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2019

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Articles 121 - 150 of 173

Full-Text Articles in Environmental Public Health

Preventing Infectious Hematopoietic Necrosis In Salmonid Fish Along The Columbia River Basin, Whitney L. Wright Apr 2019

Preventing Infectious Hematopoietic Necrosis In Salmonid Fish Along The Columbia River Basin, Whitney L. Wright

OHSU-PSU School of Public Health Annual Conference

Infectious hematopoietic necrosis virus (IHNV) is a member of the Rhabdoviridae family and causes infectious hematopoietic necrosis (IHN) disease in many salmonid species during the juvenile or “fry” stage of life. IHNV is endemic to Western North America and occurs in the Columbia River Basin, where Steelhead and Chinook salmon are the most abundant IHNV-vulnerable species. IHNV can cause an epidemic in wild or farmed stocks, killing 90-95 percent of the fish it infects. Transmission is currently understood to occur by direct exposure through the gills, and the virus is shed typically from asymptomatic or clinically ill carrier adults at …


Interrupted Progress: Water And Sanitation In Haiti, Emily Bauer Apr 2019

Interrupted Progress: Water And Sanitation In Haiti, Emily Bauer

Thinking Matters Symposium Archive

Haiti has faced damaging environmental and social impacts, which have interrupted progress towards clean drinking water and adequate sanitation facilities for its over 10 million people. Natural disasters, disease outbreak, political corruption and economic instability have contributed to poor health and social outcomes for the small, island nation. This study used the most recent data from the World Health Organization and United Nations Children’s Fund Joint Monitoring Programme (WHO/UNICEF JMP) to assess national trends in water source and sanitation facility improvements from 1990-2015. WHO/UNICEF JMP defines water improvements as piped or non-piped protected water, and sanitation improvements as networked, flushed …


Measuring The Effects Of Thc On Human Sperm Parameters Using Biomonitoring Analysis, Roxana Amaya-Fuentes, Heather Young, Courtney Irwin, Jonathan Crites, David Moody, Melissa Perry Apr 2019

Measuring The Effects Of Thc On Human Sperm Parameters Using Biomonitoring Analysis, Roxana Amaya-Fuentes, Heather Young, Courtney Irwin, Jonathan Crites, David Moody, Melissa Perry

GW Research Days 2016 - 2020

Marijuana is one of the most common substances used in the United States with more men utilizing marijuana compared to women. The effects of marijuana on the brain are well known, however, there is limited research on its effects on human sperm parameters. We examined the association between THC and human sperm parameters in participants in the Washington D.C. area. Our preliminary results suggested that THC was associated with low sperm morphology.

Background: Marijuana has a long history of human usage for medicinal, ceremonial, and religious purposes. As of January 2018, nine states including Washington D.C. have legalized it for …


Isoprene Emission Rates From Extreme Heat Exposure Due To Climatic Changes On Quercus And Populus Tree Genera: A Systematic Review, Isabella Kaser, Susan Anenberg Apr 2019

Isoprene Emission Rates From Extreme Heat Exposure Due To Climatic Changes On Quercus And Populus Tree Genera: A Systematic Review, Isabella Kaser, Susan Anenberg

GW Research Days 2016 - 2020

This systematic literature review explores whether isoprene emission rates from common tree species would be exacerbated in a warming world. When isoprene reacts with other pollutants, such as nitrogen oxides, tropospheric ozone is formed. Ozone is harmful to human health and is shown to decrease lung function among many other negative respiratory effects. If the rates of emissions continue at their current levels, there may be increased rates of asthma-related ED visits and respiratory diseases among the general population.


Acute Particulate Matter Exposure And Suicide In North East Asia: A Literature Review, Shannon Haines, Lance Price, Amanda Northcross Apr 2019

Acute Particulate Matter Exposure And Suicide In North East Asia: A Literature Review, Shannon Haines, Lance Price, Amanda Northcross

GW Research Days 2016 - 2020

A systematic literature review was conducted on research exploring the relationship between acute exposures to ambient particulate matter and changes in suicide rates in North East Asian countries. From the eight studies analyzed limited evidence was found and additional research about the association is suggested.


Occupational Risk Of Migrant Farm Workers In North Carolina: A Systematic Review, Ellie Ginsberg, David Michaels Apr 2019

Occupational Risk Of Migrant Farm Workers In North Carolina: A Systematic Review, Ellie Ginsberg, David Michaels

GW Research Days 2016 - 2020

Latnix Migrant Farmworkers in North Carolina face a variety of occupational hazards while working in the fields. These hazards include exposure to the natural elements, pesticides, and tobacco. Sub standard housing conditions and lack of comprehensive workers compensation coupled with these hazards create an extremely dangerous working environment for these farmworkers.


Does Food Insecurity Predict Obesity And Educational Achievement: A Systematic Literature Review, Emily Youner, Ami Zota Apr 2019

Does Food Insecurity Predict Obesity And Educational Achievement: A Systematic Literature Review, Emily Youner, Ami Zota

GW Research Days 2016 - 2020

The objective of this study was to determine whether food availability predicts health outcomes among children in the U.S., such as obesity rates and academic performance. Though there was some inconsistency in the findings, based on the Navigation Guide methodology, we concluded that there is inadequate evidence of correlation between food insecurity and obesity rates, yet limited evidence of correlation between food insecurity and educational achievement. Given these findings, further research is warranted to inform policy action to mitigate the effects food insecurity.


Cognitive And Behavioral Effects Of Nitrogen Dioxide Exposure In Primary School Children: A Systematic Review, Dara L. Brown, Matias Attene Ramos Apr 2019

Cognitive And Behavioral Effects Of Nitrogen Dioxide Exposure In Primary School Children: A Systematic Review, Dara L. Brown, Matias Attene Ramos

GW Research Days 2016 - 2020

A systematic literature review was conducted to identify relevant studies evaluating the relationship between nitrogen dioxide emissions and cognitive and behavioral health in children. Eight studies were identified, reviewed, and analyzed according to specific inclusion criteria. The results of the review show that there is strong evidence for an inverse relationship between nitrogen dioxide exposure and cognitive and behavioral health in primary school children. However, further research is needed to confirm the observed associations between nitrogen dioxide exposure and cognitive and behavioral health.


Asthma-Related Health Outcomes In New Jersey After A Natural Disaster Event, My Ngoc Thuy Nguyen Apr 2019

Asthma-Related Health Outcomes In New Jersey After A Natural Disaster Event, My Ngoc Thuy Nguyen

Health Services Research Dissertations

The occurrence of a natural disaster event such as a hurricane may further hinder the asthma management of asthmatic individuals. Unmanaged asthma has led to increased work absenteeism, preventable emergency department visits, costly hospitalizations and possibly death in severe cases. To improve asthma management in asthmatic adults in New Jersey (NJ) following a natural disaster event, this study examined whether predisposing, enabling and need factors are predictors for asthma exacerbation and asthma-related health care utilization in New Jersey. A retrospective secondary analysis of New Jersey Behavioral Risk Factor Surveillance System (NJBRFSS) data and New Jersey Asthma Call Back Survey (NJACBS) …


Ecological Determinants Of Respiratory Health: Examining Associations Between Asthma Emergency Department Visits, Diesel Particulate Matter, And Public Parks And Open Space In Los Angeles, California, Jason A. Douglas, Reginald S. Archer, Serena E. Alexander Mar 2019

Ecological Determinants Of Respiratory Health: Examining Associations Between Asthma Emergency Department Visits, Diesel Particulate Matter, And Public Parks And Open Space In Los Angeles, California, Jason A. Douglas, Reginald S. Archer, Serena E. Alexander

Health Sciences and Kinesiology Faculty Articles

Los Angeles County (LAC) low-income communities of color experience uneven asthma rates, evidenced by asthma emergency department visits (AEDV). This has partly been attributed to inequitable exposure to diesel particulate matter (DPM). Promisingly, public parks and open space (PPOS) contribute to DPM mitigation. However, low-income communities of color with limited access to PPOS may be deprived of associated public health benefits. Therefore, this novel study investigates the AEDV, DPM, PPOS nexus to address this public health dilemma and inform public policy in at-risk communities. Optimized Hotspot Analysis was used to examine geographic clustering of AEDVs, DPM, and PPOS at the …


Yielding To The Necessities Of A Great Public Industry: Denial And Concealment Of The Harmful Health Effects Of Coal Mining, Caitlyn Greene, Patrick Charles Mcginley Mar 2019

Yielding To The Necessities Of A Great Public Industry: Denial And Concealment Of The Harmful Health Effects Of Coal Mining, Caitlyn Greene, Patrick Charles Mcginley

William & Mary Environmental Law and Policy Review

In the mid-nineteenth century, coal mined in Central Appalachia began to flow into industrial markets. Those mines and the coal they produced provided jobs, put food on family tables in coalfield households, and even provided housing for hundreds of thousands of coal miners and their families. The bounty from America’s expanding coalfields fueled the Industrial Revolution and powered the nation’s steel mills, factories,steamboats, and railroads. It powered America’s defense through two World Wars and later military conflicts. Coal-fired power plants generated more than half of the electricity used in the United States in the latter quarter of the twentieth century. …


Electronic Cigarettes In The Indoor Environment, Cheryl Marcham Mar 2019

Electronic Cigarettes In The Indoor Environment, Cheryl Marcham

Publications

This presentation covers the development of electronic cigarettes and presents statistics related to their manufacture and use. Also included are facts about how addictive the products are, especially to young people, who are particularly vulnerable to addiction. The FDA has begun work to end sales of e-cigarette products to minors. Included in the presentation are formulae for the various vaping products, which are not healthy for users or people in their vicinity. Telephone calls to poison call centers increased drastically from 2010 to 2014.


An Iterative Process For Training Design And Implementation Increased Health Workers' Knowledge For Taking Nutrition Behavior Change To Scale, Wendy Gonzalez, Anabelle Bonvecchio Arenas, Armando García-Guerra, Mireya Vilar-Compte, Alejandría Villa De La Vega, Laura Quezada, Cynthia Rosas, Ana Lilia Lozada-Tequeanes, Amira Hernández Mar 2019

An Iterative Process For Training Design And Implementation Increased Health Workers' Knowledge For Taking Nutrition Behavior Change To Scale, Wendy Gonzalez, Anabelle Bonvecchio Arenas, Armando García-Guerra, Mireya Vilar-Compte, Alejandría Villa De La Vega, Laura Quezada, Cynthia Rosas, Ana Lilia Lozada-Tequeanes, Amira Hernández

Department of Public Health Scholarship and Creative Works

The shortage of skilled, motivated, and well-supported health workers is a major barrier to scaling up nutrition interventions and services. Objective: The objective of this study is to describe the process for developing and implementing a training of health personnel for the delivery of the Integrated Strategy for Attention to Nutrition (EsIAN), an evidence-based strategy for promoting infant and young child feeding through primary health care in Mexico. The specific objective is to provide a case study and highlight challenges, as well as elements to successfully mitigate these, and discuss potential applications of findings beyond the Mexican context. Methods: The …


Feeling Green: The Benefits Of Green Space On Urbanites' Mental Health, Kathryn A. Hoagland Mar 2019

Feeling Green: The Benefits Of Green Space On Urbanites' Mental Health, Kathryn A. Hoagland

Liberal Arts and Engineering Studies

This investigation intends to determine the best methods for incorporating public green space into dense urban areas, for the betterment of residents' mental health. Data from studies showing differences in the prevalence of anxiety and depression in urban and rural areas are discussed alongside data from studies looking at the effect that certain types of green space might have on mental health. While there is no exact consensus on the extent to which nature has positive effects on mental health there is enough of a correlation to argue for the implementation of public green spaces in urban design, in order …


Influence Of Decentralization And Type Of Patient On Loss To Follow-Up Among Multidrug-Resistant Tuberculosis Patients In Indonesia From 2014 To 2015, Noerfitri Noerfitri, R. Sutiawan, Tri Yunis Miko Wahyono, Pratiwi Ayuningtyas Hartono Feb 2019

Influence Of Decentralization And Type Of Patient On Loss To Follow-Up Among Multidrug-Resistant Tuberculosis Patients In Indonesia From 2014 To 2015, Noerfitri Noerfitri, R. Sutiawan, Tri Yunis Miko Wahyono, Pratiwi Ayuningtyas Hartono

Kesmas

Drug-resistant tuberculosis (TB) patients have a greater risk of loss to follow-up (LTFU) than drug-sensitive TB patients, due to their longer treatment duration. This study aimed to determine the influence of decentralization and patient type on LTFU among multidrug-resistant TB (MDR-TB) patients in Indonesia. A retrospective cohort study was conducted at all MDR-TB treatment healthcare facilities in Indonesia from 014 to 2015. Using total sampling technique, 961 patients were examined and sampled. Of these patients, 86.03% were decentralized. Patients were classified into types as follows: 35.17% were “relapse” patients, 5.52% were “new,” 13.94% were classified as “after LTFU” patients, 23.10% …


Relationship Model For Occupational Safety And Health Climate To Prevent Needlestick Injuries For Nurses, Ketut Ima Ismara, Adi Heru Husodo, Yayi Suryo Prabandari, Widodo Hariyono Feb 2019

Relationship Model For Occupational Safety And Health Climate To Prevent Needlestick Injuries For Nurses, Ketut Ima Ismara, Adi Heru Husodo, Yayi Suryo Prabandari, Widodo Hariyono

Kesmas

The risk of accidents and disease transmission when working at hospitals is quite high, especially in Indonesia. This study aimed to analyze the relationship model between the Occupational Safety and Health (OSH) climate and behavior intention in OSH performance to prevent needlestick injuries (NSI) based on a theory of planned behavior. A mixed approach using qualitative and quantitative methods was applied. Data were obtained from Structural Equation Model questionnaires, observation, and documentation, and interviews were analyzed qualitatively. The population was 1,042 nurses at Dr. Sardjito General Hospital in Yogyakarta. The sample consisted of 289 respondents determined by purposive random sampling …


Exclusive Breastfeeding And Decrease Of Upper Respiratory Infection Incidence Among Infants Aged 6-12 Months In Kampar District, Riau Province, Musfardi Rustam, Renti Mahkota, Nasrin Kodim Feb 2019

Exclusive Breastfeeding And Decrease Of Upper Respiratory Infection Incidence Among Infants Aged 6-12 Months In Kampar District, Riau Province, Musfardi Rustam, Renti Mahkota, Nasrin Kodim

Kesmas

Upper Respiratory Infection (URI) is a major cause of morbidity and mortality of infants and toddlers in developing countries. The high infant morbidity and mortality rates in Indonesia are associated with the low exclusive breastfeeding ability. Breast milk is a natural drink for newborns in the first month of life that is beneficial not only for the babies, but also for mothers. The aim of study was to determine exclusive breastfeeding and decrease in incidence of URI among infants aged 6-12 months. This study was conducted by using case control design. Samples were taken by using cluster random sampling. Subject …


The Consumption Of Fresh Vegetables From Street Food And Sanitation Of Street Stalls At Four Locations In Bogor City, Donna Fujie Rahaditha Utami, Winiati P. Rahayu, Lilis Nuraida Feb 2019

The Consumption Of Fresh Vegetables From Street Food And Sanitation Of Street Stalls At Four Locations In Bogor City, Donna Fujie Rahaditha Utami, Winiati P. Rahayu, Lilis Nuraida

Kesmas

The consumption of fresh vegetables at the stalls needs serious attention. This research aimed to estimate the exposure probability due to fresh vegetables consumption of street food consumers, to measure sanitation level of street stalls that serving fresh vegetables, and to recommend a mentoring program for the stalls at four locations in Bogor City. This research was conducted at 16 stalls located at four locations in Bogor City. The number of respondents surveyed was 293 people and determined by stratified sampling method. Food frequency questionnaire was used as a tool in the survey. The survey showed that men consumed more …


Perception Of People Living With Hiv/Aids On Social Stigma Of Hiv/Aids In Sukoharjo District, Titik Haryanti, Wartini Wartini Feb 2019

Perception Of People Living With Hiv/Aids On Social Stigma Of Hiv/Aids In Sukoharjo District, Titik Haryanti, Wartini Wartini

Kesmas

The stigma of wrong society about HIV / AIDS is one of the obstacles to prevention and control of HIV / AIDS in Sukoharjo District. This study aims to determine the relationship of characteristics, causal factors and duration of HIV / AIDS with the perception of people living with HIV to the stigma of society about HIV / AIDS in Sukoharjo District. The research used is analytical descriptive with cross sectional approach. The population is all people with HIV / AIDS until April 2016 amounted to 256 with a sample of 156 people with sampling technique quota sampling. Bivariate analysis …


Prediction Models For Descreasing Visual Acuity In Wig Makers, Nur Ulfah, Siti Harwanti, Ngadiman Ngadiman Feb 2019

Prediction Models For Descreasing Visual Acuity In Wig Makers, Nur Ulfah, Siti Harwanti, Ngadiman Ngadiman

Kesmas

One of the occupational diseases that can arise for workers with high accuracy is a decrease in their visual acuity. Therefore, it is necessary to study the risk factors of decreasing visual acuity in workers with high accuracy, such as in wig makers. This study aimed to examine the correlation between age, working period, lighting intensity, fatigue, and nutritional status with visual acuity, and to observe the main risk factors that can be used as a reference for predicting decreasing visual acuity. This study was an observational study that used a cross-sectional design. The population number for this study was …


Effect Of Condom Utilization On Sexuall Transmitted Infection Among Female Sex Workers, In Tulungagung District, East Java, Indonesia, Ainun Hanifah, Ari Natalia Probandari, Eti Poncorini Pamungkasari Feb 2019

Effect Of Condom Utilization On Sexuall Transmitted Infection Among Female Sex Workers, In Tulungagung District, East Java, Indonesia, Ainun Hanifah, Ari Natalia Probandari, Eti Poncorini Pamungkasari

Kesmas

One effective strategy for preventing sexually transmitted infection (STI) incidence and providing protection for female sex workers (FSWs) from their sexual partners is correct and consistent condom use behavior. This study examined the effect of condom use on STI among FSWs in Tulungagung District, East Java. This analytic and observational study using a cohort prospective design was conducted at Ngujang ex- prostitution area and Gunung Bolo prostitution area, Tulungagung District, from November to January 2017. The total sample selected was 90 FSWs. Data was collected through a set of questionnaires and tracking condom use in a diary. Data were analyzed …


Knowledge And Practice In Household Waste Management, Agnes Fitria Widiyanto, Suratman Suratman, Nisrina Alifah, Tri Murniati, Oktafiani Catur Pratiwi Feb 2019

Knowledge And Practice In Household Waste Management, Agnes Fitria Widiyanto, Suratman Suratman, Nisrina Alifah, Tri Murniati, Oktafiani Catur Pratiwi

Kesmas

Declining environmental quality is one of population caused by household consumption behavior. Some of the highest contaminant contributions are domestic waste, waste, and company waste. Waste contamination will lead to dead fish, decreased water quality and disease transmission. Community approach can be done to solve the waste problem, especially at the household level. This study uses quantitative methods to analyze the effect of intervention and waste management training on changes in household waste management knowledge and practices. This type of research uses quasi experiment with one group of pre and post test design. The results showed that there was an …


The Influence Of Immigrant Generation On Obesity Among Asian Americans In California From 2013 To 2014, Shaoqing Gong, Kesheng Wang, Ying Li, Arsham Alamian Feb 2019

The Influence Of Immigrant Generation On Obesity Among Asian Americans In California From 2013 To 2014, Shaoqing Gong, Kesheng Wang, Ying Li, Arsham Alamian

ETSU Faculty Works

Objectives We aimed to examine the association between immigrant generation and obesity among Californian adults and Asian Americans. Results Overall, 23.3% of the Asian population was obese, and 40.0% was overweight. The percentage of 1st, 2nd, and 3rd generation were 72.7%, 22.6%, and 4.6%, respectively. Overall, 1st generation of Asians had lower odds of being obese compared to Whites (OR = 0.34, 95%CI = 0.26–0.45). Multiple logistic regression analyses showed that overall, 2nd generation (OR = 1.69, 95%CI = 1.10–2.60) and 3rd generation (OR = 2.33, 95%CI = 1.29–4.22) Asians had higher odds of being obese compared to 1st generation …


Value Of Certification: The Occupational Safety And Health Professional, Cheryl Marcham Feb 2019

Value Of Certification: The Occupational Safety And Health Professional, Cheryl Marcham

Publications

This presentation provides information about the importance and value of attaining certification to determine health and safety issues in the environment. It also explains the advantages of attaining certification from different organizations, salary-wise. Attaining a certificate gives individuals the standardized knowledge needed to determine if situations/substances are harmful to human well being or the environment.


Evaluation Of An Educational Campaign To Improve The Conscious Consumption Of Recreationally Caught Fish, Corey A. Krabbenhoft, Susan Manente, Donna R. Kashian Jan 2019

Evaluation Of An Educational Campaign To Improve The Conscious Consumption Of Recreationally Caught Fish, Corey A. Krabbenhoft, Susan Manente, Donna R. Kashian

Environmental Science and Geology Faculty Research Publications

Consumption guidelines are a common way of improving conscious consumption behaviors in areas where game fish are known to contain contaminants. However, guideline information can be difficult to distribute, and effectiveness difficult to measure. To increase the distribution and effectiveness of guideline information for the Detroit River, an educational campaign was launched in 2010, which included distribution of pamphlets with consumption information, posting of permanent signs at popular fishing locations, and hiring River Walkers to personally communicate with anglers. In 2013 and 2015, we conducted in-person surveys of active shoreline anglers to determine the effectiveness of education and outreach efforts. …


Two-Stage Bagging Pruning For Reducing The Ensemble Size And Improving The Classification Performance, Hua Zhang, Yujie Song, Bo Jiang, Bi Chen, Guogen Shan Jan 2019

Two-Stage Bagging Pruning For Reducing The Ensemble Size And Improving The Classification Performance, Hua Zhang, Yujie Song, Bo Jiang, Bi Chen, Guogen Shan

Environmental & Global Health Faculty Research

Ensemble methods, such as the traditional bagging algorithm, can usually improve the performance of a single classifier. However, they usually require large storage space as well as relatively time-consuming predictions. Many approaches were developed to reduce the ensemble size and improve the classification performance by pruning the traditional bagging algorithms. In this article, we proposed a two-stage strategy to prune the traditional bagging algorithm by combining two simple approaches: accuracy-based pruning (AP) and distance-based pruning (DP). These two methods, as well as their two combinations, “AP+DP” and “DP+AP” as the two-stage pruning strategy, were all examined. Comparing with the single …


Maintaining Stability In A Changing Climate: A Comparative Analysis Of Public Health Systems And Migration Policies In The U.S. And Canada, Laura Cutlip Jan 2019

Maintaining Stability In A Changing Climate: A Comparative Analysis Of Public Health Systems And Migration Policies In The U.S. And Canada, Laura Cutlip

Climate and Society

This paper examines the relation between climate change, migration, and public health to better understand how the United States health system is positioned to deal with likely challenges to human health posed by environmental changes. The author reviews probable impacts of climate change on population displacement and disease before considering how the current structure of the health system of the United States will render it unable to adapt to these changes and challenges. The Canadian health care system and refugee policies are then reviewed to provide a counterpoint to this analysis. These findings are then considered in tandem as the …


Bioaerosol Concentrations And Size Distributions During The Autumn And Winter Seasons In An Industrial City Of Central China, Lung-Wen Chen, Ting Liu, Mi Zhang, John G. Watson, Judith C. Chow, Junji Cao, Hongyu Chen, Wei Wang, Jiaquan Zhang, Changlin Zhan, Hongxia Liu, Jingru Zheng, Naiwen Chen, Ruizhen Yao, Wensheng Xiao Jan 2019

Bioaerosol Concentrations And Size Distributions During The Autumn And Winter Seasons In An Industrial City Of Central China, Lung-Wen Chen, Ting Liu, Mi Zhang, John G. Watson, Judith C. Chow, Junji Cao, Hongyu Chen, Wei Wang, Jiaquan Zhang, Changlin Zhan, Hongxia Liu, Jingru Zheng, Naiwen Chen, Ruizhen Yao, Wensheng Xiao

Environmental & Global Health Faculty Research

The ambient bioaerosols were measured in PM2.5 and PM10 samples taken in Huangshi City, Hubei Province, China, during autumn and winter from November 2017 to February 2018. Both the bioaerosol number concentration and size distribution (0.37–16 µm) were obtained by direct fluorescent staining coupled with microscopic imaging. The bioaerosol number concentrations ranged from 0.05 to 3.4 # cm–3 for PM2.5 and from 0.17 to 5.7 # cm–3 for PM10, with averages of 0.90 # cm–3 and 1.9 # cm–3, respectively. In terms of particle number, the bioaerosols were dominated by fine particles (0.37–2.5 µm in diameter), with a larger proportion …


Mitsui-7,Heat-Treated, And Nitrogen-Doped Multi-Walled Carbon Nanotubes Elicit Genotoxicity In Human Lung Epithelial Cells, Katelyn J. Siegrist, Steven H. Reynolds, Dale W. Porter, Robert R. Mercer, Allison K. Bauer, David Lowry, Lorenzo Cena, Todd A. Stueckle, Michael L. Kashon, John Wiley, Jeffrey L. Salisbury, John Mastovich, Kristin Bunker, Mark Sparrow, Jason S. Lupoi, Aleksandr B. Stefaniak, Michael J. Keane, Shuji Tsuruoka, Mauricio Terrones, Michael Mccawley, Linda M. Sargent Jan 2019

Mitsui-7,Heat-Treated, And Nitrogen-Doped Multi-Walled Carbon Nanotubes Elicit Genotoxicity In Human Lung Epithelial Cells, Katelyn J. Siegrist, Steven H. Reynolds, Dale W. Porter, Robert R. Mercer, Allison K. Bauer, David Lowry, Lorenzo Cena, Todd A. Stueckle, Michael L. Kashon, John Wiley, Jeffrey L. Salisbury, John Mastovich, Kristin Bunker, Mark Sparrow, Jason S. Lupoi, Aleksandr B. Stefaniak, Michael J. Keane, Shuji Tsuruoka, Mauricio Terrones, Michael Mccawley, Linda M. Sargent

Faculty & Staff Scholarship

The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer designated the pristine Mitsui-7 MWCNT (MWCNT-7) as a Group 2B carcinogen, but there was insufficient data to classify all other MWCNT. Previously, MWCNT exposed to high temperature (MWCNT-HT) or synthesized with nitrogen (MWCNT-ND) have been found to elicit attenuated toxicity; however, their genotoxic and carcinogenic potential are not known. Our aim was to measure the genotoxicity of …


Multi-Walled Carbon Nanotube-Induced Gene Expression Biomarkers For Medical And Occupational Surveillance, Brandi N. Snyder-Talkington, Chunlin Dong, Salvi Singh, Rebecca Raese, Yong Qian, Dale W. Porter, Michael G. Wolfarth, Nancy L. Guo Jan 2019

Multi-Walled Carbon Nanotube-Induced Gene Expression Biomarkers For Medical And Occupational Surveillance, Brandi N. Snyder-Talkington, Chunlin Dong, Salvi Singh, Rebecca Raese, Yong Qian, Dale W. Porter, Michael G. Wolfarth, Nancy L. Guo

Faculty & Staff Scholarship

As the demand for multi-walled carbon nanotube (MWCNT) incorporation into industrial and biomedical applications increases, so does the potential for unintentional pulmonary MWCNT exposure, particularly among workers during manufacturing. Pulmonary exposure to MWCNTs raises the potential for development of lung inflammation, fibrosis, and cancer among those exposed; however, there are currently no effective biomarkers for detecting lung fibrosis or predicting the risk of lung cancer resulting from MWCNT exposure. To uncover potential mRNAs and miRNAs that could be used as markers of exposure, this study compared in vivo mRNA and miRNA expression in lung tissue and blood of mice exposed …