine Positron Emission Tomography For Image-Guidance In Biologically Adaptive Radiotherapy, Marian Axente
Validation Of 3'-Deoxy-3'-[18f]-Fluorothymidine Positron Emission Tomography For Image-Guidance In Biologically Adaptive Radiotherapy, Marian Axente
Theses and Dissertations
Accelerated tumor cell repopulation during radiation therapy is one of the leading causes for low survival rates of head-and-neck cancer patients. The therapeutic effectiveness of radiotherapy could be improved by selectively targeting proliferating tumor subvolumes with higher doses of radiation. Positron emission tomography (PET) imaging with 3´-deoxy-3´-[18F]-fluorothymidine (FLT) has shown great potential as a non-invasive approach to characterizing the proliferation status of tumors. This thesis focuses on histopathological validation of FLT PET imaging specifically for image-guidance applications in biologically adaptive radiotherapy. The lack of experimental data supporting the use of FLT PET imaging for radiotherapy guidance is addressed by developing …