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Influence Of Prenatal Lead Exposure On Genomic Methylation Of Cord Blood Dna, Richard J. Pilsner, Howard Hu, Adrienne Ettinger, Brisa N. Sánchez, Robert O. Wright, David Cantonwine, Alicia Lazarus, Héctor Lamadrid-Figueroa, Adriana Mercado-García, Martha Maria Téllez-Rojo, Mauricio Hernández-Avila
Influence Of Prenatal Lead Exposure On Genomic Methylation Of Cord Blood Dna, Richard J. Pilsner, Howard Hu, Adrienne Ettinger, Brisa N. Sánchez, Robert O. Wright, David Cantonwine, Alicia Lazarus, Héctor Lamadrid-Figueroa, Adriana Mercado-García, Martha Maria Téllez-Rojo, Mauricio Hernández-Avila
J. Richard Pilsner
Background
Fetal lead exposure is associated with adverse pregnancy outcomes and developmental and cognitive deficits; however, the mechanism(s) by which lead-induced toxicity occurs remains unknown. Epigenetic fetal programming via DNA methylation may provide a pathway by which environmental lead exposure can influence disease susceptibility.
Objective
This study was designed to determine whether prenatal lead exposure is associated with alterations in genomic methylation of leukocyte DNA levels from umbilical cord samples.
Methods
We measured genomic DNA methylation, as assessed by Alu and LINE-1 (long interspersed nuclear element-1) methylation via pyrosequencing, on 103 umbilical cord blood samples from the biorepository of the …