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Sperm Mitochondrial Dna Biomarkers As A Measure Of Male Fecundity And Overall Sperm Quality, Allyson Rosati
Sperm Mitochondrial Dna Biomarkers As A Measure Of Male Fecundity And Overall Sperm Quality, Allyson Rosati
Masters Theses
Introduction. Sperm parameter analysis is the standard method of male fecundity testing; however, minimal evidence supports associations between individual sperm parameters and reproductive outcomes. Our previous work shows strong associations between sperm mitochondrial DNA copy number (mtDNAcn) and time-to-pregnancy (TTP) in general populations, and between mtDNAcn and fertilization outcomes in clinical populations. Thus it is possible for sperm mtDNA biomarkers to act as summary measures of semen quality. In this study, we developed a sperm quality index (SQI) from semen parameters and compared its ability to measure fecundity to sperm mtDNAcn.
Methods. We received 384 semen samples from the Longitudinal …