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Full-Text Articles in Epidemiology
Colonization With Antibiotic-Susceptible Strains Protects Against Methicillin-Resistant Staphylococcus Aureus But Not Vancomycin-Resistant Enterococci Acquisition: A Nested Case-Control Study, Susan S. Huang, Rupak Datta, Sheryl Rifas-Shiman, Ken Kleinman, Hilary Placzek, Julie D. Lankiewicz, Richard Platt
Colonization With Antibiotic-Susceptible Strains Protects Against Methicillin-Resistant Staphylococcus Aureus But Not Vancomycin-Resistant Enterococci Acquisition: A Nested Case-Control Study, Susan S. Huang, Rupak Datta, Sheryl Rifas-Shiman, Ken Kleinman, Hilary Placzek, Julie D. Lankiewicz, Richard Platt
Public Health Department Faculty Publication Series
INTRODUCTION:
Harboring sensitive strains may prevent acquisition of resistant pathogens by competing for colonization of ecological niches. Competition may be relevant to decolonization strategies that eliminate sensitive strains and may predispose to acquiring resistant strains in high-endemic settings. We evaluated the impact of colonization with methicillin-sensitive Staphylococcus aureus (MSSA) and vancomycin-sensitive enterococci (VSE) on acquisition of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), respectively, when controlling for other risk factors.
METHODS:
We conducted a nested case-control study of patients admitted to eight ICUs performing admission and weekly bilateral nares and rectal screening for MRSA and VRE, respectively. Analyses were …